Bone disease after kidney transplantation

Advances in Chronic Kidney Disease

Volumn 13, Issue 1, 2006, Pages 35-46

  Zisman, Anna L ^a   Sprague, Stuart M ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Bone disease; Kidney transplantation; Osteoporosis; Renal osteodystrophy

Indexed keywords

25 HYDROXYVITAMIN D; ALENDRONIC ACID; AZATHIOPRINE; BISPHOSPHONIC ACID DERIVATIVE; CALCINEURIN INHIBITOR; CALCITONIN; CALCIUM; CINACALCET; CYCLOSPORIN; CYCLOSPORIN A; DACLIZUMAB; DEFLAZACORT; ESTROGEN; GLUCOCORTICOID; IBANDRONIC ACID; IMMUNOSUPPRESSIVE AGENT; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PAMIDRONIC ACID; PLACEBO; PREDNISOLONE; PREDNISONE; RALOXIFENE; RAPAMYCIN; STEROID; TACROLIMUS; UNINDEXED DRUG; VITAMIN D; VITAMIN D DERIVATIVE; VITAMIN D RECEPTOR; ZOLEDRONIC ACID;

BONE BIOPSY; BONE DENSITY; BONE DISEASE; CHRONIC KIDNEY DISEASE; DRUG MEGADOSE; GRAFT SURVIVAL; HIP FRACTURE; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY TRANSPLANTATION; MINERAL DEFICIENCY; NONHUMAN; OSTEOLYSIS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RENAL OSTEODYSTROPHY; REVIEW; RISK FACTOR; SIDE EFFECT; TREATMENT OUTCOME;

EID: 30444450414     PISSN: 15485595     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.ackd.2005.10.008     Document Type: Article

References (111)

