Potencies of topical glucocorticoids to mediate genomic and nongenomic effects on human peripheral blood mononuclear cells

Biochemical Pharmacology

Volumn 71, Issue 4, 2006, Pages 530-539

  Naumann, Lydia ^a   Feist, Eugen ^a   Straub, Rainer H ^b   Burmester, Gerd Rüdiger ^a   Buttgereit, Frank ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b UNIVERSITY HOSPITAL REGENSBURG   (Germany)

Author keywords

Apoptosis; Energy metabolism; Genomic and nongenomic glucocorticoid effects; Human peripheral blood mononuclear cells; IL 6; Systemic and topical glucocorticoids

Indexed keywords

BECLOMETASONE; CLOBETASOL; DEXAMETHASONE; GLUCOCORTICOID; INTERLEUKIN 6;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; ELECTRODE; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GENOMICS; HUMAN; HUMAN CELL; OXYGEN CONSUMPTION; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL;

ANTI-INFLAMMATORY AGENTS; APOPTOSIS; BECLOMETHASONE; CLOBETASOL; CONCANAVALIN A; DEXAMETHASONE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GLUCOCORTICOIDS; HUMANS; INTERLEUKIN-6; JURKAT CELLS; LEUKOCYTES, MONONUCLEAR; OXYGEN CONSUMPTION; PHYTOHEMAGGLUTININS;

EID: 30444450282     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2005.10.045     Document Type: Article

References (43)

