Quantitative serum free light chain assay in the diagnostic evaluation of AL amyloidosis

Amyloid

Volumn 12, Issue 4, 2005, Pages 210-215

  Akar, Harun ^a   Seldin, David C ^a   Magnani, Barbarajean ^a   O'Hara, Carl ^a   Berk, John L ^a   Schoonmaker, Christopher ^b   Cabral, Howard ^b   Dember, Laura M ^a   Sanchorawala, Vaishali ^a   Connors, Lawreen H ^a   Falk, Rodney H ^a   Skinner, Martha ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BOSTON UNIVERSITY SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

FLC; FLC; AL amyloidosis; Free light chains

Indexed keywords

IMMUNOGLOBULIN LIGHT CHAIN;

ADULT; AGED; AMYLOIDOSIS; ARTICLE; BLOOD EXAMINATION; BLOOD SALVAGE; CLINICAL ARTICLE; CLONAL VARIATION; CONTROLLED STUDY; DIAGNOSTIC APPROACH ROUTE; DIAGNOSTIC TEST; ELECTROIMMUNOASSAY; FALSE POSITIVE RESULT; FEMALE; HISTOPATHOLOGY; HUMAN; IMMUNOELECTROPHORESIS; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOHISTOCHEMISTRY; MALE; PRIORITY JOURNAL; RELIABILITY; TISSUE SECTION;

ADULT; AGED; AMYLOIDOSIS; HUMANS; IMMUNOASSAY; IMMUNOGLOBULIN KAPPA-CHAINS; IMMUNOGLOBULIN LAMBDA-CHAINS; MALE; MIDDLE AGED; NEPHELOMETRY AND TURBIDIMETRY; SENSITIVITY AND SPECIFICITY;

EID: 30744432108     PISSN: 13506129     EISSN: 17442818     Source Type: Journal    
DOI: 10.1080/13506120500352339     Document Type: Article

References (15)

1. Glenner GG, Terry W, Harada M, Isersky C, Page D. Amyloid fibril proteins: proof of homology with immunoglobulin light chains by sequence analyses. Science 1971;172:1150-1151.
2. Falk RH, Comenzo RL, Skinner M. The systemic amyloidoses. New Engl J Med 1997;337:898-909.
3. Kyle RA, Gertz MA. Primary systemic amyloidosis: clinical and laboratory features in 474 cases. Seminars in Hem 1995;32:45-59.
4. Sanchorawala V, Wright DG, Seldin DC, Dember L, Finn K, Falk RH, Berk J, Quillen K, Skinner M. An overview of the use of high-dose mephalan with autologous stem cell transplantation for the treatment of AL amyloidosis. Bone Marrow Transplant 2001;28:637-642.
5. Skinner M, Sanchorawala V, Seldin DC, Dember L, Falk RH, Berk J, Anderson JJ, O'Hara C, Finn K, Libbey CA, et al. Survival and clinical response to treatment with high-dose melphalan and autologous stem-cell transplantation in patients with AL amyloidosis: an 8-year study. Ann Intern Med 2004;140:85-93.
6. Seldin DC, Anderson JJ, Sanchorawala V, Malek K, Wright DG, Quillen K, Finn KT, Jerk JL, Dember LM, et al. Improvement in quality of life of patients with AL amyloidosis treated with high-dose melphalan and autologous stem cell transplantation. Blood 2004;104:1888-1893.
7. Dispenzieri A, Kyle RA, Lacy MQ, Therneau TM, Larson DR, Plevak MF, Rajkumar SV, Fonseca R, Greipp PR, Witzig TE, et al. Superior survival in primary systemic amyloidosis patients undergoing peripheral blood stem cell transplant: a case control study. Blood 2004;103:3960-3963.
8. Drayson M, Tang LX, Drew R, Mead GP, Carr-Smith HD, Bradwell AR. Serum free light chain measurements for identifying and monitoring patients with nonsecretory myeloma. Blood 2001;97:2900-2902.
9. Bradwell AR, Carr-Smith HD, Mead GP, Tang LX, Showell PJ, Drayson MT, Drew R. Highly sensitive, automated immunoasay for immunoglobulin free light chains in serum and urine. Clin Chem 2001;47:673-680.
10. Katzmann JA, Clark RJ, Abraham RS, Bryant S, Lymp JF, Bradwell AR, Kyle RA. Serum reference intervals and diagnostic ranges for free kappa and lambda immunoglobulin light chains: relative sensitivity for detection of monoclonal light chains. Clin Chem 2002;48:1437-1444.
11. Abraham RS, Clark RJ, Bryant SC, Lymp JF, Larson T, Kyle RA, Katzmann JA. Correlation of serum immunoglobulin free light chain quantification with urinary Bence Jones protein in light chain myeloma. Clin Chem 2002;48:655-657.
12. Swan N, Skinner M, O'Hara CJ. Bone marrow core biopsy specimens in AL(primary) amyloidosis. A morphologic and immunohistochemical study of 100 cases. Am J Clin Pathol 2003;120:610-616.
13. Bradwell AR. Serum free light chain analysis. 2nd ed. San Diego: The Binding Site Inc; 2004. pp 97-106.
14. Abraham RS, Katzmann JA, Clark RJ, Bradwell AR, Kyle RA, Gertz MA. Quantitative analysis of serum free light chains: a new marker for the diagnostic evaluation of primary systemic amyloidosis. Am J Clin Pathol 2003;119:274-278.
15. Lachmann HJ, Gallimore R, Gillmore JD, Carr-Smith HD, Bradwell AR, Pepys MB, Hawkins PN. Outcome in systemic AL amyloidosis in relation to changes in concentration of circulating free immunoglobulin light chains following chemotherapy. Br J Haematol 2003;122:78-84.