Decompression sickness in a swine model: Isobaric denitrogenation and perfluorocarbon at depth

Aviation Space and Environmental Medicine

Volumn 77, Issue 1, 2006, Pages 8-12

  Mahon, Richard T ^a   Dainer, Hugh M ^a   Nelson, John W ^b   Temple, Diana ^a  

^a NAVAL MEDICAL RESEARCH CENTER   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Decompression illness; Oxygen carriers; Saturation diving

Indexed keywords

FLUOROCARBON; INERT GAS; NITROGEN; OXYGEN; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DEATH; DECOMPRESSION SICKNESS; DISEASE SEVERITY; EMULSION; EXPOSURE; ISOBARIC DENITROGENATION; MALE; NONHUMAN; OXYGEN BREATHING; OXYGEN SATURATION; RISK ASSESSMENT; SEIZURE; SWINE;

ANIMALS; DECOMPRESSION; DECOMPRESSION SICKNESS; DISEASE MODELS, ANIMAL; EMULSIONS; FLUOROCARBONS; INFUSIONS, INTRAVENOUS; MALE; NITROGEN; OXYGEN; SEIZURES; SWINE; WEIGHT LOSS;

ANIMALIA; SUS SCROFA;

EID: 30644457087     PISSN: 00956562     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Arieli R, Hershko G. Prediction of central nervous system oxygen toxicity in rats. J Appl Physiol 1994; 77:1903-6.
2. Behnke AR. The isobaric (oxygen window) principle of decompresssion. Transactions of the Annual Conference of the Marine Technology Society; 1967:213-28.
3. th, Gomez JA. Decompression advantages of trimix. Undersea Biomed Res 1978; 5:233-42.
4. Berghage TE, McCracken TM. Use of oxygen for optimizing decompression. Undersea Biomed Res 1979; 6:231-9.
5. Bitterman N. CNS oxygen toxicity. Undersea Hyperbar Med 2004; 31:63-72.
6. Blogg SL, Gennser M, Loveman GA, et al. The effect of breathing hyperoxic gas during simulated submarine escape on venous gas emboli and decompression illness. Undersea Hyperbar Med 2003; 30:163-74.
7. Chavko M, Braisted JC, Outsa NJ, Harabin AL. Role of cerebral blood flow in seizures from hyperbaric oxygen exposure. Brain Res 1998; 791:75-82.
8. Daughterty WP, Lewaseur JE, Sun D, et al. Perfluorocarbon emulsion improves cerebral oxygenation and mitochondrial function after fluid percussion brain injury in rats. Neurosurgery 2004; 54:1223-30.
9. Demchenko IT, Boso AE, Natoli MJ, et al. Measurement of cerebral blood flow in rats and mice by hydrogen clearance during hyperbaric oxygen exposure. Undersea Hyperb Med 1998; 25:147-52.
10. Dietz NM, Joyner MJ, Warner MA. Blood substitutes: fluids, drugs, or miracle solutions? Anesth Analg 1996; 82:390-405.
11. Dromsky DM, Spiess BD, Fahlman A. Treatment of decompression sickness in swine with intravenous perfluorocarbon emulsion. Aviat Space Environ Med 2004; 75:301-5.
12. Dromsky DM, Toner CB, Survanshi S, et al. Natural history of severe decompression sickness after rapid ascent from air saturation in a porcine model. J Appl Physiol 2000; 89:791-8.
13. Faithfull NS, Weers WJ. Perfluorocarbon compounds. Vox Sang 1998; 74:243-8.
14. Floyd TF, Clark JM, Gelfand R, et al. Independent cerebral vasoconstrictive effects of hyperoxia and accompanying arterial hypocapnia at 1 ATA. J Appl Physiol 2003; 95:2453-61.
15. Lillo RS, Himm JF, Weathersby JF, et al. Using animal data to improve prediction of human decompression risk following air saturation dives. J Appl Physiol 2002; 93:216-26.
16. Lutz J, Herrmann G. Perfluorochemicals as a treatment of decompression sickness in rats. Pflugers Arch 1984; 401:174-7.
17. NRC. Guide for the care and use of laboratory animals. Washington, DC: National Academy Press; 1996.
18. Smerz RW. Incidence of oxygen toxicity during the treatment of dysbarism. Undersea Hyperb Med 2004; 31:199-202.
19. Spiess BD, Braverman B, Woronowicz AW, Ivankovish AD. Protection from cerebral air emboli with perfluorocarbons in rabbits. Stroke 1986; 17:1146-9.
20. Vorosmarti J Jr, Barnard EE, Williams J, de G Hanson R. Nitrogen elimination during steady-state hyperbaric exposures. Undersea Biomed Res 1978; 5:243-52.
21. Weathersby PK, Hart BL, Flynn ET, Walker WF. Role of oxygen in the production of human decompression sickness. J Appl Physiol 1987; 63:2380-7.
22. Weathersby PK, Survanshi SS, Parker EC, et al. Estimated DCS risks in pressurized submarine rescue. Bethesda, MD: Naval Medical Research Center; 1999. Report No.: NMRC 99-14.