Cardiac fibrinolytic capacity is markedly increased after brief periods of local myocardial ischemia, but declines following successive periods in anesthetized pigs

Journal of Thrombosis and Haemostasis

Volumn 3, Issue 9, 2005, Pages 1947-1954

  Aspelin, Trude ^a   Eriksen, M ^b   Lindgaard, A K ^a   Lyberg, T ^a   Ilebekk, A ^b  

^a ULLEVÅL UNIVERSITY HOSPITAL   (Norway)

^b UNIVERSITY OF OSLO   (Norway)

Author keywords

Myocardial ischemia; PAI 1; Pig; Repeated periods of ischemia; tPA

Indexed keywords

PLASMINOGEN ACTIVATOR INHIBITOR 1; TISSUE PLASMINOGEN ACTIVATOR;

ANESTHESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; FIBRINOLYSIS; HEART FUNCTION; HEART MUSCLE ISCHEMIA; LEFT ANTERIOR DESCENDING CORONARY ARTERY; NONHUMAN; OCCLUSION; PRIORITY JOURNAL; VENOUS BLOOD;

ANGINA PECTORIS; ANIMALS; CORONARY CIRCULATION; CORONARY VESSELS; FEMALE; FIBRINOLYSIS; MALE; MODELS, ANIMAL; MYOCARDIAL ISCHEMIA; MYOCARDIAL REPERFUSION INJURY; PLASMINOGEN ACTIVATOR INHIBITOR 1; RECURRENCE; SWINE; TISSUE PLASMINOGEN ACTIVATOR;

EID: 30644471557     PISSN: 15387933     EISSN: 15387836     Source Type: Journal    
DOI: 10.1111/j.1538-7836.2005.01514.x     Document Type: Article

References (31)

