Mechanism of signal amplification in the olfactory sensory cilia

Journal of Neuroscience

Volumn 25, Issue 48, 2005, Pages 11084-11091

  Takeuchi, Hiroko ^a   Kurahashi, Takashi ^a  

^a OSAKA UNIVERSITY   (Japan)

Author keywords

Adenylyl cyclase; cAMP; Ion channel; Olfaction; Rod; Signal transduction

Indexed keywords

ADENOSINE TRIPHOSPHATE; CALCIUM; CYCLIC AMP; CYCLIC GMP; ENZYME;

ANIMAL CELL; ARTICLE; BIOLOGICAL MONITORING; BIOSYNTHESIS; CELL ACTIVITY; CONTROLLED STUDY; HYDROLYSIS; MOLECULAR BIOLOGY; MOLECULAR INTERACTION; MOLECULE; NEWT; NONHUMAN; ODOR; OLFACTORY RECEPTOR; OLFACTORY SYSTEM; PHOTON; PHOTORECEPTOR CELL; PRIORITY JOURNAL; SENSORY STIMULATION; SENSORY SYSTEM; SIGNAL TRANSDUCTION; SMELLING; THERMODYNAMICS;

ADENYLATE CYCLASE; ANIMALS; CELL MEMBRANE; CILIA; CYCLIC AMP; CYTOPLASM; ELECTRIC CONDUCTIVITY; INTRACELLULAR MEMBRANES; ION CHANNELS; LIGANDS; MODELS, NEUROLOGICAL; ODORS; OSMOLAR CONCENTRATION; RECEPTORS, SENSORY; SALAMANDRIDAE; SIGNAL TRANSDUCTION; ULTRAVIOLET RAYS;

EID: 30644478224     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.1931-05.2005     Document Type: Article

References (44)

