Use of acyltransferase inhibitors to block vesicular traffic between the ER and Golgi complex

Methods in Enzymology

Volumn 404, Issue , 2005, Pages 115-125

  Brown, William J ^a   Schmidt, John A ^a  

^a Cornell University ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,2 DIMETHYL N (2,4,6 TRIMETHOXYPHENYL)DODECANAMIDE; ACYLTRANSFERASE; ACYLTRANSFERASE INHIBITOR; COAT PROTEIN COMPLEX II; LECIMIBIDE; LYSOPHOSPHOLIPID ACYLTRANSFERSE; PFK 058035; TRANSFERRIN RECEPTOR; TS 962; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL BUDDING; CELL CULTURE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; EUKARYOTIC CELL; GOLGI COMPLEX; INTRACELLULAR MEMBRANE; MAMMAL CELL; MEMBRANE TRANSPORT; MEMBRANE VESICLE; NONHUMAN; PRIORITY JOURNAL;

ANIMALIA; EUKARYOTA; MAMMALIA;

EID: 30544444271     PISSN: 00766879     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0076-6879(05)04012-7     Document Type: Review

References (23)

1. Bannykh S.I., Nishimura N., and Balch W.E. Getting into the Golgi Trends Cell. Biol. 8 1998 21 25
2. 2) enzymes in membrane trafficking: Mediators of membrane shape and function Traffic 4 2003 214 221
3. Carcedo C.H., Bonazzi M., Spano S., Turacchio G., Colanzi A., Luini A., and Corda D. Mitotic Golgi partitioning is driven by the membrane-fissioning protein CtBP3/BARS Science 305 2004 93 96
4. Carr T.P., Hamilton R.L. Jr., and Rudel L.L. ACAT inhibitors decrease secretion of cholesteryl esters and apolipoprotein B by perfused livers of African green monkeys J. Lipid Res. 36 1995 25 36
5. Chambers K., and Brown W.J. Characterization of a novel CI-976-sensitive lysophospholipid acyltransferase that is associated with the Golgi complex Biochem. Biophys. Res. Commun. 313 2004 681 686
6. Chambers K., Judson B., and Brown W.J. A unique lysophospholipid acyltransferase (LPAT) antagonist, CI-976, affects secretory and endocytic membrane trafficking pathways J. Cell Sci. 118 2005 3061 3071
7. Corda D., Hidalgo Carcedo C., Bonazzi M., Luini A., and Spano S. Molecular aspects of membrane fission in the secretory pathway Cell. Mol. Life Sci. 59 2002 1819 1832
8. Davidson H.W., and Balch W.E. Differential inhibition of multiple vesicular transport steps between the endoplasmic reticulum and trans Golgi network J. Biol. Chem. 268 1993 4216 4226
9. 2 activity is required for Golgi complex and trans Golgi network membrane tubulation Proc. Natl. Acad. Sci. USA 95 1998 8642 8647
10. Drecktrah D., Chambers K., Racoosin E.L., Cluett E.B., Gucwa A., Jackson B., and Brown W.J. Inhibition of a Golgi complex lysophospholipid acyltransferase induces membrane tubule formation and retrograde trafficking Mol. Biol. Cell 14 2003 3459 3469
11. Fabbri M., Bannykh S., and Balch W.E. Export of protein from the endoplasmic reticulum is regulated by a diacylglycerol/phorbol ester binding protein J. Biol. Chem. 269 1994 26848 26857
12. Field F.J., Albright E., and Mathur S. Inhibition of acylcoenzyme A: Cholesterol acyltransferase activity by PD128O42: Effect on cholesterol metabolism and secretion in CaCo-2 cells Lipids 26 1991 1 8
13. Fuller N., and Rand R.P. The influence of lysolipids on the spontaneous curvature and bending elasticity of phospholipid membranes Biophys. J. 81 2001 243 254
14. Homan R., and Hamelehle K.L. Influence of membrane partitioning on inhibitors of membrane-bound enzymes J. Pharm. Sci. 90 2001 1859 1867
15. Krause B.R., Anderson M., Bisgaier C.L., Bocan T., Bousley R., De Hart P., Essenburg A., Hamelehle K., Homan R., Kieft K., McNally W., Stanfield R., and Newton R.S. In vivo evidence that the lipid-regulating activity of the ACAT inhibitor CI-976 in rats is due to inhibition of both intestinal and liver ACAT J. Lipid. Res. 34 1993 279 294
16. Leung D.W. The structure and functions of human lysophosphatidic acid acyltransferases Front. Biosci. 6 2001 D944 D953
17. Lewin T.M., Wang P., and Coleman R.A. Analysis of amino acid motifs diagnostic for the sn-glycerol-3-phosphate acyltransferase reaction Biochemistry 38 1999 5764 5771
18. Patankar S.J., and Jurs P.C. Prediction of IC50 values for ACAT inhibitors from molecular structure J. Chem. Inf. Comput. Sci. 40 2000 706 723
19. Roth B.D., Blankley C.J., Hoefle M.L., Holmes A., Roark W.H., Trivedi B.K., Essenburg A.D., Kieft K.A., Krause B.R., and Stanfield R.L. Inhibitors of acyl-CoA:Cholesterol acyltransferase. 1. Identification and structure-activity relationships of a novel series of fatty acid anilide hypocholesterolemic agents J. Med. Chem. 35 1992 1609 1617
20. Rowe T., Aridor M., McCaffery J.M., Plutner H., Nuoffer C., and Balch W.E. COPII vesicles derived from mammalian endoplasmic reticulum microsomes recruit COPI J. Cell. Biol. 135 1996 895 911
21. Schmidt A., Wolde M., Thiele C., Fest W., Kratzin H., Podtelejnikov A.V., Witke W., Huttner W.B., and Soling H.D. Endophilin I mediates synaptic vesicle formation by transfer of arachidonate to lysophosphatidic acid Nature 401 1999 133 141
22. Sinz M.W., Black A.E., Bjorge S.M., Holmes A., Trivedi B.K., and Woolf T.F. In vitro and in vivo disposition of 2,2-dimethyl-N-(2,4,6-trimethoxyphenyl) dodecanamide (CI-976). Identification of a novel five-carbon cleavage metabolite in rats Drug Metab. Dispos. 25 1997 123 130
23. Weigert R., Silletta M.G., Spano S., Turacchio G., Cericola C., Colanzi A., Senatore S., Mancini R., Polishchuk E.V., Salmona M., Facchiano F., Burger K.N., Mironov A., Luini A., and Corda D. CtBP/BARS induces fission of Golgi membranes by acylating lysophosphatidic acid Nature 402 1999 429 433