1. Levin EG, del Zoppo GJ. Localization of tissue plasminogen activator in the endothelium of a limited number of vessels. Am J Pathol 1994; 144: 855-61.
2. Eijnden-Schrauwen Y, Kooistra T, de Vries RE, Emeis JJ. Studies on the acute release of tissue-type plasminogen activator from human endothelial cells in vitro and in rats in vivo: evidence for a dynamic storage pool. Blood 1995; 85: 3510-7.
3. Parmer RJ, Mahata M, Mahata S, Sebald MT, O'Connor DT, Miles LA. Tissue plasminogen activator (t-PA) is targeted to the regulated secretory pathway. Catecholamine storage vesicles as a reservoir for the rapid release of t-PA. J Biol Chem 1997; 272: 1976-82.
4. Wang Y, Jiang X, Hand AR, Gilles C, Kirk J, Cone RE, O'Rourke J. Additional evidence that the sympathetic nervous system regulates the vessel wall release of tissue plasminogen activator. Blood Coagul Fibrinolysis 2002; 13: 471-81.
5. Jiang X, Wang Y, Hand AR, Gillies C, Cone RE, Kirk J, O'Rourke J. Storage and release of tissue plasminogen activator by sympathetic axons in resistance vessel walls. Microvasc Res 2002; 64: 438-47.
6. Munkvad S, Gram J, Jespersen J. A depression of active tissue plasminogen activator in plasma characterizes patients with unstable angina pectoris who develop myocardial infarction. Eur Heart J 1990; 11: 525-8.
7. Held C, Hjemdahl P, Rehnqvist N, Wallen NH, Bjorkander I, Eriksson SV, Forslund L, Wiman B. Fibrinolytic variables and cardiovascular prognosis in patients with stable angina pectoris treated with verapamil or metoprolol. Results from the Angina Prognosis study in Stockholm. Circulation 1997; 95: 2380-6.
8. Winnerkvist A, Wiman B, Valen G, Vaage J. Release of tissue plasminogen activator during reperfusion after different times of ischaemia in isolated, perfused rat hearts. Thromb Res 1996; 82: 533-42.
9. Österlund B, Andersson B, Haggmark S, Jern C, Johansson G, Seeman-Lodding H, Biber B. Myocardial ischemia induces coronary t-PA release in the pig. Acta Anaesthesiol Scand 2002; 46: 271-8.
10. Jern C, Seeman-Lodding H, Biber B, Winso O, Jern S. An experimental multiple-organ model for the study of regional net release/uptake rates of tissue-type plasminogen activator in the intact pig. Thromb Haemost 1997; 78: 1150-6.
11. Björkman JA. Jern S, Jern C. Cardiac sympathetic nerve stimulation triggers coronary t-PA release. Arterioscler Thromb Vasc Biol 2003; 23: 1091-7.
12. Österlund B, Holmgren A, Haggmark S, Jern C, Johansson G, Seeman-Lodding H, Biber B. Surgical stress induces acute coronary release of tissue-type plasminogen activator in the pig. Acta Anaesthesiol Scand 2000; 44: 1226-31.
13. van Hinsbergh VW. The endothelium: vascular control of haemostasis. Eur J Obstet Gynecol Reprod Biol 2001; 95: 198-201.
14. Österlund B, Jern C, Seeman-Lodding H, Johansson G, Haggmark S, Broome M, Biber B. Intracoronary beta2 receptor activation induces dynamic local t-PA release in the pig. Thromb Haemost 2003; 90: 796-802.
15. Hoffmeister HM, Jur M, Ruf-Lehmann M, Helber U, Heller W, Seipel L. Endothelial tissue-type plasminogen activator release in coronary heart disease: transient reduction in endothelial fibrinolytic reserve in patients with unstable angina pectoris or acute myocardial infarction. J Am Coll Cardiol 1998; 31: 547-51.
16. Pich S, Klein HH, Lindert S, Nebendahl K, Kreuzer H. Cell death in ischemic, reperfused porcine hearts: a histochemical and functional study. Basic Res Cardiol 1988; 83: 550-9.
17. Horneffer PJ, Healy B, Gott VL, Gardner TJ. The rapid evolution of a myocardial infarction in an end-artery coronary preparation. Circulation 1987: 76: V39-42.
18. Grund F, Sommerschild HT, Kirkeboen KA, Ilebekk A. Preconditioning with ischaemia reduces both myocardial oxygen consumption and infarct size in a graded pattern. J Mol Cell Cardiol 1997; 29: 3067-79.
19. Gordon JL. Extracellular ATP: effects, sources and fate. Biochem J 1986; 233: 309-19.
20. Coade SB, Pearson JD. Metabolism of adenine nucleotides in human blood. Circ Res 1989; 65: 531-7.
21. Hrafnkelsdottir T, Erlinge D, Jern S. Extracellular nucleotides ATP and UTP induce a marked acute release of tissue-type plasminogen activator in vivo in man. Thromb Haemost 2001; 85: 875-81.
22. Kurz T, Richardt G, Hagl S, Seyfarth M, Schomig A. Two different mechanisms of noradrenaline release during normoxia and simulated ischemia in human cardiac tissue. J Mol Cell Cardiol 1995; 27: 1161-72.
23. Dell'Omo G, De Negri F, Carmassi F, Ruocco L, Mariani M, Pedrinelli R. Reactive hyperemia and tissue-type plasminogen activator release in hypertensive men. Blood Coagul Fibrinolysis 2003; 14: 19-25.
24. Sjogren LS, Gan L, Doroudi R, Jern C, Jungersten L, Jern S. Fluid shear stress increases the intra-cellular storage pool of tissue-type plasminogen activator in intact human conduit vessels. Thromb Haemost 2000; 84: 291-8.
25. Kawai Y, Matsumoto Y, Watanabe K, Yamamoto H, Satoh K, Murata M, Handa M, Ikeda Y. Hemodynamic forces modulate the effects of cytokines on fibrinolytic activity of endothelial cells. Blood 1996; 87: 2314-21.
26. O'Rourke J, Jiang X, Hao Z, Cone RE, Hand AR. Distribution of sympathetic tissue plasminogen activator (tPA) to a distant microvasculature. J Neurosci Res 2005; 79: 727-33.
27. Jiang X, Wang Y, Hand AR. Gillies C, Cone RE, O'Rourke J. Presence of tissue plasminogen activator (tPA) in the adventitial sympathetic nerves that innervate small arteries: morphologic evidence for a neural fibrinolysis. Fibrinolysis & Proteolysis 2000; 14: 35-46.
28. Matsumoto T, Minai K, Horie H, Ohira N, Takashima H, Tarutani Y, Yasuda Y, Ozawa T, Matsuo S, Kinoshita M, Horie M. Angiotensin-converting enzyme inhibition but not angiotensin II type 1 receptor antagonism augments coronary release of tissue plasminogen activator in hypertensive patients. J Am Coll Cardiol 2003; 41: 1373-9.
29. Loskutoff DJ. Regulation of PAI-1 gene expression. Fibrinolysis 1991; 5: 197-206.
30. Chmielewska J, Ranby M, Wiman B. Kinetics of the inhibition of plasminogen activators by the plasminogen-activator inhibitor. Evidence for 'second-site' interactions. Biochem J 1988; 251: 327-32.
31. Hrafnkelsdottir T, Gudnason T, Wall U, Jern C, Jem S. Regulation of local availability of active tissue-type plasminogen activator in vivo in man. J Thromb Haemost 2004; 2: 1960-8.