Restricted κ/λ light chain ratio by flow cytometry in germinal center B cells in Hashimoto thyroiditis

American Journal of Clinical Pathology

Volumn 125, Issue 1, 2006, Pages 42-48

  Chen, Henry I ^a   Akpolat, Ikser ^a   Mody, Dina R ^a,b   Lopez Terrada, Dolores ^a   De Leon, Audrey Ponce ^a   Luo, Yamin ^a   Jorgensen, Jeffrey ^a,d   Schwartz, Mary R ^a   Chang, Chung Che ^a,b,c  

^a Department of Obstetrics Gynecology   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

^c HOUSTON METHODIST HOSPITAL   (United States)

^d UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

Flow cytometry; Hashimoto thyroiditis; Light chain restricted B cells

Indexed keywords

COMMON ACUTE LYMPHOBLASTIC LEUKEMIA ANTIGEN; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN KAPPA CHAIN; IMMUNOGLOBULIN LAMBDA CHAIN; PROTEIN BCL 2;

ADULT; ARTICLE; ASPIRATION BIOPSY; B LYMPHOCYTE; CLINICAL ARTICLE; CLONAL VARIATION; DIAGNOSTIC VALUE; DNA EXTRACTION; FEMALE; FLOW CYTOMETRY; FLUORESCENCE ACTIVATED CELL SORTING; FOLLOW UP; FUSION GENE; GENE REARRANGEMENT; GERMINAL CENTER; HASHIMOTO DISEASE; HUMAN; HUMAN TISSUE; IMMUNOPHENOTYPING; LYMPHOMA; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; STATISTICAL ANALYSIS;

EID: 30644469112     PISSN: 00029173     EISSN: None     Source Type: Journal    
DOI: 10.1309/1G5F902YE7DDUNMA     Document Type: Article

References (26)

1. Hashimoto H. Zur Kenntniss der lymphomatosen veranderung der schilddruse (struma lymphomatosa). Arch Klin Chir. 1912;97:219-248.
2. Rosai J, ed. Ackerman's Surgical Pathology. Vol 1. 8th ed. St Louis, MO: Mosby-Year Book; 1996.
3. Thieblemont C, Mayer A, Dumontet C, et al. Primary thyroid lymphoma is a heterogeneous disease. J Clin Endocrinol Metab. 2002;87:105-111.
4. Sangalli G, Serio G, Zampatti C, et al. Fine needle aspiration cytology of primary lymphoma of the thyroid: a report of 17 cases. Cytopathology. 2001;12:257-263.
5. Hsi ED, Singleton TP, Svoboda SM, et al. Characterization of the lymphoid infiltrate in Hashimoto thyroiditis by immunohistochemistry and polymerase chain reaction for immunoglobulin heavy chain gene rearrangement. Am J Clin Pathol. 1998;110:327-333.
6. Reichard KK, McKenna RW, Kroft SH. Comparative analysis of light chain expression in germinal center cells and mantle cells of reactive lymphoid tissues. Am J Clin Pathol. 2003;119:130-136.
7. Kussick SJ, Kalnoski M, Braziel RM, et al. Prominent clonal B-cell populations identified by flow cytometry in histologically reactive lymphoid proliferations. Am J Clin Pathol. 2004;121:464-472.
8. Chang C, Cleveland R. Decreased CD10+ mature granulocytes in bone marrow from patients with myelodysplastic syndrome. Arch Pathol Lab Med. 2000;124:1152-1156.
9. Chang C, Schur BC, Kampalath B, et al. A novel multiparametric approach for analysis of cytoplasmic immunoglobulin light chains by flow cytometry. Mod Pathol. 2001;14:1015-1021.
10. Novoa-Takara L, Perkins SL, Qi D, et al. Histogenetic phenotypes of B cells in posttransplant lymphoproliferative disorders by immunohistochemical analysis correlate with transplant type: solid organ vs hematopoietic stem cell transplantation. Am J Clin Pathol. 2005;123:104-112.
11. Chang C, Bredeson C, Juckett M, et al. Tumor load in patients with follicular lymphoma post stem cell transplantation may correlate with clinical course. Bone Marrow Transplant. 2003;32:287-291.
12. McGregor D, Keever-Taylor CA, Bredeson C, et al. The implication of follicular lymphoma patients receiving allogeneic stem cell transplantation from donors carrying t(14;18) positive cells. Bone Marrow Transplant. 2005;35:1049-1054.
13. Geary WA, Frierson HF, Innes DJ, et al. Quantitative criteria for clonality in the diagnosis of B-cell non-Hodgkin's lymphoma by flow cytometry. Mod Pathol. 1993;6:155-161.
14. Taylor CR. Results of multiparameter studies of B-cell lymphomas. Am J Clin Pathol. 1979;72:687-698.
15. Kaleem Z, Vollmer RT, White G. Clonality evaluation in B-cell lymphoproliferative disorders by flow cytometric immunophenotyping [abstract]. Mod Pathol. 2001;14:152A.
16. Knowles DM. Immunophenotypic markers useful in the diagnosis and classification of hematopoietic neoplasms. In: Knowles DM, ed. Neoplastic Hematopathology. 2nd ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2001:185.
17. Matsubayashi S, Tamai H, Morita T, et al. Hashimoto's thyroiditis manifesting as monoclonal lymphocytic infiltration. Clin Exp Immunol. 1990;79:170-174.
18. Saxena A, Alport EC, Moshynska O, et al. Clonal B cell populations in a minority of patients with Hashimoto's thyroiditis. J Clin Pathol. 2004;57:1258-1263.
19. Cong P, Raffeld M, Teruya-Feldstein J, et al. In situ localization of follicular lymphoma: description and analysis by laser capture microdissection. Blood. 2002;99:3376-3382.
20. Küppers R, Zhao M, Hansmann ML, et al. Tracing B cell development in human germinal centres by molecular analysis of single cells picked from histological sections. EMBO J. 1993;12:4955-4967.
21. Schattner EJ, Casali P. The immune system: structure and function. In: Knowles DM, ed. Neoplastic Hematopathology. 2nd ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2001:74-76.
22. Muller S, Kohler H. B cell superantigens in HIV-1 infection. Int Rev Immunol. 1997;14:339-349.
23. Bellido M, Rubiol E, Ubeda J, et al. Flow cytometry using the monoclonal antibody CD10-PE/Cy5 is a useful tool to identify follicular lymphoma cells. Eur J Haematol. 2001;66:100-106.
24. Sanchez ML, Almeida J, Vidriales B, et al. Incidence of phenotypic aberrations in a series of 467 patients with B chronic lymphoproliferative disorders: basis for the design of specific four-color stainings to be used for minimal residual disease investigation. Leukemia. 2002;16:1460-1469.
25. Cook JR, Craig FE, Swerdlow SH. bcl-2 expression by multicolor flow cytometric analysis assists in the diagnosis of follicular lymphoma in lymph node and bone marrow. Am J Clin Pathol. 2003;119:145-151.
26. Cornfield DB, Mitchell DM, Almasri NM, et al. Follicular lymphoma can be distinguished from benign follicular hyperplasia by flow cytometry using simultaneous staining of cytoplasmic bcl-2 and cell surface CD20. Am J Clin Pathol. 2000;114:258-263.