Big piece, little piece or: Yes, factor VIII is a protein

Journal of Thrombosis and Haemostasis

Volumn 3, Issue 9, 2005, Pages 1905-1909

  Owen, W G ^a,b  

^a MAYO GRADUATE SCHOOL   (United States)

^b MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD CLOTTING FACTOR 8; SODIUM CHLORIDE;

BLOOD TRANSFUSION; CHEMICAL ANALYSIS; GENETIC ANALYSIS; HEMOPHILIA A; HEMOSTASIS; HUMAN; IMMUNOGENICITY; IN VITRO STUDY; IN VIVO STUDY; MACROMOLECULE; PARTIAL THROMBOPLASTIN TIME; PRIORITY JOURNAL; REVIEW; VON WILLEBRAND DISEASE;

FACTOR VIII; HISTORY, 20TH CENTURY; HISTORY, 21ST CENTURY; HUMANS; PROTEIN BINDING; VON WILLEBRAND DISEASE; VON WILLEBRAND FACTOR;

EID: 30644457934     PISSN: 15387933     EISSN: 15387836     Source Type: Journal    
DOI: 10.1111/j.1538-7836.2005.01247.x     Document Type: Review

References (28)

1. Tuddenham EG. In search of the eighth factor: a personal reminiscence. J Thromb Haemost 2003; 1: 403-9.
2. Veder HA. Is the antihemophilic globulin a protein? Nature 1966; 209: 202.
3. McLester WD, Wagner RH. Antibody to antihemophilic factor and its lack of reaction with hemophilic plasma. Am J Physiol 1965; 208: 499-5071.
4. Hoyer LW. Immunologic properties of antihemophilic factor. Prog Hematol 1973; 8: 191-221.
5. Vehar GA, Davie EW. Preparation and properties of bovine factor VIII (antihemophilic factor). Biochemistry 1980; 19: 401-10.
6. Thelin GM, Wagner RH. Sedimentation of plasma antihemophilic factor. Arch Biochem Biophys 1961; 95: 70-6.
7. Boudreaux HB, Boudreaux RM, Brandon M. Bioassay of a hemostatic factor from peanuts. Arch Biochem Biophys 1960; 89: 276-80.
8. Jackson B, Owen W, Boudreaux HB. Pharmacological and chemical characteristics of peanut extracts effective in hemostasis. Thromb Diath Haemorrh 1966; 16: 257-64.
9. Barrow EM, Amos SM, Heindel C, Graham JB. Separation of the antihemophilic factor (F. 8) from fibrinogen with thrombin and manganese chloride. Proc Soc Exp Biol Med 1966; 121: 1001-5.
10. Barrow EM, Graham JB. Kidney antihemophilic factor. Partial purification and some properties. Biochemistry 1968; 7: 3917-25.
11. Barrow EM, Graham JB. Antihemophilic factor activity isolated from kidneys of normal and hemophilic dogs. Am J Physiol 1971; 220: 1020-4.
12. Barrow EM, Graham JB. Factor VIII (AHF) activity of small size produced by succinylating plasma. Am J Physiol 1972; 222: 134-41.
13. Barrow EM, Lester RH, Johnson AM, Graham JB. Production of antihemophilic (factor VIII) activity from albumin. Am J Physiol 1972; 222: 920-7.
14. Schmer G, Kirby EP, Teller DC, Davie EW. The isolation and characterization of bovine factor VIII (antihemophilic factor). J Biol Chem 1972; 247: 2512-21.
15. Shapiro GA, Andersen JC, Pizzo SV, McKee PA. The subunit structure of normal and hemophilic factor VIII. J Clin Invest 1973; 52: 2198-210.
16. Wagner RH, Roberts HR, Webster WP, Shanbrom E, Brinkhous KM. Glycine-precipitated antihemophilic factor concentrates and their clinical use. Thromb Diath Haemorrh Suppl 1969; 35: 41-8.
17. Webster WP, Roberts HR, Thelin GM, Wagner RH, Brinkhous KM. Clinical use of a new glycine-precipitated antihemophilic fraction. Am J Med Sci 1965; 250: 643-51.
18. Dudman WF. Precipitation of tobacco mosaic virus by macromolecules: a method for estimating molecular volumes. Nature 1966; 211: 1049-50.
19. Owen WG, Wagner RH. Antihemophilic factor. A new method for purification. Thromb Res 1972; 1: 71-88.
20. Weiss HJ, Kochwa S. Molecular forms of antihaemophilic globulin in plasma, cryoprecipitate and after thrombin activation. Br J Haematol 1970; 18: 89-100.
21. 2. Proc Natl Acad Sci USA 1973; 70: 2326-9.
22. Rick ME, Hoyer LW. Immunologic studies of antihemophilic factor (AHF, factor VIII). V. Immunologic properties of AHF subunits produced by salt dissociation. Blood 1973; 42: 737-47.
23. Zimmerman TS, Edgington TS. Factor VIII coagulant activity and factor VIII-like antigen: independent molecular entities. J Exp Med 1973; 138: 1015-20.
24. Aronson DL, Preiss JW, Mosesson MW. Molecular weights of factor VIII (AHF) and factor IX (PTC) by electron irradiation. Thromb Diath Haemorrh 1962; 8: 270-5.
25. Fass DN, Bowie EJ, Owen CA Jr, Mann KG. Stability of porcine factor VIII. Thromb Res 1975; 6: 109-18.
26. Weiss HJ, Sussman II, Hoyer LW. Stabilization of factor VIII in plasma by the von Willebrand factor. Studies on posttransfusion and dissociated factor VIII and in patients with von Willebrand's disease. J Clin Invest 1977; 60: 390-404.
27. Tuddenham EG, Lane RS, Rotblat F, Johnson AJ, Snape TJ, Middleton S, Kernoff PB. Response to infusions of polyelectrolyte fractionated human factor VIII concentrate in human haemophilia A and von Willebrand's disease. Br J Haematol 1982; 52: 259-67.
28. Lethagen S, Berntorp E, Nilsson IM. Pharmacokinetics and hemostatic effect of different factor VIII/von Willebrand factor concentrates in von Willebrand's disease type III. Ann Hematol 1992; 65: 253-9.