1. C.O. Stehman-Breen, D.J. Sherrard, A.M. Alem Risk factors for hip fracture among patients with end-stage renal disease Kidney Int 58 2000 2200 2205
2. A.M. Alem, D.J. Sherrard, D.L. Gillen Increased risk of hip fracture among patients with end-stage renal disease Kidney Int 58 2000 396 399
3. A.M. Ball, D.L. Gillen, D. Sherrard Risk of hip fracture among dialysis and renal transplant recipients JAMA 288 2002 3014 3018
4. E. Elmstedt, T. Svahn Skeletal complications following renal transplantation Acta Orthop Scand 52 1981 279 286
5. J.K. Davidson, D. Tsakiris, J.D. Briggs Osteonecrosis and fractures following renal transplantation Clin Radiol 36 1985 27 35
6. R.R. Ramsey-Goldman, J.E. Dunn, D.D. Dunlop Increased risk of fracture in patients receiving solid organ transplants J Bone Miner Res 14 1999 456 463
7. D.J. Arlen, K. Lambert, G. Ioannidis Treatment of established bone loss after renal transplantation with etidronate Transplantation 71 2001 669 673
8. E.A. O'Shaughnessy, D.C. Dahl, C.L. Smith Risk factors for fractures in kidney transplantation Transplantation 74 2002 362 366
9. S. Durieux, L. Mercadal, P. Orcel Bone mineral density and fracture prevalence in long-term kidney graft recipients Transplantation 74 2002 496 500
10. W.H. Grotz, F.A. Mundinger, B. Gugel Bone fracture and osteodensitometry with dual energy x-ray absorptiometry in kidney transplant recipients Transplantation 58 1994 912 915
11. C.R. Parker, A.J. Freemont, P.J. Blackwell Cross-sectional analysis of renal transplantation osteoporosis J Bone Miner Res 14 1999 1943 1951
12. S. Patel, J.T.C. Kwan, E. McCloskey Prevalence and causes of low bone density and fractures in kidney transplant patients J Bone Miner Res 16 2001 1863 1870
13. A. D'Angelo, L. Calo, S. Giannini Parathyroid hormone and bone metabolism in kidney-transplanted patients Clin Nephrol 53 2000 19 22
14. J.H. Nam, J.I. Moon, S.S. Chung Prevalence and risk factors for vertebral fractures in renal transplants Transplant Proc 32 2000 1877
15. M.Y. Chiu, S.M. Sprague, D.S. Bruce Analysis of fracture prevalence in kidney-pancreas allograft recipients J Am Soc Nephrol 9 1998 677 683
16. U. Nisbeth, E. Lindh, S. Ljunghall Increased fracture rate in diabetes mellitus and females after renal transplantation Transplantation 67 1999 1218 1222
17. K.C. Abbott, R.J. Oglesby, I.O. Hypolite Hospitalizations for fractures after renal transplantation in the United States Epidemiology 11 2001 450 457
18. J.T. Kwan, M.K. Almond, K. Evans Changes in total body bone mineral content and regional bone mineral density in renal patients following renal transplantation Miner Electrolyte Metab 18 1992 166 168
19. J. Feber, P. Cochat, P. Braillon Bone mineral density after renal transplantation in children J Pediatr 6 1994 870 875
20. H.D. McIntyre, B. Menzies, R. Rigby Long-term bone loss after renal transplantation Comparison of immunosuppressive regimens Clin Transplant 9 1995 20 24
21. A. Torres, M. Machado, M.T. Concepcion Influence of vitamin D receptor genotype on bone mass changes after renal transplantation Kidney Int 50 1996 1726 1733
22. Y.S. Yun, B.J. Kim, S.P. Hong Changes of bone metabolism indices in patients receiving immunosuppressive therapy including low doses of steroids after renal transplantation Transplant Proc 28 1996 1561 1564
23. M.S. Kim, Y.S. Kim, S.K. Lim Effect of deflazacort on bone mineral density in renal transplant recipients Transplant Proc 30 1998 3041 3042
24. K. Lippuner, J.-P. Casez, F.F. Horber Effects of deflazacort versus prednisone on bone mass, body composition and lipid profile A randomized double blind study in kidney transplant patients J Clin Endocrinol Metab 83 1998 3795 3802
25. Y.F.C. Smets, J.W. van der Pijl, J. Ringers Pattern of bone loss after simultaneous pancreas-kidney transplantation A prospective study Transplant Proc 30 1998 326
26. I. Isiklar, O. Akin, A. Demirag Changes in bone mineral density after renal transplantation Transplant Proc 30 1998 814-185
27. A. Moreno, J.V. Torregrosa, F. Pons Bone mineral density after renal transplantation Transplant Proc 31 1999 2322 2323
28. S.L.S. Fan, M.K. Almond, E. Ball Pamidronate therapy as prevention of bone loss following renal transplantation Kidney Int 57 2000 684 690
29. J.-H. Nam, J.I. Moon, S.-S. Chung Pamidronate and calcitriol trial for the prevention of early bone loss after renal transplantation Transplant Proc 32 2000 1876
30. Y. Kokado, S. Takahara, N. Ichimaru Factors influencing vertebral bone density after renal transplantation Transpl Int 13 2000 S431 S435
