Prospective evaluation of concurrent paclitaxel and radiation therapy after adjuvant doxorubicin and cyclophosphamide chemotherapy for Stage II or III breast cancer

International Journal of Radiation Oncology Biology Physics

Volumn 64, Issue 2, 2006, Pages 496-504

  Burstein, Harold J ^a,c   Bellon, Jennifer R ^a   Galper, Sharon ^a   Lu, Hsiao Ming ^a   Kuter, Irene ^b   Taghian, Alphonse G ^b   Wong, Julia ^a   Gelman, Rebecca ^a   Bunnell, Craig A ^a   Parker, Leroy M ^a   Garber, Judy E ^a   Winer, Eric P ^a   Harris, Jay R ^a   Powell, Simon N ^b  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

Breast cancer; Concurrent; Paclitaxel; Radiotherapy; Taxane

Indexed keywords

CHEMOTHERAPY; COMPUTER SIMULATION; ONCOLOGY; PATIENT TREATMENT; SURGERY; TOXICITY;

BREAST CANCER; CONCURRENT; PACLITAXEL; TAXANE;

RADIOTHERAPY;

CORTICOSTEROID; CYCLOPHOSPHAMIDE; DOXORUBICIN; PACLITAXEL;

ADJUVANT CHEMOTHERAPY; ARTHRALGIA; ARTICLE; BREAST CANCER; BREAST SURGERY; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER STAGING; CELLULITIS; CLINICAL ARTICLE; CLINICAL PROTOCOL; CLINICAL TRIAL; COHORT ANALYSIS; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; COUGHING; DEEP VEIN THROMBOSIS; DESQUAMATION; DIARRHEA; DRUG DOSE REGIMEN; DRUG SAFETY; DYSPEPSIA; DYSPNEA; FATIGUE; FEASIBILITY STUDY; FEBRILE NEUTROPENIA; FEMALE; FEVER; GRANULOCYTOPENIA; HEART DISEASE; HUMAN; HYPERGLYCEMIA; HYPERSENSITIVITY REACTION; HYPERTENSION; LUNG EMBOLISM; LUNG TOXICITY; MYALGIA; NAUSEA; NEUROTOXICITY; PARESTHESIA; PHASE 1 CLINICAL TRIAL; PRIORITY JOURNAL; PROSPECTIVE STUDY; RADIATION DERMATITIS; RADIATION FIELD; RADIATION PNEUMONIA; SENSORY DYSFUNCTION; SENSORY NEUROPATHY; SKIN BLEEDING; SKIN NECROSIS; SKIN TOXICITY; SKIN ULCER; STOMATITIS; THROMBOCYTOPENIA; TREATMENT FAILURE; VOMITING; WEAKNESS;

ADULT; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BREAST NEOPLASMS; CHEMOTHERAPY, ADJUVANT; CYCLOPHOSPHAMIDE; DOXORUBICIN; DRUG ADMINISTRATION SCHEDULE; FEASIBILITY STUDIES; FEMALE; HUMANS; PACLITAXEL; PROSPECTIVE STUDIES; RADIATION PNEUMONITIS; RADIATION-SENSITIZING AGENTS; RADIOTHERAPY DOSAGE; RADIOTHERAPY, ADJUVANT;

EID: 30544442380     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2005.07.975     Document Type: Article

References (29)

