Spectroscopic analysis of highly concentrated suspensions of bovine somatotropin in sesame oil

Journal of Pharmaceutical Sciences

Volumn 94, Issue 11, 2005, Pages 2487-2495

  Harn, Nicholas R ^a   Jeng, Yunhua N ^b   Kostelc, James G ^b   Middaugh, C Russell ^a,c  

^a UNIVERSITY OF KANSAS   (United States)

^b MONSANTO COMPANY   (United States)

^c UNIVERSITY OF KANSAS   (United States)

Author keywords

Bovine somatotropin; Front surface fluorescence; High concentration

Indexed keywords

GROWTH HORMONE; SESAME SEED OIL;

AQUEOUS SOLUTION; ARTICLE; DRUG STABILITY; DRUG STRUCTURE; FLUORESCENCE SPECTROSCOPY; INFRARED SPECTROSCOPY; PROTEIN AGGREGATION; PROTEIN STABILITY; PROTEIN STRUCTURE; SPECTROSCOPY; TEMPERATURE DEPENDENCE; THERMOSTABILITY;

EID: 30544454328     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.20464     Document Type: Article

References (21)

1. Shire SJ, Shahrokh Z, Liu J. 2004. Challenges in the development of high protein concentration formulations. J Pharm Sci 93:1390-1402.
2. Ross PD, Minton AP. 1977. Analysis of non-ideal behavior in concentrated hemoglobin solutions. J Mol Biol 112:437-452.
3. Dufour E. 2002. Examination of the molecular structure of food products using front-face fluorescence spectroscopy. Am Laboratory (Shelton, CT, United States) 34:50, 52-54, 56.
4. Eisinger J, Flores J. 1979. Front-face fluorometry of liquid samples. Anal Biochem 94:15-21.
5. Sharma VK, Kalonia DS. 2003. Steady-state tryptophan fluorescence spectroscopy study to probe tertiary structure of proteins in solid powders. J Pharm Sci 92:890-899.
6. Schneider AS. 1973. Analysis of optical activity spectra of turbid biological suspensions. Methods Enzymol 27:751-767.
7. Ji TH, Urry DW. 1969. Correlation of light scattering and absorption flattening effects with distortions in the circular dichroism patterns of mitochondrial membrane fragments. Biochem Biophys Res Commun 34:404-411.
8. www.precisiondetectors.com.
9. Kam Z, Rigler R. 1982. Cross-correlation laser scattering. Biophys J 39:7-13.
10. Nicolai T, Urban C, Schurtenberger P. 2001. Light scattering study of turbid heat-set globular protein gels using cross-correlation dynamic light scattering. J Coll Interf Sci 240:419-424.
11. Foster TP. 1999. Somatotropin delivery to farmed animals. Adv Drug Deliv Rev 38:151-165.
12. Lean IJ, Troutt HF, Bruss ML, Baldwin RL. 1992. Bovine somatotropin. Vet Clin North Am Food Anim Pract 8:147-163.
13. Davio SR, Hageman MJ. 1993. Characterization and formulation considerations for recombinantly derived bovine somatotropin. Pharm Biotechnol 5:59-89.
14. Hartman PA, Stodola JD, Harbour GC, Hoogerheide JG. 1986. Reversed-phase high-performance liquid chromatography peptide mapping of bovine somatotropin. J Chromatogr 360:385-395.
15. Secchi C, Borromeo V. 1997. Structure and function of bovine growth hormone. Bovine growth hormone as an experimental model for studies of protein-protein interactions. J Chromatogr B Biomed Sci Appl 688:161-177.
16. Havel HA, Kauffman EW, Elzinga PA. 1988. Fluorescence quenching studies of bovine growth hormone in several conformational states. Biochim Biophys Acta 955:154-163.
17. Havel HA, Chao RS, Haskell RJ, Thamann TJ. 1989. Investigations of protein structure with optical spectroscopy: bovine growth hormone. Anal Chem 61:642-650.
18. Brems DN, Havel HA. 1989. Folding of bovine growth hormone is consistent with the molten globule hypothesis. Proteins 5:93-95.
19. Thamann TJ, Chao RS. 1999. Vibrational spectroscopic studies of solid recombinant bovine growth hormone and related growth hormone analogs. Spectrochim Acta A Mol Biomol Spectrosc 55A:2261-2270.
20. Thamann TJ. 1998. Raman spectroscopic studies of a dimeric form of recombinant bovine growth hormone. Anal Biochem 265:202-207.
21. www.pdb.org.