31. E. Goffin, J.-P. Devogelaer, A. Lalaoui Tacrolimus and low-dose steroid immunosuppression preserves bone mass after renal transplantation Transpl Int 15 2002 73 80
32. B.A. Julian, D.A. Laskow, J. Dubovsky Rapid loss of vertebral mineral density after renal transplantation N Engl J Med 325 1991 544 550
33. F.F. Horber, J.P. Casez, U. Steiger Changes in bone mass early after kidney transplantation J Bone Miner Res 9 1994 1 9
34. M.K. Almond, J.T. Kwan, K. Evans Loss of regional bone mineral density in the first 12 months following renal transplantation Nephron 66 1994 52 57
35. W. Grotz, C. Nagel, D. Poeschel Effect of ibandronate on bone loss and renal function after kidney transplantation J Am Soc Nephrol 12 2001 1530 1537
36. W.H. Grotz, F.A. Mundinger, B. Gugel Bone mineral density after kidney transplantation. A cross-sectional study in 190 graft recipients up to 20 years after transplantation Transplantation 59 1995 982 986
37. A. Ugur, N. Guvener, I. Isiklar Osteoporosis after renal transplantation Single center experience Transplantation 71 2001 645 649
38. E. Nowacka-Cieciura, M. Durlik, T. Cieciura Steroid withdrawal after renal transplantation-risks and benefits Transplant Proc 34 2002 560 563
39. A. Aroldi, A. Tarantino, G. Montagnino Effects of three immunosuppressive regimens on vertebral bone density in renal transplant recipients A prospective study Transplantation 63 1997 380 386
40. B. Bagni, P. Gilli, A. Cavallini Continuing loss of vertebral mineral density in renal transplant recipients Eur J Nucl Med 21 1994 108 112
41. G. Hurst, R. Alloway, D. Hathaway Stabilization of bone mass after renal transplant with preemptive care Transplant Proc 30 1998 1327 1328
42. K. Yazawa, T. Ishikawa, Y. Ichikawa Positive effects of kidney transplantation on bone mass Transplant Proc 30 1998 3031 3033
43. H. Kim, K. Chang, T. Lee Bone mineral density after renal transplantation Transplant Proc 30 1998 3029 3030
44. A.M. Cueto-Manzano, S. Konel, A.J. Freemont Effect of 1,25-dihydroxyvitamin D3 and calcium carbonate on bone loss associated with long-term renal transplantation Am J Kidney Dis 35 2000 227 236
45. W.H. Grotz, L.C. Rump, A. Niessen Treatment of osteopenia and osteoporosis after kidney transplantation Transplantation 66 1998 1004 1008
46. D. Cruz, J.J. Wysolmerski, H. Brickel Parameters of high bone-turnover predict bone loss in renal transplant patients A longitudinal study Transplantation 72 2001 83 88
47. V.M. Brandenburg, M. Ketteler, W.J. Fassbender Development of lumbar bone mineral density in the late course after kidney transplantation Am J Kidney Dis 40 2002 1066 1074
48. Y.F. Smets, J.W. van der Pilj, J.W. de Fijter Low bone mass and high incidence of fractures after successful simultaneous pancreas-kidney transplantation Nephrol Dial Transplant 13 1998 1250 1255
49. F. Velasquez-Forero, A. Mondragon, B. Herrero Adynamic bone lesion in renal transplant recipients with normal renal function Nephrol Dial Transplant 11 suppl 3 1996 58 64
50. W.E. Braun, B.J. Richmond, D.A. Protiva The incidence and management of osteoporosis, gout, and avascular necrosis in recipients of renal allografts functioning more than 20 years (level 5A) treated with prednisone and azathioprine Transplant Proc 31 1999 1366 1369
51. R.G. Carlini, E. Rojas, J.R. Weisinger Bone disease in patients with long-term renal transplantation and normal renal function Am J Kidney Dis 36 2000 160 166
52. J. Heaf, E. Tvedgaard, I.-L. Kanstrup Bone loss after renal transplantation Role of hyperparathyroidism, acidosis, cyclosporine and systemic disease Clin Transplant 14 2000 457 463
53. E.N. Ellis, D.M. Floyd-Gimon, P.L. Berry Risk factors for bone mineral density loss in pediatric renal transplant patients Pediatr Transplantat 4 2000 146 150
54. A.V. Cayco, J. Wysolmerski, C. Simpson Posttransplant bone disease Evidence for a high bone resorption state Transplantation 70 2000 1722 1728
55. D. Kovac, J. Lindic, A. Kandus Bone mineral density in kidney transplant recipients Transplant Proc 33 2001 3668 3669
56. V. Pichette, A. Bonnardeaux, L. Prudhomme Long-term bone loss in kidney transplant recipients A cross-sectional and longitudinal study Am J Kidney Dis 28 1996 105 114
57. T. Wolpaw, C.L. Deal, S. Fleming-Brooks Factors influencing vertebral bone density after renal transplantation Transplantation 58 1994 1186 1189
58. I. Boiskin, S. Epstein, F. Ismail Serum osteocalcin and bone mineral metabolism following successful renal transplantation Clin Nephrol 31 1989 316 322
59. H. Schmidt, H. Stracke, H. Schatz Osteocalcin serum levels in patients following renal transplantation Klin Wochenschr 67 1989 297 303
