The use of citric acid to prolong the in vivo gastro-retention of a floating dosage form in the fasted state

International Journal of Pharmaceutics

Volumn 308, Issue 1-2, 2006, Pages 8-13

  Stops, Frances ^a   Fell, John T ^a   Collett, John H ^a   Martini, Luigi G ^b   Sharma, Harbans L ^a   Smith, Anne Marie ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Alginate; Beads; Citric acid; Floating dosage forms; Gastric retention; Scintigraphy

Indexed keywords

CALCIUM ALGINATE; CITRIC ACID; TECHNETIUM 99M; WATER;

ADULT; ARTICLE; DIET RESTRICTION; DRUG DOSAGE FORM; DRUG MECHANISM; GAMMA SCINTIGRAPHY; HUMAN; INTESTINE; ISOTOPE LABELING; MALE; NORMAL HUMAN; PRIORITY JOURNAL; STOMACH; STOMACH CONTENT; STOMACH EMPTYING;

ADULT; ALGINATES; CITRIC ACID; DELAYED-ACTION PREPARATIONS; DRUG CARRIERS; FASTING; GASTRIC EMPTYING; GASTROINTESTINAL TRACT; GASTROINTESTINAL TRANSIT; GLUCURONIC ACID; HEXURONIC ACIDS; HUMANS; HYDROGEN-ION CONCENTRATION; MALE; MIDDLE AGED; RADIOPHARMACEUTICALS; SODIUM PERTECHNETATE TC 99M; SOLUBILITY; SURFACE PROPERTIES;

EID: 30744435603     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2005.09.036     Document Type: Article

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