1. Anholt RRH, Rivers AM (1990) Olfactory transduction: cross-talk between second-messenger systems. Biochemistry 29:4049-4054.
2. Araneda RC, Kini AD, Firestein S (2000) The molecular receptive range of an odorant receptor. Nat Neurosci 12:1248 -1255.
3. Bakalyar HA, Reed RR (1990) Identification of a specialized adenylyl cyclase that may mediate odorant detection. Science 250:1403-1406.
4. Balasubramanian S, Lynch JW, Barry PH (1996) Calcium-dependent modulation of the agonist affinity of the mammalian olfactory cyclic nucleotide-gated channel by calmodulin and a novel endogenous factor. J Memb 152:13-23.
5. Boekhoff H, Breer I (1992) Second messenger signaling in olfaction. Curr Opin Neurobiol 2:439-443.
6. Borisy FF, Ronett GV, Cunningham AM, Juilfs D, Beavo J, Snyder SH (1992) Calcium/calmodulin-activated phosphodiesterase expressed in olfactory receptor neurons. J Neurosci 12:915-923.
7. Bradley J, Reuter D, Frings S (2001) Facilitation of calmodulin-mediated odor adaptation by cAMP-gated channel subunits. Science 294:2176-2178.
8. Breer H, Boekhoff I, Tareilus E (1990) Rapid kinetics of second messenger formation in olfactory transduction. Nature 345:65-68.
9. Buck L, Axel R (1991) A novel multigene family may encode odorant receptors: a molecular basis for odor recognition. Cell 65:175-187.
10. 2+-calmodulin of cyclic nucleotide-activated channel of rat olfactory receptor neurons. Nature 368:545-548.
11. Firestein S, Shepherd GM, Werblin FS (1990) Time course of the membrane current underlying sensory transduction in salamander olfactory receptor neurons. J Physiol (Lond) 430:135-158.
12. Hamill OP, Marty A, Neher E, Sakmann B, Sigworth FJ (1981) Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Plfügers Arch 391:85-100.
13. Ito Y, Kurahashi T, Kaneko A (1995) Pressure control instrumentation for drug stimulation. Nippon Seirigaku Zasshi 57:127-133.
14. Jones DT, Reed RR (1989) Golf: an olfactory neuron specific-G protein involved in odorant signal transduction. Science 244:790-795.
15. Kleene SJ (1997) High-gain, low-noise amplification in olfactory transduction. Biophys J 73:1110-1117.
16. Kleene SJ, Gesteland RC (1991) Calcium-activated chloride conductance in frog olfactory cilia. J Neurosci 11:3624 -3629.
17. Kurahashi T (1989) Activation by odorants of cation-selective conductance in the olfactory receptor cell isolated from the newt. J Physiol (Lond) 419:177-192.
18. Kurahashi T (1990) The response induced by intracellular cyclic AMP in isolated olfactory receptor cells of the newt. J Physiol (Lond) 430:355-371.
19. Kurahashi T, Kaneko A (1991) High density cAMP-gated channels at the ciliary membrane in the olfactory receptor cell. NeuroReport 2:5-8.
20. Kurahashi T, Kaneko A (1993) Gating properties of the cAMP-gated channel in toad olfactory receptor cells. J Physiol (Lond) 466:287-302.
21. Kurahashi T, Menini A (1997) Mechanism of odorant adaptation in the olfactory receptor cell. Nature 385:725-729.
22. 2+-dependent adaptive properties in the solitary olfactory receptor cell of the newt. Brain Res 515:261-268.
23. Kurahashi T, Yau KW (1993) Co-existence of cationic and chloride components in odorant-induced current of vertebrate olfactory receptor cells. Nature 363:71-74.
24. Kurahashi T, Yau KW (1994) Olfactory transduction. Tale of an unusual chloride current. Curr Biol 4:256-258.
25. Lamb TD, Pugh Jr EN (1992) A quantitative account of the activation steps involved in phototransduction in amphibian photoreceptors. J Physiol (Lond) 449:719 -758.
26. Lowe G, Gold GH (1991) The spatial distributions of odorant sensitivity and odorant-induced currents in salamander olfactory receptor cells. J Physiol (Lond) 442:147-168.
27. Lowe G, Gold GH (1993a) Contribution of the ciliary cyclic nucleotidegated conductance to olfactory transduction in the salamander. J Physiol (Lond) 462:175-196.
28. Lowe G, Gold GH (1993b) Nonlinear amplification by calcium-dependent chloride channels in olfactory receptor cells. Nature 366:283-286.
29. Lowe G, Nakamura T, Gold GH (1989) Adenylate cyclase mediates olfactory transduction for a wide variety of odorants. Proc Natl Acad Sci USA 86:5641-5645.
30. Matthews HR, Reisert J (2003) Calcium, the two-faced messenger of olfactory transduction and adaptation. Curr Opin Neurobiol 13:469-475.
31. Menco BP (1980) Qualitative and quantitative freeze-fracture studies on olfactory and nasal respiratory structures of frog, ox, rat, and dog. I. A general survey. Cell Tissue Res 207:183-209.
32. Nakamura T, Gold GH (1987) A cyclic nucleotide-gated conductance in olfactory receptor cilia. Nature 325:442- 444.
33. Pace U, Hanski E, Salomon Y, Lancet D (1985) Odorant-sensitive adenylate cyclase may mediate olfactory reception. Nature 316:225-258.
34. Pugh Jr EN, Lamb TD (1990) Cyclic GMP and calcium: the internal messengers of excitation and adaptation in vertebrate photoreceptors. Vision Res 30:1923-1948.
35. Pugh Jr EN, Nikonov S, Lamb TD (1999) Molecular mechanisms of vertebrate photoreceptor light adaptation. Curr Opin Neurobiol 4:410-418.
36. Reisert J, Bauer PJ, Yau KW, Frings S (2003) The Ca-activated Cl channel and its control in rat olfactory receptor neurons. J Gen Physiol 122:349-363.
37. Restrepo D, Boekhoff I, Breer H (1993) Rapid kinetic measurements of second messenger formation in olfactory cilia from channel catfish. Am J Physiol 264:906-911.
38. Shapiro MS, Zagotta WN (2000) Structural basis for ligand selectivity of heteromeric olfactory cyclic nucleotide-gated channels. Biophys J 78:2307-2320.
39. Sklar PB, Anholt RRH, Snyder SH (1986) The odorant-sensitive adenylate cyclase of olfactory receptor cells. Differential stimulation by distinct classes of odorants. J Biol Chem 261:15538-15543.
40. Stryer L (1986) Cyclic GMP cascade of vision. Annu Rev Neurosci 9:87-119.
41. Takeuchi H, Kurahashi T (2002) Photolysis of caged cyclic AMP in the ciliary cytoplasm of the newt olfactory receptor cell. J Physiol (Lond) 541:825-833.
42. Takeuchi H, Kurahashi T (2003) Identification of second messenger mediating signal transduction in the olfactory receptor cell. J Gen Physiol 122:557-567.
43. Takeuchi H, Imanaka Y, Hirono J, Kurahashi T (2003) Cross-adaptation between olfactory responses induced by two subgroups of odorant molecules. J Gen Physiol 122:255-264.
44. Zufall F, Shepherd GM, Firestein S (1991) Inhibition of the olfactory cyclic nucleotide gated ion channel by intracellular calcium. Proc R Soc Lond B Biol Sci 246:225-230.