Synthesis of new uracil-5-sulfonamide derivatives and immuno-stimulatory effect of a chemically modified hemolymph of Biomphalaria alexandrina on Schistosoma mansoni infected mice

Archives of Pharmacal Research

Volumn 26, Issue 5, 2003, Pages 358-366

  Fathalla, O A ^a   Haiba, M E ^a   Maghraby, A S ^a  

^a NATIONAL RESEARCH CENTRE   (Egypt)

Author keywords

Biomphalaria alexandrina; Haemolymph; Immunofluorescence technique; Schistosoma mansoni; Uracil 5 sulphonamide derivatives

Indexed keywords

EID: 30444440284     PISSN: 02536269     EISSN: 02536269     Source Type: Journal    
DOI: 10.1007/BF02976692     Document Type: Article

References (33)

1. Abdel-Hamid A. Z. and Fathalla O. A., Effect of Some uracil derivatives on mice bearing Ehlish Ascites Carcinoma. Egypt J. Pharm. Sci., 34(1-3), 67-80 (1993).
2. Abdel-Hamid, A. Z. and Rizk, M., High Pressure Liquid Chromatographic Analysis of DNA from Different Snail Species, Target and Non-Target to Schistosoma Infection, Egypt J. Bilh., 19, 59-73 (1997).
3. Abbady, M. A., Ezbawy, S. R., Radwan, Sh. M., Bayoumy, B. E., and Khalaf, A. A., Synthesis and biological activity of some New 4-(2-pyrzoline-3-yl)-, 4-92-Isoxazlin-4-yl) and 4-(1, 2, 5, 6-tetrahydro-2-thiopyrimidine-4-yl)- diarylsulphides and diaryl sulphones. Egypt J. Pharm. Sci., 27, 43-56 (1986).
4. Afifi, A., Contribution to the chemical carcinogenesis in xenopus, Ph.D. Thesis, UCL, Louvain ha Neuve, Belgium, pp. 90-91 (1986).
5. Argiro, L, Doerig, C, Liabeuf, S, Bourgois, A, and Romette, J. L., Production of Sm37-GAPDH, a major therapeutical target in human Schistosomiasis. Biotechnol-Bioeng., 68(2), 136-141 (2000).
6. Beigquist, N. R and Collel, D. G., Schistosomasis Vaccine; Research to development, Parasitology Today 14 pp. 99-104 (1998).
7. Bradford, M., Arapid and sensitive method for the quantitation of microgram quantities of protein utilizing the prenciples of protein_dye binding. Annals. Biochem., 72, 248-254 (1976).
8. Cioli, D., Chemotherapy of Schistosomiasis : An update. Parasitology Today, 14(10), 418-421 (1998).
9. Cioli, D, Pica-Mattoccia, L, and Archer, S., Anti-Schistosomal drugs : past, present and future?. Pharmacal. Ther., 68, 35-85 (1995).
10. Dean, D. A., A review Schistosoma and related genera : aquired resistance in mice. Exp. Parasitol., 55, 1-104 (1983).
11. Dean, D. A., Murrel, K. D., Shoutals, X. U., and Mangold, B. L., Immunization of mice with ultra-violet irradiated S.mansoni cerriae: Are-evaulation. Am. J. Trop. Med. Hyg., 790-793 (1983).
12. Dissous, C., Jrzych, J. M., and Capron, A., S. mansoni shares a protective oligosaccharid epitope with fresh water and marine snails. Nature, 323, 443-445 (1986).
13. Dissous. C., Torpier, G., Duvaux-Miret, O., and Capron, A., Structural homology of tropomysin from human trematde S. mansoni and its intermediate host. B. glabrata. Mol. Biochem. Parasitol., 43(2), 245-55 (1990).
14. Dodin, A., Essais de protection de la souris contre S. mansoni. Recherche d'antigens speifiques. Arch. Inst. Pasteur de Madagascar, 35, 195-197 (1966).
15. Duvall, R. H. and Dewitt, W. B, An improved perfusion technique for recovering odult Schistosomomes from laboratory animals. Am. J. Trop. Med. Hyg., 16, 483-486 (1967).
16. Ebeid, M. Y., Kamel, M. M., Nofal, Z. M., Gadalla, K. Z., and Abdou, W. A. M., Synthesis of some new- p-cinnamoylamino)-pyrimidines and other related products of possible Antischistosomal activity. Egypt J. Pharm. Sci., 32(1-2), 381-387 (1991).