1. A. Recht, S.E. Come, I.C. Henderson The sequencing of chemotherapy and radiation therapy after conservative surgery for early-stage breast cancer N Engl J Med 334 1996 1356 1361
2. J.R. Bellon, S. Come, R.S. Gelman Sequencing of chemotherapy and radiation therapy in early stage breast cancer Updated results of a prospective randomized trial J Clin Oncol 23 2005 1934 1940
3. N. Hebert-Croteau, C.R. Freeman, J. Latreille, J. Brisson Delay in adjuvant radiation treatment and outcomes of breast cancer - a review Breast Cancer Res Treat 74 2002 77 94
4. C.I. Sartor, T.J. Fitzgerald, F. Laurie Effect of addition of adjuvant paclitaxel on radiotherapy delivery and locoregional control for node positive breast cancer in CALGB 9344 Proc Am Soc Clin Oncol 22 2003 10 (Abstract 38)
5. A. Recht, S.E. Come, R.S. Gelman Integration of conservative surgery, radiotherapy, and chemotherapy for the treatment of early-stage, node-positive breast cancer Sequencing, timing, and outcome J Clin Oncol 9 1991 1662 1667
6. T.A. Bucholz, M.M. Austin-Seymour, R.E. Moe Effect of delay in radiation in combined modality treatment of breast cancer Int J Radiat Oncol Biol Phys 26 1993 23 35
7. A. Dubey, A. Recht, S.E. Come Concurrent CMF and radiation therapy for early stage breast cancer Results of a pilot study Int J Radiat Oncol Biol Phys 45 1999 877 884
8. D.A. Markiewicz, K.R. Fox, D.J. Schultz Concurrent chemotherapy and radiation for breast conservation treatment of early-stage breast cancer Cancer J Sci Am 4 1998 185 193
9. G. Macquart-Moulin, P. Viens, D. Genre Concomitant chemoradiotherapy for patients with non-metastatic breast carcinoma. Side effects, quality of life, and daily organization Cancer 85 1999 2190 2199
10. A.L. Abner, A. Recht, F.A. Vicini Cosmetic results after surgery, chemotherapy, and radiation therapy for early breast cancer Int J Radiat Oncol Biol Phys 21 1991 331 338
11. D.A. Markiewicz, D.J. Schultz, J.A. Haas The effects of sequence and type of chemotherapy and radiation therapy on cosmesis and complications after breast conservation therapy Int J Radiat Oncol Biol Phys 35 1996 661 668
12. C. Nogues, J.R. Garbay, D. Serin Sequential or simultaneous chemo-radiotherapy in operable breast cancer A French multicentric phase III study - state of inclusions Eur J Cancer 34 1998 44 45 [Abstract]
13. G. Calais, C. Berger, A. Fourquet Sequencing radiation therapy and adjuvant chemotherapy after conservative breast surgery for patients with Stage I and II breast carcinoma Preliminary results (acute toxicity and treatment compliance) of a randomized trial comparing RT with concomitant administration of CT versus sequential treatment Radiother Oncol 48 1998 125 [Abstract]
14. L. Milas, M.M. Milas, K.A. Mason Combination of taxanes with radiation Preclinical studies Semin Radiat Oncol 9 1999 12 26
15. H. Choy Taxanes in combined modality therapy for solid tumors Crit Rev Oncol Hematol 37 2001 237 247
16. I.C. Henderson, D. Berry, G. Demetri Improved outcomes from adding sequential paclitaxel but not from escalating doxorubicin dose in an adjuvant chemotherapy regimen for patients with node-positive primary breast cancer J Clin Oncol 21 2003 976 983
17. B. Fisher, A.M. Brown, N.V. Dimitrov Two months of doxorubicin- cyclophosphamide with and without interval reinduction therapy compared with 6 months of cyclophosphamide, methotrexate, and fluorouracil in positive-node breast cancer patients with tamoxifen-nonresponsive tumors Results from the National Surgical Adjuvant Breast and Bowel Project B-15 J Clin Oncol 8 1990 1483 1496
18. J.D. Cox, J. Stetz, T.F. Pajak Toxicity criteria of the Radiation Therapy Oncology Research Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC) Int J Radiat Oncol Biol Phys 31 1995 1341 1346
19. J.R. Bellon, K.L. Lindsley, G.K. Ellis Concurrent radiation therapy and paclitaxel or docetaxel chemotherapy in high-risk breast cancer Int J Radiat Oncol Biol Phys 48 2000 393 397
20. A.G. Taghian, S.I. Assaad, A. Niemierko Risk of pneumonitis in breast cancer patients treated with radiation therapy and combination chemotherapy with paclitaxel J Natl Cancer Inst 93 2001 1806 1811
21. Y.M. Hanna, K.L. Baglan, J.S. Stromgber, F.A. Vicini, D.A. Decker Acute and subacute toxicity associated with concurrent adjuvant radiation therapy and paclitaxel in primary breast cancer therapy Breast J 8 2002 149 153
22. N. Ellerbroek, S. Martino, B. Mautner, M.L. Tao, C. Rose, L. Botnick Breast-conserving therapy with adjuvant paclitaxel and radiation therapy Feasibility of concurrent treatment Breast J 9 2003 74 78
23. T.I. Lingos, A. Recht, F. Vicini, A. Abner, B. Silver, J.R. Harris Radiation pneumonitis in breast cancer patients treated with conservative surgery and radiation therapy Int J Radiat Oncol Biol Phys 21 1991 355 360
24. T.K. Yu, G.J. Whitman, H.D. Thames Clinically relevant pneumonitis after sequential paclitaxel-based chemotherapy and radiation in breast cancer patients J Natl Cancer Inst 96 2004 1676 1681
25. P.A.R.M. Lind, L.B. Marks, P.H. Hardenbergh Technical factors associated with radiation pneumonitis after local ± regional radiation therapy for breast cancer Int J Radiat Oncol Biol Phys 52 2002 137 143
26. C.H. Takimoto, E.K. Rowinsky Dose-intense paclitaxel Déjà à vu all over again? J Clin Oncol 21 2003 2810 2814
27. H. Gelderblom, K. Mross, A.J. Ten Tije Comparative pharmacokinetics of unbound paclitaxel during 1-hour and 3-hour infusions J Clin Oncol 20 2002 574 581
28. S. Formenti, M. Volm, K.A. Skinner Preoperative twice-weekly paclitaxel with concurrent radiation therapy followed by surgery and postoperative doxorubicin-based chemotherapy in locally advanced breast cancer A phase I/II trial J Clin Oncol 21 2003 864 870
29. M.L. Citron, D.A. Berry, C. Cirrincione Randomized trial of dose-dense versus conventionally scheduled and sequential versus concurrent combination chemotherapy as postoperative adjuvant treatment of node-positive primary breast cancer First report of Intergroup Trial C9741/Cancer and Leukemia Group B Trial 9741 J Clin Oncol 21 2003 1431 1439