Prothrombin G20210A gene variant is not associated with idiopathic portal vein thrombosis in an area endemic for portal vein thrombosis

Annals of Hematology

Volumn 85, Issue 2, 2006, Pages 126-128

  Koshy, Abraham ^a,b   Jeyakumari, Mary ^a,b  

^a ST JOHN'S NATIONAL ACADEMY OF HEALTH SCIENCES   (India)

^b Molecular Biology Unit   (India)

Author keywords

Genetics; Human polymorphism; Portal hypertension

Indexed keywords

DNA; PROTHROMBIN;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DNA EXTRACTION; ENDEMIC DISEASE; FEMALE; GENE FREQUENCY; GENE MUTATION; GENETIC PREDISPOSITION; GENETIC VARIABILITY; HUMAN; IDIOPATHIC DISEASE; INDIA; MALE; PORTAL HYPERTENSION; PORTAL VEIN THROMBOSIS; PREVALENCE; PRIORITY JOURNAL;

ADOLESCENT; ADULT; CHILD; CHILD, PRESCHOOL; FEMALE; GENETIC VARIATION; HUMANS; INDIA; INFANT; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; PORTAL VEIN; PROTHROMBIN; VARIATION (GENETICS); VENOUS THROMBOSIS;

EID: 30644460368     PISSN: 09395555     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00277-005-0020-1     Document Type: Article

References (18)

1. Balta G, Altay C, Gurgey A (2002) PAI-1 gene 4G/5G genotype: A risk factor for thrombosis in vessels of internal organs. Am J Hematol 71:89-93 10.1002/ajh.10192
2. Bhattacharyya M, Makharia G, Kannan M, Ahmed RP, Gupta PK, Saxena R (2004) Inherited prothrombotic defects in Budd-Chiari syndrome and portal vein thrombosis: A study from North India. Am J Clin Pathol 121:844-847 10.1309/F2U1-XBV4-RXYU-AYG0
3. Chamouard P, Pencreach E, Maloisel F, Grunebaum L, Ardizzone JF, Meyer A et al (1999) Frequent factor II G20210A mutation in idiopathic portal vein thrombosis. Gastroenterology 116:144-148 10.1016/ S0016-5085(99)70238-6
4. Cohen J, Edelman RR, Chopra S (1992) Portal vein thrombosis: A review. Am J Med 92:173-182 10.1016/0002-9343(92)90109-O
5. Denninger MH, Chait Y, Casadevall N, Hillaire S, Guillin MC, Bezeaud A et al (2000) Cause of portal or hepatic venous thrombosis in adults: The role of multiple concurrent factors. Hepatology 31:587-591 10.1002/ hep.510310307
6. Erkan O, Bozdayi AM, Disibeyaz S, Oguz D, Ozcan M, Bahar K et al (2005) Thrombophilic gene mutations in cirrhotic patients with portal vein thrombosis. Eur J Gastroenterol Hepatol 17:339-343 10.1097/ 00042737-200503000-00013
7. Gehring NH, Frede U, Neu-Yilik G, Hundsdoerfer P, Vetter B, Hentze MW et al (2001) Increased efficiency of mRNA 3′ end formation: A new genetic mechanism contributing to hereditary thrombophilia. Nat Genet 28:389-392 10.1038/ng578
8. Ghosh K, Shetty S, Madkaikar M, Pawar A, Nair S, Khare A et al (2001) Venous thromboembolism in young patients from western India: A study. Clin Appl Thromb Hemost 7:158-165 11292195
9. Gurgey A, Haznedaroglu IC, Egesel T, Buyukasik Y, Ozcebe OI, Sayinalp N et al (2001) Two common genetic thrombotic risk factors: Factor V Leiden and prothrombin G20210A in adult Turkish patients with thrombosis. Am J Hematol 67:107-111 10.1002/ajh.1087
10. Janssen HL, Meinardi JR, Vleggaar FP, van Uum SH, Haagsma EB, Der Meer FJ et al (2000) Factor V Leiden mutation, prothrombin gene mutation, and deficiencies in coagulation inhibitors associated with Budd-Chiari syndrome and portal vein thrombosis: Results of a case-control study. Blood 96:2364-2368 11001884
11. Koshy A, Deshpande JV, Bahl CM (1984) Clinical differentiation between portal vein thrombosis (PVT), non-cirrhotic portal fibrosis (NCPF) and cirrhosis by discriminant analysis. Indian J Gastroenterol 3:197-198 6386680
12. Madonna P, De S, V, Coppola A, Cerbone AM, Di MG (2001) G20210A prothrombin gene mutation and other trombophilic polymorphisms in patients with portal or hepatic venous thrombosis. Gastroenterology 120:1059-1060 11265667
13. Margaglione M, Brancaccio V, Giuliani N, D'Andrea G, Cappucci G, Iannaccone L et al (1998) Increased risk for venous thrombosis in carriers of the prothrombin G->A20210 gene variant. Ann Intern Med 129:89-93 9669991
14. Martinelli I, Sacchi E, Landi G, Taioli E, Duca F, Mannucci PM (1998) High risk of cerebral-vein thrombosis in carriers of a prothrombin-gene mutation and in users of oral contraceptives. N Engl J Med 338:1793-1797 10.1056/NEJM199806183382502
15. Mohanty D, Shetty S, Ghosh K, Pawar A, Abraham P (2001) Hereditary thrombophilia as a cause of Budd-Chiari syndrome: A study from Western India. Hepatology 34:666-670 10.1053/jhep.2001.27948
16. Poort SR, Rosendaal FR, Reitsma PH, Bertina RM (1996) A common genetic variation in the 3′-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis. Blood 88:3698-3703 8916933
17. Rees DC, Chapman NH, Webster MT, Guerreiro JF, Rochette J, Clegg JB (1999) Born to clot: The European burden. Br J Haematol 105:564-566 10233439
18. Rosendaal FR, Doggen CJ, Zivelin A, Arruda VR, Aiach M, Siscovick DS et al (1998) Geographic distribution of the 20210 G to A prothrombin variant. Thromb Haemost 79:706-708 9569177