17. Ebeid, M. Y., Fathalla, O. A., El-Zahar, M. I., Kamel, M. M., Abdou, W. A. M., and Anwar, M. M., New Tetralyl Thiazoles-The Anti-HIV and Anticancer screening of 3-[4-[6-(1, 2, 3, 4-Tetrahydronaphthyl)-Thiazol-2-yl-2-(P- chlorophenyl)-Thiazoidine-4-one. Bull. Fac. Pharm. Cairo Univ., 34(2), 125-135 (1996).
18. EL-Hamshary, A. S., EL-Fakarany, A. F., EL-Tahawy, E. A., EL-Fouly, M. M., and EL-Hawary, A. M., Immunological effects of NHN Vaccine, a chemically modified Biom-phlalaria alexandrina snails antige. Egypt J. Med. Sci., 17(2), 637-651 (1996).
19. Fallon, P. G, Smith, P, Niccholls, T, Modha, J., and Doenhoff, M, Praziquantal induced exposure of S. mansoni alkaline phosphatase : drug-antibody Synergy which acts preferentially against female worms. Imm., 16, 529 35 (1994).
20. Fathalla, O. A., Synthesis of some 1, 3-dimethyluracil-5-Sulphonamide- p-phenyl Derivatives with expected Biological Activity. Al-Azhar Bull. Sci., 3(2)(Dec.), 713-726 (1992).
21. Fathala, O. A. and Zaki, M. E. A., Studies on activated nitriles : Synthesis of new 3-cyano-2-(p-antipyrylamino)-pyrazolo [1,5a]pyimidines and pyrazolo [1, 5-a] triazines. Indian J. Chem., 37B, 484-490 (1998).
22. Fathalla, O. A., Synthesis of New Pyrazolo [1,5-a] Pyrimidine Derivatives Using 5-Aminouracil and Ketene Dithio Acital With expected Biological Activity. Arch. Pharm. Res., 22(6), 571-574 (1999).
23. Fathalla, O. A, Gad, H. S. M, and Maghraby, A. S., Synthesis of Some New Uracil-5-Sulphonamide- p-phenyl Derivatives and Their Effect on Biomphalaria alexandrina Snail, s nucleoproteins. Arch. Pharm. Res., 23(2), 128-138 (2000).
24. Grzych, J. M, Dissous, C, Capron, M., Torres, S., Tampert, P. H., and Capron, A., Schistosoma mansoni shares with keyhole limpet hemocyanine a protective carbohydrate epitope. J. Exp. Med., 65, 865-878 (1987).
25. Kamel, M. M., Gadalla, K. Z., Elhamouly, W.S., and Elwessimi, M. T., Synthesis of some new 4-cinnamoylanilinoquiolines of possible biological activity. Z. Naturforsch, 40b, 661-666 (1985).
26. Kamel, M. M, Fahmy, H. H., and Abdou, W. A. M., Synthesis of Some substituted Titraline of bossible Molluscicidal Activity, Egypt J. Chem., 39(6), 573-580 (1996).
27. Hasaneen, H., Kamel, M. M, El-Zahar, M. L., and Eman, M., Synthesis of p-Cinnamoyl anilino Lepidines and Other Related Products of Potential Antimicrobial Activity. Egypt J. Chem., 38(2), 241-248 (1995).
28. Nash, T. E, Prescott, B., and Neva, F. A., The characteristics of a circulating antigen in Schistosomiasis. J. Immunol., 112, 1500 (1974).
29. Oliver, L. and Stirewalt, M. A., An effective method for the exposure of mice to cecarrriae of Schistosoma mansoni. J. Parasitology, 38, 19 (1952).
30. Salama, M. A., Sayed, G. H., Abdou, W. A. M., Maghraby, A. S., and Flefil, E. M., Synthesis and Immunological studies of some new substituted tetrahydronaphthaline on Biomphalaria alexandrina snails. Bull. Pharm. Cairo Univ., 35(1), 65-71 (1996).
31. Schwick, H. G., Hungerer, K. D., and Zwisler, O., In: New developments with human and verterinary vaccines, Ed. Mizrahi, A., Hertman, I., Klingberg, M.A. and Kohn, A., New York, pp.229-240 (1980).
32. Shalaby, A.M, Fathalla, O. A, Kassem, E. M. M., and Zaki, M. E. A., Synthesis of New 5- N-Pyrazololyl amino acids, pyrazolopyrimidines and pyrazolopyridines derivatives. Acta Chim. Slov., 47, 187-203 (2000).
33. Verity, C. K., McManus, D. P., and Brindley, P. J., Vaccine efficacy of recombinant cathepsin D aspartic protease from Schistosoma japonicum. Parasite Immunol., 23(3), 153-62 (2001).