Synthesis and antitumor activity of isoandrographolide compounds

Journal of China Pharmaceutical University

Volumn 36, Issue 6, 2005, Pages 504-510

  Wang, Xin Yang ^a,b   Xu, Hao ^a   Wu, Xiao Ming ^a   Huang, Wen Long ^a   Zhou, Jin Pei ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b NANTONG UNIVERSITY   (China)

Author keywords

Antitumor activity; Isoandrographolide; Synthesis

Indexed keywords

3,19 DI[(N BUTYLAMINE)CARBONYL CARBOXYL] O ISOANDROGRAPHOLIDE; ALCOHOL; AMINE; ANDROGRAPHOLIDE; ANTINEOPLASTIC AGENT; CHLORIDE; ISOANDROGRAPHOLIDE DIOXALYL AMIDE DERIVATIVE; ISOANDROGRAPHOLIDE DIOXALYL ESTER DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DRUG IDENTIFICATION; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; INFRARED RADIATION; MASS SPECTROMETRY; PROTON NUCLEAR MAGNETIC RESONANCE;

EID: 30544437595     PISSN: 10005048     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. Chinese source. 1977.1 580-1 584.
2. Chang RS, Ding L, Chen GQ, et al. Dehydroandrographolide succinic acid monoester as an inhibitor against the human immunodeficiency virus[J]. Proc Soc Exp Biol Med, 1991,197(1):59-66.
3. Matsuda T, Kuroyangagi M, Sugiyama S, et al. Cell differentiation-inducing diterpenes from Andrographis paniculata Nees [J]. Chem Pharm Bull, 1994,42(6):1 216-1 225.
4. Chen PS. Chinese source. (Pract J Integration Chin West Med), 1991,1(4):176.
5. Sun ZH, Chen ZL, Xu LC, Chinese source. 2001,11(2):88-89.
6. Xu LC. Chinese source. 1999.457.
7. Babash JG, Ma XF. Use of andrographolide compounds to treat or prevent pathogenicity of diseases[P]. WO 9617605, 1996-06-13.
8. Meng ZM. Chinese source. (Acta Pharm Sin), 1981,16(8):571-575.
9. Srinivas N, Rajagopal S, Akella V, et al. Compounds having anticancer activity: process for their preparation and pharmaceutical compositions containing them[P]. US 0016324A1, 2002-02-07.
10. Misbah A, Farooq B, Rajesh KG, et al. A novel diterpenoid lactone-based scaffold for the generation of combinatorial libraries [J]. Tetrahedron Lett, 2001,42(40):7 119-7 121.
11. Wagner H, Wolff. Natural products and drugs with pharmacological or biological or therapeutical activity[M]. New Yrok, 1977.157-165.
12. Cava MP, Chan WR, Stein RP, et al. Andrographolide: Futher transformations and stereochemical evidence; the structure of isoandrographolide[J]. Tetrahedron, 1965,21(9):2 617-2 632.