The effect of Nigella sativa oil against experimental allergic encephalomyelitis via nitric oxide and other oxidative stress parameters

Cellular and Molecular Biology

Volumn 51, Issue 3, 2005, Pages 337-342

  Ozugurlu, F ^a   Sahin, S ^a   Idiz, N ^b   Akyol, O ^c   Ilhan, A ^d   Yigitoglu, R ^e   Isik, B ^f  

^a GAZIOSMANPASA UNIVERSITY   (Turkey)

^b ANKARA UNIVERSITY   (Turkey)

^c HACETTEPE UNIVERSITY   (Turkey)

^d INONU UNIVERSITY SCHOOL OF MEDICINE   (Turkey)

^e FATIH UNIVERSITY MEDICAL SCHOOL   (Turkey)

^f NONE   (Turkey)

Author keywords

Antioxidants; Experimental autoimmune encephalomyelitis; Multiple sclerosis; Nigella sativa; Nitric oxide; Oxidants

Indexed keywords

ANTIOXIDANT; FREUND ADJUVANT; MYELIN BASIC PROTEIN; NIGELLA SATIVA EXTRACT; OXIDIZING AGENT; REACTIVE OXYGEN METABOLITE; VEGETABLE OIL;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BLACK CUMIN; BRAIN; BRAIN LEVEL; CONTROLLED STUDY; DISEASE EXACERBATION; FEMALE; GUINEA PIG; HEAT; INFLAMMATION; INFLAMMATORY CELL; MULTIPLE SCLEROSIS; MYCOBACTERIUM TUBERCULOSIS; NERVOUS TISSUE; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; RAT; SPINAL CORD; TISSUE INJURY;

ANIMALS; ANTI-INFLAMMATORY AGENTS; BRAIN; BRAIN CHEMISTRY; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEMALE; FREUND'S ADJUVANT; GLUTATHIONE PEROXIDASE; MALONDIALDEHYDE; MYCOBACTERIUM TUBERCULOSIS; MYELIN BASIC PROTEINS; NITRIC OXIDE; OXIDATIVE STRESS; PLANT OILS; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; SUPEROXIDE DISMUTASE;

ANIMALIA; CAVIA PORCELLUS; MYCOBACTERIUM TUBERCULOSIS; NIGELLA SATIVA;

EID: 30744452481     PISSN: 01455680     EISSN: 1165158X     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Akyol, O., Zoroglu, S.S., Armutcu, F., Sahin, S. and Gurel, A., Nitric oxide as a physiopathological factor in neuropsychiatric disorders. In Vivo 2004, 18:377-390.
2. Al-Ghamdi, M.S., The anti-inflammatory, analgesic and antipyretic activity of Nigella sativa. J. Ethnopharmacol. 2001, 76: 45-48.
3. Beckman, J.S., Ischiropoulos, H., Zhu, L., vander Woerd, M., Smith, C., Chen, J., Harrison, J., Martin, J.C. and Tsai, M., Kinetics of superoxide dismutase- and iron catalysed nitration of phenolics by peroxynitrite. Arch. Biochem. Biophys. 1992, 298:438-445.
4. Burtis, M. and Bucar, F., Antioxidant activity of Nigella sativa essential oil. Phytother. Res. 2000, 14:323-328.
5. Cortas, N.K. and Wakid, N.W., Determination of inorganic nitrate in serum and urine by a kinetic cadmium-reduction method. Clin. Chem. 1990, 36:1440-1443.
6. El-Mahmoudy A., Matsuyama, H., Borgan, M.A., Shimizu, Y., El-Sayed, M.G., Minamoto, N. and Takewaki, T., Thymoquinone suppresses expression of inducible nitric oxide synthase in rat macrophages. Int. Immunopharmacol. 2002, 2: 1603-1611.
7. Esterbauer, H. and Cheeseman, K.H., Determination of aldehydic lipid peroxidation products: Malonaldehyde and 4-hydroxynonenal. In: Oxygen Radicals in Biological Systems, Methods in Enzymology, Packer, L. and Glazer, A.N. (eds.), Acad. Press, California 1990, 186: pp. 407-421.
8. Evans, P.H., Free radicals in brain metabolism and pathology. Br. Med. Bull. 1993, 49:577-587.
9. Giorelli, M., Livrea, P. and Trojano, M., Post-receptorial mechanisms underlie functional disregulation of β2-adrenergic receptors in lymphocytes from multiple sclerosis patients. J. Neuroimmunol. 2004, 155:143-149.
10. Greco, A., Minghetti, L., Puopolo, M., Cannoni, S., Romano, S., Pozzilli, C. and Levi, G., Cerebrospinal fluid isoprostanes are to related to inflammatory activity in relapsing-remitting multiple sclerosis. J. Neurol. Sci. 2004, 224: 23-27.
11. Ilhan, A., Akyol, O., Gurel, A., Armutcu, F., Iraz, M. and Oztas, E., Protective effects of caffeic acid phenethyl ester against experimental allergic encephalomyelitis-induced oxidative stress in rats. Free Radic. Biol. Med. 2004, 37: 386-394.
12. Lowry O., Rosenbraugh, N., Farr, L. and Rondall, R., Protein measurement with the Folin-phenol reagent. J. Biol. Chem. 1951, 183:265-275.
13. Martin, R., McFarland, H.F. and McFarlin, D.E., Immunological aspects of demyelinating diseases. Annu. Rev. Immunol. 1992, 10: 153-187.
14. Neumann, H., Medana, I.M., Bauer, J. and Lassmann, H., Cytotoxic T lymphocytes in autoimmune and degenerative CNS diseases. Trends Neurosci. 2002, 25: 313-319.
15. Ozgocmen, S., Sogut, S., Ardicoglu, O., Fadillioglu, E., Pekkutucu, I. and Akyol, O., Serum nitric oxide, catalase, superoxide dismutase, and malondialdehyde status in patients with ankylosing spondylitis. Rheumatol. Int. 2004; 24: 80-83.
16. Paglia, D.E. and Valentine, W.N., Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J. Lab. Clin. Med. 1967, 70: 158-170.
17. Prajda, N. and Weber, G., Malign transformation-linked imbalance: decreased XO activity in hepatomas. FEBS Lett. 1975, 59:245-249.
18. Salem, M.L. and Hossain, M.S., In vivo acute depletion of CD8(+) T cells before murine cytomegalovirus infection upregulated innate antiviral activity of natural killer cells. Int. J. Immunopharmacol. 2000, 22: 707-718.
19. Smith, K.J. and Lassmann, H., The role of nitric oxide in multiple sclerosis. Lancet Neurol. 2002, 1: 232-241.
20. Sun, Y., Oberley, L.W. and Li, Y., A simple method for clinical assay of superoxide dismutase. Clin. Chem. 1988, 34:497-500.
21. Winrow, V.R., Winyard, P.G., Morris, C.J. and Blake, D.R., Free radicals in inflammation: second messengers and mediators of tissue destruction. Br. Med. Bull. 1993, 49:506-522.