Multiple functions of l0036 in the regulation of the pathogenicity island of enterohaemorrhagic Escherichia coli O157:H7

Biochemical Journal

Volumn 393, Issue 2, 2006, Pages 591-599

  Tsai, Nien Pei ^a   Wu, Yi Chih ^a   Chen, Jenn Wei ^a   Wu, Chih Feng ^a   Tzeng, Chi Meng ^b   Syu Jr , Wan ^a  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b U Vision Biotech Inc   (Taiwan)

Author keywords

Enterohaemorrhagic Escherichia coli (EHEC); Enteropathogenic Escherichia coli (EPEC); l0036; Pathogenesis; Regulation; Type III secretion

Indexed keywords

BIOLOGICAL ORGANS; BIOMECHANICS; EPITAXIAL GROWTH; GENES; PATHOLOGY; PROTEINS;

ENTEROHAEMORRHAGIC ESCHERICHIA COLI (EHEC); ENTEROPATHOGENIC ESCHERICHIA COLI (EPEC); PATHOGENESIS; TYPE III SECRETION;

ESCHERICHIA COLI;

ANIMAL CELL; ARTICLE; BACTERIAL INFECTION; BACTERIAL VIRULENCE; CITROBACTER RODENTIUM; DIARRHEA; EFFECTOR CELL; ENTEROHEMORRHAGIC ESCHERICHIA COLI; GENE LOCATION; GENETIC ORGANIZATION; INTESTINE BRUSH BORDER; INTESTINE EPITHELIUM; NONHUMAN; OPEN READING FRAME; PATHOGENICITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATOR GENE;

ESCHERICHIA COLI O157; ESCHERICHIA COLI PROTEINS; GENE EXPRESSION REGULATION, BACTERIAL; GENES, BACTERIAL; GENETIC COMPLEMENTATION TEST; GENOMIC ISLANDS; OPEN READING FRAMES; OPERON; VIRULENCE FACTORS;

ANIMALIA; BACTERIA (MICROORGANISMS); CITROBACTER RODENTIUM; ESCHERICHIA COLI; ESCHERICHIA COLI O157:H7;

EID: 30744450000     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20051201     Document Type: Article

References (27)