60. H.H. Saha, K.T. Salmela, P.J. Ahonen Sequential changes in vitamin D and calcium metabolism after successful renal transplantation Scand J Urol Nephrol 28 1994 21 27
61. W. Withold, S. Degenhardt, M. Heins Monitoring of bone resorption after renal transplantation by measuring the urinary excretion of pyridinium cross-links Eur J Clin Chem Clin Biochem 33 1995 15 21
62. M.R. Bonnin, M.T. Gonzalez, J.M. Grino Changes in serum osteocalcin levels in the follow-up of kidney transplantation Ann Clin Biochem 34 1997 651 655
63. D. Barbarykin, I. Adamsone, D. Amerika Disorders of calcium metabolism at various times after renal transplantation Ann Transplant 4 1999 46 53
64. V. Kusec, R. Smalcelj, S. Cvijetic Determinants of reduced bone mineral density and increased bone turnover after kidney transplantation Cross-sectional study Croat Med J 41 2000 396 400
65. F.P. Westeel, H. Mazouz, F. Ezaitouni Cyclosporine bone remodeling effect prevents steroid osteopenia after kidney transplantation Kidney Int 58 2000 1788 1796
66. T. Cundy, J.A. Kanis Rapid suppression of plasma alkaline phosphatase activity after renal transplantation in patients with osteodystrophy Clin Chim Acta 164 1987 285 291
67. J.P. van Straalen, E. Sanders, M.F. Prummel Bone-alkaline phosphatase as indicator of bone formation Clin Chim Acta 201 1991 27 33
68. W. Withold, W. Friedrich, S. Degenhardt Serum bone alkaline phosphatase is superior to plasma levels of bone matrix proteins for assessment of bone metabolism in patients receiving renal transplants Clin Chim Acta 261 1997 105 115
69. W. Withold, S. Degenhardt, B. Grabensee Comparison between serum levels of bone alkaline phosphatase and the carboxy-terminal propeptide of type I procollagen as markers of bone formation in patients following renal transplantation Clin Chim Acta 239 1995 143 151
70. S. Epstein, H. Traberg, R. Raja Serum and dialysate osteocalcin levels in hemodialysis and peritoneal dialysis patients and after renal transplantation J Clin Endocrinol Metab 60 1985 1253 1256
71. G.S. Reusz, A.J. Szabo, F. Peter Bone metabolism and mineral density following renal transplantation Arch Dis Child 83 2000 146 151
72. P. Pietschmann, A. Vychytil, W. Woloszczuk Bone metabolism in patients with functioning kidney grafts Increased serum levels of osteocalcin and parathyroid hormone despite normalization of kidney function Nephron 59 1991 533 536
73. J.A. Amado, J.A. Riancho, A.L. De Francisco Hyperparathyroidism is responsible for the increased levels of osteocalcin in patients with normally functioning kidney grafts Nephron 52 1989 209 215
74. G. Dumoulin, B. Hory, N.U. Nguyen No trend toward a spontaneous improvement of hyperparathyroidism and high bone turnover in normocalcemic long-term renal transplant recipients Am J Kidney Dis 29 1997 746 753
75. S. Giannini, A. D'Angelo, G. Carraro Persistently increased bone turnover and low bone density in long-term survivors to kidney transplantation Clin Nephrol 56 2001 353 363
76. V.A. Briner, G. Thiel, M.C. Monier-Faugere Prevention of cancellous bone loss but persistence of renal bone disease despite normal 1,25 vitamin D levels two years after kidney transplantation Transplantation 59 1995 1393 1400
77. R.G. Carlini, E. Rojas, A. Arminio What are the bone lesions in patients with more than four years of a functioning renal transplant? Nephrol Dial Transplant 13 suppl 3 1998 103 104
78. A.M. Cueto-Manzano, S. Konel, A.J. Hutchison Bone loss in long-term renal transplantation Histopathology and densitometry analysis Kidney Int 55 1999 2021 2029
79. C.P. Sanchez, I.B. Salusky, B.D. Kuizon Bone disease in children and adolescents undergoing successful renal transplantation Kidney Int 53 1998 1358 1364
80. J.R. Weisinger, R.G. Carlini, E. Rojas Bone disease after renal transplantation Transplant Proc 31 1999 3033 3034
81. M.C. Monier-Faugere, H. Mawad, Q. Qi High prevalence of low bone turnover and occurrence of osteomalacia after kidney transplantation J Am Soc Nephrol 11 2000 1093 1099
82. C.R. Parker, P.J. Blackwell, A.J. Freemont Biochemical measurements in the prediction of histologic subtype of renal transplant bone disease in women Am J Kidney Dis 40 2002 385 396
83. E. Rojas, R.G. Carlini, P. Clesca The pathogenesis of osteodystrophy after renal transplantation as detected by early alterations in bone remodeling Kidney Int 63 2003 1915 1923
84. M.R. Rubin, J.P. Bilezikian Clinical review 151: The role of parathyroid hormone in the pathogenesis of glucocorticoid-induced osteoporosis: A re-examination of the evidence J Clin Endocrinol Metab 87 2002 4033 4041
