Family history is a poor screen for prothrombotic genes in children with stroke

Journal of Pediatrics

Volumn 148, Issue 1, 2006, Pages 68-71

  Johal, Sheila C ^b   Garg, Bhuwan P ^b   Heiny, Mark E ^b   Williams, Linda S ^b   Saha, Chandan ^b   Walsh, Laurence E ^b   Golomb, Meredith R ^a  

^a INDIANA UNIVERSITY   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD CLOTTING FACTOR 5 LEIDEN; PROTHROMBIN;

ANAMNESIS; CEREBROVASCULAR ACCIDENT; CHILD; CONTROLLED STUDY; DEEP VEIN THROMBOSIS; DEMOGRAPHY; DISEASE ASSOCIATION; FEMALE; GENE MUTATION; GENETIC RISK; GENETIC SCREENING; HEART INFARCTION; HETEROZYGOSITY; HUMAN; MAJOR CLINICAL STUDY; MALE; PATHOLOGY; POPULATION RESEARCH; PRIORITY JOURNAL; RETROSPECTIVE STUDY; REVIEW; SPONTANEOUS ABORTION; STROKE; THROMBOSIS; VEIN THROMBOSIS;

EID: 30744449767     PISSN: 00223476     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpeds.2005.08.032     Document Type: Article

References (21)

1. U. Nowak-Gottl, R. Strater, A. Heinecke, R. Junker, H.G. Koch, and G. Schuierer Lipoprotein (a) and genetic polymorphisms of clotting Factor V, prothrombin, and methylenetetrahydrofolate reductase are risk factors of spontaneous ischemic stroke in childhood Blood 94 1999 3678 3682
2. W. Zenz, Z. Bodo, J. Plotho, W. Streif, C. Male, and G. Bernert Factor V Leiden and prothrombin gene G 20210 A variant in children with ischemic stroke Thrombosis & Haemostasis 80 1998 763 766
3. K.H. Reuner, A. Ruf, A. Grau, H. Rickmann, E. Stolz, and E. Juttler Prothrombin gene G20210->A transition is a risk factor for cerebral venous thrombosis Stroke 29 1998 1765 1769
4. U. Nowak-Gottl, R. Junker, W. Kreuz, A. von Eckardstein, A. Kosch, and N. Nohe Childhood Thrombophilia Study G. Risk of recurrent venous thrombosis in children with combined prothrombotic risk factors Blood 97 2001 858 862
5. U. Nowak-Gottl, C. Wermes, R. Junker, H.G. Koch, R. Schobess, and G. Fleischhack Prospective evaluation of the thrombotic risk in children with acute lymphoblastic leukemia carrying the MTHFR TT 677 genotype, the prothrombin G20210A variant, and further prothrombotic risk factors Blood 93 1999 1595 1599
6. V. De Stefano, I. Martinelli, P.M. Mannucci, K. Paciaroni, P. Chiusolo, and I. Casorelli The risk of recurrent deep venous thrombosis among heterozygous carriers of both Factor V Leiden and the G20210A prothrombin mutation N Engl J Med 341 1999 801 806
7. B. Cosmi, C. Legnani, F. Bernardi, S. Coccheri, and G. Palareti Value of family history in identifying women at risk of venous thromboembolism during oral contraception: observational study BMJ 322 2001 1024 1025
8. R.P. Lensen, R.M. Bertina, H. de Ronde, J.P. Vandenbroucke, and F.R. Rosendaal Venous thrombotic risk in family members of unselected individuals with Factor V Leiden Thromb Haemost 83 2000 817 821
9. N. Amberger, F. Masuhr, J.M. Valdueza, B. Vetter, and M. Weih A negative personal and family history for venous thrombotic events is not sufficient to exclude thrombophilia in patients with cerebral venous thrombosis Eur J Neurol 11 2004 555 558
10. C.M. Schambeck, S. Schwender, I. Haubitz, U.E. Geisen, R.E. Grossmann, and F. Keller Selective screening for the Factor V Leiden mutation: is it advisable prior to the prescription of oral contraceptives? Thromb Haemost 78 1997 1480 1483
11. J.N. Hagstrom, J. Walter, R. Bluebond-Langner, J.C. Amatniek, C.S. Manno, and K.A. High Prevalence of the Factor V Leiden mutation in children and neonates with thromboembolic disease J Pediatr 133 1998 777 781
12. G. deVeber, M. Andrew, and C.P.S.S. Group Cerebral sinovenous thrombosis in children New Engl J Med 345 2001 417 423
13. R. Strater, S. Becker, A. von Eckardstein, A. Heinecke, S. Gutsche, and R. Junker Prospective assessment of risk factors for recurrent stroke during childhood: a 5-year follow-up study Lancet 360 2002 1540 1545
14. K. Kurnik, A. Kosch, R. Strater, R. Schobess, C. Heller, and U. Nowak-Gottl Recurrent thromboembolism in infants and children suffering from symptomatic neonatal arterial stroke: a prospective follow-up study Stroke 34 2003 2887 2892
15. S. Lanthier, L. Carmant, M. David, A. Larbrisseau, and G. de Veber Stroke in children: the coexistence of multiple risk factors predicts poor outcome Neurology 54 2000 371 378
16. R. Lensen, F. Rosendaal, J. Vandenbroucke, and R. Bertina Factor V Leiden: the venous thrombotic risk in thrombophilic families Br J Haematol 110 2000 939 945
17. L.M. Reich, M. Bower, and N.S. Key Role of the geneticist in testing and counseling for inherited thrombophilia Genet Med 5 2003 133 143
18. V. Ganesan, M.A. McShane, R. Liesner, J. Cookson, I. Hann, and F.J. Kirkham Inherited prothrombotic states and ischaemic stroke in childhood J Neurol Neurosurg Psychiatry 65 1998 508 511
19. I. Aschka, V. Aumann, F. Bergmann, U. Budde, W. Eberl, and S. Eckhof-Donovan Prevalence of Factor V Leiden in children with thrombo-embolism Eur J Pediatr 155 1996 1009 1014
20. C. Barnes, F. Newall, J. Furmedge, M. Mackay, and P. Monagle Arterial ischaemic stroke in children J Paediatr Child Health 40 2004 384 387
21. M. Giroud, M. Lemesle, J.B. Gouyon, J.L. Nivelon, C. Milan, and R. Dumas Cerebrovascular disease in children under 16 years of age in the city of Dijon, France: a study of incidence and clinical features from 1985 to 1993 J Clin Epidemiol 48 1995 1343 1348