The effects of flavoxate hydrochloride on voltage-dependent L-type Ca 2+ currents in human urinary bladder

British Journal of Pharmacology

Volumn 146, Issue 1, 2005, Pages 25-32

  Tomoda, Toshihisa ^a   Aishima, Manami ^a   Takano, Naruaki ^a   Nakano, Toshiaki ^a   Seki, Narihito ^a   Yonemitsu, Yoshikazu ^a   Sueishi, Katsuo ^a   Naito, Seiji ^a   Ito, Yushi ^a   Teramoto, Noriyoshi ^a  

^a KYUSHU UNIVERSITY   (Japan)

Author keywords

Flavoxate; Frequency of micturition; Human detrusor myocytes; L type Ca 2+ channels; Overactive bladder; Spasmolytic agent

Indexed keywords

BARIUM; CALCIUM CHANNEL L TYPE; FLAVOXATE;

ADULT; AGED; ARTICLE; BLADDER; CALCIUM CURRENT; CLINICAL ARTICLE; CONTROLLED STUDY; DETRUSOR MUSCLE; DRUG EFFECT; DRUG MECHANISM; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MEMBRANE POTENTIAL; MICTURITION; MUSCLE CONTRACTION; MUSCLE RELAXATION; MUSCLE TONE; PATCH CLAMP; PRIORITY JOURNAL; SMOOTH MUSCLE FIBER;

ADULT; AGED; AGED, 80 AND OVER; BARIUM; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, L-TYPE; FLAVOXATE; HUMANS; MEMBRANE POTENTIALS; MIDDLE AGED; MUSCLE CONTRACTION; MUSCLE RELAXATION; MYOCYTES, SMOOTH MUSCLE; PARASYMPATHOLYTICS; POTASSIUM; URINARY BLADDER;

EID: 30644460756     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/sj.bjp.0706284     Document Type: Article

References (19)

1. ABBIATI, O.A., CESERANI, R., NARDI, D., PIETRA, C. & TESTA, R. (1988). Receptor binding studies of the flavone, REC 15/2053, and other bladder spasmolytics. Pharm. Res., 5, 430-433.
2. ANDERSSON, K.E. (1993). Pharmacology of lower urinary tract smooth muscles and penile erectile tissues. Pharmacol. Rev., 45, 253-308.
3. ANDERSSON, K.E. (2004). New pharmacologic targets for the treatment of the overactive bladder: an update. Urology, 63, 32-41.
4. HAEUSLER, G., LEITICH, H., VAN TROTSENBURG, M., KAIDER, A. & TEMPFER, C.B. (2002). Drug therapy of urinary urge incontinence: a systematic review. Obstet. Gynecol., 100, 1003-1016.
5. HEGDE, S.S., MAMMEN, M. & JASPER, J.R. (2004). Antimuscarinics for the treatment of overactive bladder: current options and emerging therapies. Curr. Opin. Invest. Drugs, 5, 40-49.
6. 2+ channel properties in smooth muscle cells of the urinary bladder from pig and human. Eur. J. Pharmacol., 443, 19-29.
7. KASEDA, M., SATO, A., SATO, Y. & TORIGATA, Y. (1975). Effects of flavoxate hydrochloride (AK-123) on the vesical functions in rats. Clin. Physiol., 5, 540-547.
8. KIMURA, Y., SASAKI, Y., HAMADA, K., FUKUI, H., UKAI, Y., YOSHIKUNI, Y., KIMURA, K., SUGAYA, K. & NISHIZAWA, O. (1996). Mechanisms of the suppression of the bladder activity by flavoxate. Int. J. Urol., 3, 218-227.
9. KOHLER, P.P. & MORALES, P.A. (1968). Cystometric evaluation of flavoxate hydrochloride in normal and neurogenic bladders. J. Urol., 100, 729-730.
10. MALKOWICZ, S.B., WEIN, A.J., RUGGIERI, M.R. & LEVIN, R.M. (1987). Comparison of calcium antagonist properties of antispasmotic agents. J. Urol., 138, 667-670.
11. MCFADZEAN, I. & GIBSON, A. (2002). The developing relationship between receptor-operated and store-operated calcium channels in smooth muscle. Br. J. Pharmacol., 135, 1-13.
12. OKA, M., KIMURA, Y., ITOH, Y., SASAKI, Y., TANIGUCHI, N., UKAI, Y., YOSHIKUNI, Y. & KIMURA, K. (1996). Brain pertussis toxin-sensitive G proteins are involved in the flavoxate hydrochloride-induced suppression of the micturition reflex in rats. Brain Res., 727, 91-98.
13. PÉRÉON, Y., DETTBARN, C., LU, Y., WESTLUND, K.N., ZHANG, J.T. & PALADE, P. (1998). Dihydropyridine receptor isoform expression in adult rat skeletal muscle. Pflügers Arch., 436, 309-314.
14. TERAMOTO, N. & BRADING, A.F. (1996). Activation by levcromakalim and metabolic inhibition of glibenclamide-sensitive K channels in smooth muscle cells of pig proximal urethra. Br. J. Pharmacol., 118, 635-642.
15. + currents in smooth muscle cells from pig urethra. Br. J. Pharmacol., 140, 1341-1350.
16. + channel opener ZD6169 on pig urethral smooth muscle. Br. J. Pharmacol., 134, 1505-1515.
17. UCKERT, S., STIEF, C.G., ODENTHAL, K.P., TRUSS, M.C., LIETZ, B. & JONAS, U. (2000). Responses of isolated normal human detrusor muscle to various spasmolytic drugs commonly used in the treatment of the overactive bladder. Arzneimittelforschung, 50, 456-460.
18. UEHARA, A. & HUME, J.R. (1985). Interactions of organic calcium channel antagonists with calcium channels in single frog atrial cells. J. Gen. Physiol., 85, 621-647.
19. YOSHIMURA, N., SASA, A., YOSHIDA, O. & TAKAORI, S. (1992). Inhibitory effects of Hachimijiogan on micturition reflex via locus coeruleus. Folia Pharmacol. Jpn., 99, 161-166.