1. F. Buttgereit, R.H. Straub, M. Wehling, and G.R. Burmester Glucocorticoids in the treatment of rheumatic diseases. An update on mechanisms of action Arthritis Rheum 50 11 2004 3408 3417
2. F. Buttgereit, M.D. Brand, and G.R. Burmester Equivalent dose and relative drug potencies for non-genomic glucocorticoid effects: a novel glucocorticoid hierarchy Biochem Pharmacol 58 1999 363 368
3. P.J. Barnes Anti-inflammatory actions of glucocorticoids: molecular mechanisms Clin Sci (Lond) 94 6 1998 557 572
4. E. Solito, A. Mulla, J.F. Morris, H.C. Christian, R.J. Flower, and J.C. Buckingham Dexamethasone induces rapid serine-phosphorylation and membrane translocation of annexin 1 in a human folliculostellate cell line via a novel non-genomic mechanism involving the glucocorticoid receptor, protein kinase C, phosphatidylinositol 3-kinase, and mitogen-activated protein kinase Endocrinology 144 4 2003 1164 1174
5. J.D. Croxtall, Q. Chudhury, and R.J. Flowers Glucocorticoids act within minutes to inhibit recruitment of signalling factors to activated EGF receptors through a receptor dependent, transcription independent mechanism Br J Pharm 130 2 2000 289 298
6. S. Sanden, R. Tripmacher, R. Weltrich, W. Rohde, F. Hiepe, and G.R. Burmester Glucocorticoid dose dependent downregulation of glucocorticoid receptors in patients with rheumatic diseases J Rheumatol 27 5 2000 1265 1270
7. T. Berki, A. Tavakoli, K.K. Nagy, G. Nagy, and P. Nemeth Alterations of glucocorticoid receptor expression during glucocorticoid hormone therapy in renal transplant patients Transpl Int 15 2-3 2002 132 138
8. B. Gametchu Glucocorticoid receptor-like antigen in lymphoma cell membranes: correlation to cell lysis Science 236 4800 1987 456 461
9. B. Bartholome, C.M. Spies, T. Gaber, S. Schuchmann, T. Berki, and D. Kunkel Membrane glucocorticoid receptors (mGCR) are expressed in normal human peripheral blood mononuclear cells and up-regulated after in vitro stimulation and in patients with rheumatoid arthritis FASEB J 18 1 2004 70 80
10. + ions into Con A stimulated thymocytes J Biochem 326 1997 329 332
11. F. Buttgereit, M.D. Brand, and M. Müller Effects of methylprednisolone on the energy metabolism of quiescent and Con A-stimulated thymocytes of rats Biosci Rep 13 1993 41 52
12. D. Schmid, G.R. Burmester, R. Tripmacher, A. Kuhnke, and F. Buttgereit Bioenergetics of human peripheral blood mononuclear cell metabolism in quiescent, activated and glucocorticoid-treated states Biosci Rep 20 2000 289 302
13. F. Buttgereit, and M.D. Brand A hierarchy of ATP-consuming processes in mammalian cells J Biochem 312 1995 163 167
14. D.F. Rolfe, and G.C. Brown Cellular energy utilization and molecular origin of standard metabolic rate in mammals Physiol Rev 77 3 1997 731 758
15. M. Muller, W. Siems, F. Buttgereit, R. Dumdey, and S.M. Rapoport Quantification of ATP-producing and consuming processes of Ehrlich ascites tumour cells Eur J Biochem 161 3 1986 701 705
16. S. Navarro, N. Debili, J.F. Bernaudin, W. Vainchenker, and J. Doly Regulation of the expression of IL-6 in human monocytes J Immunol 142 12 1989 4339 4345
17. F. Buttgereit, A. Grant, M. Müller, and M.D. Brand The effects of methylprednisolone on oxidative phosphorylation in Con A-stimulated thymocytes: top down elasticity analysis and control analysis Eur J Biochem 223 1994 513 519
18. A. Kuhnke, G.R. Burmester, S. Krauss, and F. Buttgereit Bioenergetics of immune cells to assess rheumatic disease activity and efficacy of glucocorticoid treatment Ann Rheum Dis 62 2 2003 133 139
19. J.D. Croxtall, P.T.W. van Hal, Q. Choudhury, D.W. Gilroy, and R.J. Flower Different glucocorticoids vary in their genomic and non-genomic mechanism of action in A549 cells Br J Pharmacol 135 2 2002 511 519
20. C.E. Griffiths Keeping psoriasis under wraps J Dermatolog Treat 12 3 2001 133
21. R. Pfister, and G. Menz Glucocorticosteroid therapy in bronchial asthma Pneumologie 49 5 1995 293 305
22. V.L. Cohan, B.J. Undem, C.C. Fox, N.F. Adkinson Jr., L.M. Lichtenstein, and R.P. Schleimer Dexamethasone does not inhibit the release of mediators from human mast cells residing in airway, intestine, or skin Am Rev Respir Dis 140 4 1989 951 954
23. F. Buttgereit, I. Brink, B. Thiele, G.R. Burmester, F. Hiepe, and E.D. Hall Effects of methylprednisolone and 21-aminosteroids on mitogen-induced interleukin-6 and tumor necrosis factor-alpha production in human peripheral blood mononuclear cells J Pharmacol Exp Ther 275 2 1995 850 853
24. R. Gold, F. Buttgereit, and K.V. Toyka Mechanism of action of glucocorticosteroid hormones: possible implications for therapy of neuroimmunological disorders J Neuroimmunol 117 1-2 2001 1 8
25. M. Ponec, J. Kempenaar, B. Shroot, and J.C. Caron Glucocorticoids: binding affinity and lipophilicity J Pharm Sci 75 10 1986 973 975
26. S.B. Koukouritaki, A.N. Margioris, A. Gravanis, R. Hartig, and C. Stournaras Dexamethasone induces rapid actin assembly in human endometrial cells without affecting its synthesis J Cell Biochem 65 4 1997 492 500
27. I.M. Adcock, and G. Caramori Cross-talk between pro-inflammatory transcription factors and glucocorticoids Immunol Cell Biol 79 4 2001 376 384
28. C. Seeto, H. Namkung-Matthai, S. Jayram, K. Foe, and K.F. Brown Differential potency of beclomethasone esters in-vitro on human T-lymphocyte cytokine production and osteoblast activity J Pharm Pharmacol 52 2000 417 423
29. M. Pörtner, H. Möllmann, and P. Rohdewald Glucocorticoid receptors in human synovial tissue and relative receptor affinities of glucocorticoid-21-esters Pharm Res 5 1988 623 627
30. S. Hammer, I. Spika, W. Sippl, G. Jessen, B. Kleuser, and H.D. Höltje Glucocorticoid receptor interactions with glucocorticoids: evaluation by molecular modeling and functional analysis of glucocorticoid receptor mutants Steroids 68 2003 329 339
31. S.M. Hulkko, H. Wakui, and J. Zilliacus The pro-apoptotic protein death-associated protein 3 (DAP3) interacts with the glucocorticoid receptor and affects the receptor function Biochem J 349 Pt 3 2000 885 893
32. H.M. Reichardt, J.P. Tuckermann, A. Bauer, and G. Schutz Molecular genetic dissection of glucocorticoid receptor function in vivo Z Rheumatol 59 Suppl. 2:II 2000 1 5
33. C.W. Distelhorst Recent insights into the mechanism of glucocorticosteroid-induced apoptosis Cell Death Diff 9 2002 6 19
34. J. Schmidt, R. Gold, L. Schonrock, U.K. Zettl, H.P. Hartung, and K.V. Toyka T cell apoptosis in situ in experimental autoimmune encephalomyelitis following methylprednisolone pulse therapy Brain 123 Pt 7 2000 1431 1441
35. H.M. Reichardt, K.H. Kaestner, J. Tuckermann, O. Kretz, O. Wessely, and R. Bock DNA binding of the glucocorticoid receptor is not essential for survival Cell 93 4 1998 531 541
36. M.C. Marchetti, B. Di Marco, G. Cifone, G. Migliorati, and C. Riccardi Dexamethasone-induced apoptosis of thymocytes: role of glucocorticoid receptor-associated Src kinase and caspase-8 activation Blood 101 2 2003 585 593
37. M.G. Cifone, G. Migliorati, R. Parroni, C. Marchetti, D. Millimaggi, and A. Santoni Dexamethasone-induced thymocyte apoptosis: apoptotic signal involves the sequential activation of phosphoinositide-specific phospholipase C, acidic sphingomyelinase, and caspases Blood 93 7 1999 2282 2296
38. R. Diem, M. Hobom, K. Maier, R. Weissert, M.K. Storch, and R. Meyer Methylprednisolone increases neuronal apoptosis during autoimmune CNS inflammation by inhibition of an endogenous neuroprotective pathway J Neurosci 23 18 2003 6993 7000
39. M. Leist Intracellular adenosine triphosphate (ATP) concentration: a switch in the decision between apoptosis and necrosis J Exp Med 185 1997 1481 1486
40. B. Dallaporta, P. Marchetti, M.A. de Pablo, C. Maisse, H.T. Duc, and D. Metivier Plasma membrane potential in thymocyte apoptosis J Immunol 162 11 1999 6534 6542
41. P. Marchetti, M. Castedo, S.A. Susin, N. Zamzami, T. Hirsch, and A. Macho Mitochondrial permeability transition is a central coordinating event of apoptosis J Exp Med 184 3 1996 1155 1160
42. B. Gametchu, C.S. Watson, and S. Wu Use of receptor antibodies to demonstrate membrane glucocorticoid receptor in cells from human leucemic patients FASEB 7 13 1993 1283 1292
43. F.N. Sackey, C.S. Watson, and B. Gametchu Cell cycle regulation of membrane glucocorticoid receptor in CCRF-CEM human ALL cells: correlation to apoptosis Am J Physiol 273 3 Pt 1 1997 E571 E583