Stability of clozapine stored in oral suspension vehicles at room temperature

Canadian Journal of Hospital Pharmacy

Volumn 58, Issue 5, 2005, Pages 279-284

  Walker, Scott E ^a,b   Baker, Diane ^c   Law, Shirley ^a  

^a SUNNYBROOK RESEARCH INSTITUTE   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c CENTRE FOR ADDICTION AND MENTAL HEALTH   (Canada)

Author keywords

Clozapine; Commercial suspending agents; Drug stability; Suspensions

Indexed keywords

CLOZAPINE; DRUG VEHICLE;

ACCURACY; ARTICLE; CONCENTRATION (PARAMETERS); CONTAINER; CONTROLLED STUDY; DRUG DEGRADATION; DRUG FORMULATION; DRUG STABILITY; DRUG STORAGE; QUANTITATIVE ANALYSIS; RADIATION DETECTION; REPRODUCIBILITY; REVERSED PHASE LIQUID CHROMATOGRAPHY; ROOM TEMPERATURE; SUSPENSION; ULTRAVIOLET RADIATION; VALIDATION PROCESS;

EID: 30744450488     PISSN: 00084123     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (14)

1. Clozaril (Novartis Pharmaceuticals) [product monograph]. In: Repchinsky C, editor. Compendium of pharmaceuticals and specialities. Ottawa (ON): Canadian Pharmacists Association; 2003. p. 364-6.
2. Ramuth S, Flanagan RJ, Taylor DM. A liquid clozapine preparation for oral administration in hospital. Pharm J 1996;257:190-1.
3. Freiman JA, Chalmers TC, Smith H Jr, Kuebler RR. The importance of beta, the type II error and sample size in the design and interpretation of the randomized control trial. Survey of 71 "negative" trials. N Engl J Med 1978;299:690-4.
4. Stolley PD, Strom BL. Sample size calculations for clinical pharmacology studies. Clin Pharmacol Ther 1986;39:489-90.
5. Trissel LA. Avoiding common flaws in stability and compatibility studies of injectable drugs. Am J Hosp Pharm 1983;40:1159-60.
6. Trissel LA, Flora KP. Stability studies: five years later. Am J Hosp Pharm 1988;45:1569-71.
7. Policy for publication of chemical stability study manuscripts. Can J Hosp Pharm 1990;43:3-4.
8. When swallowing a tablet is a problem... a spoonful from Paddock helps the medicine go down [Internet]. Minneapolis (MN): Paddock Laboratories Inc; 2003. Available at: http://www.paddocklabs.com/ora.html. Accessed 2005 May 10.
9. SickKids® Pharmacy. Suspending vehicle HSC forumulation [Internet]. Toronto (ON): The Hospital for Sick Children; c 1999-2005. Available at: http://www.sickkids.ca/pharmacy/custom/suspending.asp. Accessed 2005 May 10.
10. Volpicelli SA, Centorrino F, Puopolo PR, Kando J, Frankenburg FR, Baldessarini RJ, et al. Determination of clozapine, norclozapine, and clozapine-N-oxide in serum by liquid chromatography. Clin Chem 1993;39:1656-9.
11. Weigmann H, Bierbrauer J, Hartter S, Hiemke C. Automated determination of clozapine and major metabolites in serum and urine. Ther Drug Monit 1997;19:480-8.
12. Weigmann H, Hiemke C. Determination of clozapine and its major metabolites in human serum using automated solid-phase extraction and subsequent isocratic high-performance liquid chromatography with ultraviolet detection. J Chromatogr 1992;583:209-16.
13. Hasan NY, Elkawy MA, Elzeany BE, Wagieh NE. Stability indicating methods for the determination of clozapine. J Pharm Biomed Anal 2002;30(1):35-47.
14. Shah VP, Midha KK, Dighe S, McGilveray IJ, Skelly JP, Yacobi A, et al. Analytical methods validation: bioavailability, bioequivalence and pharmacokinetic studies. Conference report. J Pharm Sci 1992;81:309-12.