1. Frankel, G., Phillips, A. D., Rosenshine, I., Dougan, G., Kaper, J. B. and Knutton, S. (1998) Enteropathogenic and enterohaemorrhagic Escherichia coli: More subversive elements. Mol. Microbiol. 30, 911-921
2. McDaniel, T. K., Jarvis, K. G., Donnenberg, M. S. and Kaper, J. B. (1995) A genetic locus of enterocyte effacement conserved among diverse enterobacterial pathogens. Proc. Natl. Acad. Sci. U.S.A. 92, 1664-1668
3. Mellies, J. L., Elliott, S. J., Sperandio, V., Donnenberg, M. S. and Kaper, J. B. (1999) The Per regulon of enteropathogenic Escherichia coli: identification of a regulatory cascade and a novel transcriptional activator, the locus of enterocyte effacement (LEE)-encoded regulator (Ler). Mol. Microbiol. 33, 296-306
4. Sperandio, V., Mellies, J. L., Nguyen, W., Shin, S. and Kaper, J. B. (1999) Quorum sensing controls expression of the type III secretion gene transcription and protein secretion in enterohaemorrhagic and enteropathogenic Escherichia coli. Proc. Natl. Acad. Sci. U.S.A. 96, 15196-15201
5. Friedberg, D., Umanski, T., Fang, Y. and Rosenshine, I. (1999) Hierarchy in the expression of the locus of enterocyte effacement genes of enteropathogenic Escherichia coli. Mol. Microbiol. 34, 941-952
6. Bustamante, V. H., Santana, F. J., Calva, E. and Puente, J. L. (2001) Transcriptional regulation of type III secretion genes in enteropathogenic Escherichia coli: Ler antagonizes H-NS-dependent repression. Mol. Microbiol. 39, 664-678
7. Elliott, S. J., Sperandio, V., Giron, J. A., Shin, S., Mellies, J. L., Wainwright, L., Hutcheson, S. W., McDaniel, T. K. and Kaper, J. B. (2000) The locus of enterocyte effacement (LEE)-encoded regulator controls expression of both LEE- and non-LEE-encoded virulence factors in enteropathogenic and enterohaemorrhagic Escherichia coli. Infect. Immun. 68, 6115-6126
8. Sperandio, V., Mellies, J. L., Delahay, R. M., Frankel, G., Crawford, J. A., Nguyen, W. and Kaper, J. B. (2000) Activation of enteropathogenic Escherichia coli (EPEC) LEE2 and LEE3 operons by Ler. Mol. Microbiol. 38, 781-793
9. Haack, K. R., Robinson, C. L., Miller, K. J., Fowlkes, J. W. and Mellies, J. L. (2003) Interaction of Ler at the LEE5 (tir) operon of enteropathogenic Escherichia coli. Infect. Immun. 71, 384-392
10. Deng, W., Puente, J. L., Gruenheid, S., Li, Y., Vallance, B. A., Vazquez, A., Barba, J., Ibarra, J. A., O'Donnell, P., Metalnikov, P., Ashman, K. et al. (2004) Dissecting virulence: Systematic and functional analyses of a pathogenicity island. Proc. Natl. Acad. Sci. U.S.A. 101, 3597-3602
11. Lio, J. C.-W. and Syu, W.-J. (2004) Identification of a negative regulator for the pathogenicity island of enterohaemorrhagic Escherichia coli O157:H7. J. Biomed. Sci. 11, 855-863
12. Umanski, T., Rosenshine, I. and Friedberg, D. (2002) Thermoregulated expression of virulence genes in enteropathogenic Escherichia coli. Microbiology 148, 2735-2744
13. Aizawa, S. I. (2001) Bacterial flagella and type III secretion systems. FEMS Microbiol. Lett. 202, 157-164
14. Link, A. J., Phillips, D. and Church, G. M. (1997) Methods for generating precise deletions and insertions in the genome of wild-type Escherichia coli: application to open reading frame characterization. J. Bacteriol. 179, 6228-6237
15. Chiu, H. J., Lin, W. S. and Syu, W. J. (2003) Type III secretion of EspB in enterohaemorrhagic Escherichia coli O157:H7. Arch. Microbiol. 180, 218-226
16. Hsu, S. C., Lin, H. P., Wu, J. C., Ko, K. L., Sheen, I. J., Yan, B. S., Chou, C. K. and Syu, W. J. (2000) Characterization of a strain-specific monoclonal antibody to hepatitis delta virus antigen. J. Virol. Methods 87, 53-62
17. Yan, B. S., Lee, K. M., Liu, S. H. and Syu, W. J. (1996) Characterization of monoclonal antibodies to the 26-kDa glutathione S-transferase of Schistosoma japonicum. Hybridoma 15, 429-433
18. Chang, Y. Y., Yu, S. L. and Syu, W. J. (1999) Organization of HIV-1 Pol is critical for pol polyprotein processing. J. Biomed. Sci. 6, 333-341
19. Chuang, C. H., Hsu, S. C., Hsu, C. L., Hsu, T. C. and Syu, W. J. (2001) Construction of a tagging system for subcellular localization of proteins encoded by open reading frames. J. Biomed. Sci. 8, 170-175
20. Miller, J. H. (1972) Experiments in Molecular Genetics, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
21. Gauthier, A., Puente, J. L. and Finlay, B. B. (2003) Secretion of the enteropathogenic Escherichia coli type III secretion system requires components of the type III apparatus for assembly and localization. Infect. Immun. 71, 3310-3319
22. Jarvis, K. G., Giron, J. A., Jerse, A. E., McDaniel, T. K., Donnenberg, M. S. and Kaper, J. B. (1995) Enteropathogenic Escherichia coli contains a putative type III secretion system necessary for the export of proteins involved in attaching and effacing lesion formation. Proc. Natl. Acad. Sci. U.S.A. 92, 7996-8000
23. Elliott, S. J., Wainwright, L. A., McDaniel, T. K., Jarvis, K. G., Deng, Y. K., Lai, L. C., McNamara, B. P., Donnenberg, M. S. and Kaper, J. B. (1998) The complete sequence of the locus of enterocyte effacement (LEE) from enteropathogenic Escherichia coli e2348/69. Mol. Microbiol. 28, 1-4
24. Sukhan, A., Kubori, T. and Galan, J. E. (2003) Synthesis and localization of the Salmonella SPI-1 type III secretion needle complex proteins PrgI and PrgJ. J. Bacteriol. 185, 3480-3483
25. Kimbrough, T. G. and Miller, S. I. (2000) Contribution of Salmonella typhimurium type III secretion components to needle complex formation. Proc. Natl. Acad. Sci. U.S.A. 97, 11008-11013
26. Yu, X. J., Liu, M. and Holden, D. W. (2004) SsaM and SpiC interact and regulate secretion of Salmonella pathogenicity island 2 type III secretion system effectors and translocators. Mol. Microbiol. 54, 604-619
27. Pallen, M. J., Beatson, S. A. and Baile, C. M. (2005) Bioinformatics analysis of the locus for enterocyte effacement provides novel insights into type-III secretion. BMC Microbiol. 5, 9