85. S. Epstein Post-transplantation bone disease The role of immunosuppressive agents and the skeleton J Bone Miner Res 11 1996 1 7
86. P.J. Stewart, P.H. Stern Cyclosporines Correlation of immunosuppressive activity and inhibition of bone resorption Calcif Tissue Int 45 1989 222 226
87. P.J. Stewart, P.H. Stern Interaction of cyclosporine A and calcitonin on bone resorption in vitro Horm Metab Res 21 1989 194 197
88. A.M. Cuerto-Manzano, S. Konel, V. Crowley Bone histopathology and densitometry comparison between Cyclosporine A monotherapy and prednisolone plus azathioprine dual immunosuppression in renal transplant recipients Transplantation 75 2003 2053 2058
89. M.A. Josephson, L.P. Schumm, M.Y. Chiu Calcium and calcitriol prophylaxis against post-transplant bone loss Transplantation 78 2004 1233 1236
90. A.R. Bowman, D.A. Sass, I.R. Dissanayake The role of testosterone in cyclosporine-induced osteopenia J Bone Miner Res 12 1997 607 615
91. S. Epstein, I.R. Dissanayake, G.R. Goodman Effect of the interaction of parathyroid hormone and cyclosporine a on bone mineral metabolism in the rat Calcif Tissue Int 68 2001 240 247
92. E.M. Awumey, B.S. Moonga, B.R. Sodam Molecular and functional evidence for calcineurin-A alpha and beta isoforms in the osteoclast Novel insights into cyclosporine A action on bone resorption Biochem Biophys Res Commun 254 1999 248 252
93. F.J. Buchinsky, Y. Ma, G.N. Mann T lymphocytes play a critical role in the development of cyclosporine A-induced osteopenia Endocrinology 137 1996 2278 2285
94. C. Ponticelli, A. Aroldi Osteoporosis after organ transplantation Lancet 357 2001 1623
95. W. Grotz, A. Mundinger, B. Gugel Missing impact of cyclosporine on osteoporosis in renal transplant recipients Transplant Proc 26 1994 2652 2653
96. S. Kirino, J. Fukunaga, S. Ikegami Regulation of bone metabolism in immunosuppresant (FK 506)- treated rats J Bone Miner Metab 22 2004 554 560
97. A. Monegal, M. Navasa, N. Guanabens Bone mass and mineral metabolism in liver transplant patients treated with FK506 or cyclosporine A Calcif Tissue Int 68 2001 83 86
98. P. Sambrook Alfacalcidol and calcitriol in the prevention of bone loss after organ transplantation Calcif Tissue Int 65 1999 341 343
99. K. Lippuner, B. Haller, J.P. Casez Effect of disodium monofluorophosphate, calcium and vitamin D supplementation on bone mineral density in patients chronically treated with glucocorticosteroids A prospective, randomized, double-blind study Miner Electrolyte Metab 22 1996 207 213
100. E. Meys, F. Terreaux-Duvert, T. Beaume-Six Bone loss after cardiac transplantation effects of calcium, calcidiol and monofluorophosphate Osteoporos Int 3 1993 322 329
101. I. Garcia-Delgado, S. Prieto, L. Gil-Fraguas Calcitonin, etidronate, and calcidiol treatment in bone loss after cardiac transplantation Calcif Tissue Int 60 1997 155 159
102. Y.F. Smets, J.W. de Fijter, J. Ringers Long term follow-up study on bone mineral density and fractures after simultaneous pancreas-kidney transplantation Kidney Int 66 2004 2070 2076
103. M. Coco, D. Glicklich, M.C. Faugere Prevention of bone loss in renal transplant recipients A prospective, randomized trial of intravenous pamidronate J Am Soc Nephrol 14 2003 2669 2676
104. D. Kovac, J. Lindic, A. Kandus Prevention of bone loss in kidney graft recipients Transplant Proc 33 2001 1144 1145
105. S. Giannini, A. D'Angelo, G. Carraro Alendronate prevents further bone loss in renal transplant recipients J Bone Miner Res 16 2001 2111 2117
106. M. Haas, Z. Leko-Mohr, P. Roschger Zoledronic acid to prevent bone loss in the first 6 months after renal transplantation Kidney Int 63 2003 1130 1136
107. J.R. Jeffrey, W.D. Leslie, M.E. Karpinski Prevalence and treatment of decreased bone density in renal transplant recipients A randomized prospective trial of calcitriol versus alendronate Transplantation 76 2003 1498 1502
108. S. Lee, D. Glicklich, M. Coco Pamidronate used to attenuate post-renal transplant bone loss is not associated with renal dysfunction Nephrol Dial Transplant 19 2004 2870 2873
109. A.E. Kruse, U. Eisenberger, F.J. Frey The calcimimetic cinacalcet normalizes serum calcium in renal transplant patients with persistent hyperparathyroidism Nephrol Dial Transplant 20 2005 1311 1314
110. I. Tang, M.A. Josephson, N. Kopyt Cinacalcet in post-transplant hyperparathyroidism J Am Soc Nephrol 16 2005 500A
111. A.L. Serra, A.A. Schwarz, F.H. Wick Successful treatment of hypercalcemia with cinacalcet in renal transplant recipients with persistent hyperparathyroidism Nephrol Dial Transplant 20 2005 1315 1319