Cytotoxic and apoptotic activites of echinomycin derivative (echinomycin-7) on P388 murine leukemia cells

Journal of Biochemistry and Molecular Biology

Volumn 31, Issue 6, 1998, Pages 560-564

  Jeon, Hyang ^a   Kim, Sung Su ^a   Kim, Yoon Suk ^a   Park, Yil Sung ^b   Kim, Yong Hae ^b   Choi, Sun Ju ^c   Kim, Soo Kie ^c   Kim, Tae Ue ^a  

^a Yonsei University Wonju   (South Korea)

^b Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

^c Yonsei University Wonju College of Medicine   (South Korea)

Author keywords

Antitumor activity; Cytotoxicity; DNA fragmentation; Echinomycin derivative; MAP kinase

Indexed keywords

EID: 3042882517     PISSN: 12258687     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Barry, M. A., Behnke, C. A. and Eastman, A. (1990) Activation of progrommed cell death (apoptosis) by cisplatin, other anticancer drugs toxins and hyperthermia. Biochem. Pharmacol. 40, 2353-2362.
2. Blagosklonny, M. V., Schulte, T., Nguyen, P., Trepel, T. and Neckers, L. M. (1996) Taxol-induced apoptosis and phosphorylation of Bcl-2 protein involved c-Raf-1 and represent a novel c-Raf-1 signal transduction pathway. Cancer Res. 56, 1851-1854.
3. Boulton, T. G., Nye, S. H., Robbins, D. J., Ip, N. Y., Radziejewska, E. and Morgenbesser, S. D. (1991) ERKs: A family of protein serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF. Cell 65, 663-675.
4. Chen, R. H., Sharnecki, C. and Blenis. J. (1992) Nuclear localization and regulation of erk- or rsk-encoded protein kinases. Mol. Cell Biol. 12, 915-927.
5. Cortes, D., Reuther, G. and Pendergast, A. M. (1997) The Bcr-Abl tyrosine kinase activates mitogenic signaling pathways and stimulates G1-to-S phase transition in hematopoietic cells. Oncogene 15, 2333-2342.
6. Coso, O. A., Chiariello, M., Yu, J. C., Teramoto, H., Crespo, P., Xu, N., Miki, T. and Gutkind, S. (1995) The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway. Cell 81, 1137-1146.
7. Davis, R. J. (1993) The mitogen-activated protein kinase signal transduction pathway. J. Biol. Chem. 268, 14553-14556.
8. Dyfed, L. E., Michael T. and Caroline D. (1994) Differential sensitivity to the induction of apoptosis by cisplatin in proliferating and quiescent immature rat thymocytes is independent of the levels of drug. Cancer Res. 54, 1596-1603.
9. Gardner, A. M. and Johnson, G. L. (1996) Fibroblast growth factor-2 suppression of tumor necrosis factor α-mediated apoptosis requires ras and the activation of mitogen-activated protein kinase. J. Biol. Chem. 273, 4928-4936.
10. Gorczyca, W., Gong, J., Ardelt, B., Traganos, F. and Darzynkiewicz, Z. (1993) The cell cycle related differences in susceptibility of HL-60 cells to apoptosis induced by various antitumor agents. Cancer Res. 53, 3186-3192.
11. 2: role in cell survival following oxidant injury. J. Biol. Chem. 271, 4138-4142.
12. Kaufmann S. H. (1989) Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs; a cautionary tale. Cancer Res. 49, 5870-5878.
13. Kaufmann S. H., Desnoyers, S., Ottaviano, Y., Davidson, N. E. and Poirier, G. G. (1993) Specific proteolytic cleavage of poly(ADP-ribose)polymerase: An early marker of chemotherapy-induced apoptosis. Cancer Res. 53, 3976-3985.
14. Kim, T. U., Yang, S. H. and Kim, S. K. (1996) Cytotoxic and apoptotic effects of echinomycin on murine leukemia cells. J. Biochem. Mol. Biol. (formerly Korean Biochem. J.) 29. 486-492.
15. Lee, Y. and Lee, Y.I. (1996) Effects of non-cytotoxic concentration of anticancer drugs on doxorubicin cytotoxicity in human breast cancer cell lines. J. Biochem. Mol. Biol. (formerly Korean Biochem. J.) 29, 314-320.
16. McConkey, D. J., Orrenius, S. and Jondal, M. (1996) Cellular signaling in programmed cell death (apoptosis). Immunol. Today. 11, 120-121.
17. Molnar, A., Theodoras, A. M., Zon, L. I. and Kyriakis, J. M. (1997) Cdc42Hs, but not Rac1, inhibits serum-stimulated cell cycle progression at G1-S through a mechanism requiring p38/ RK. J. Biol. Chem. 272, 13229-13235.
18. Muss, H. B., Blessing, J. A., Baker, V. V., Barnhill, D. R. and Greenwald, E. S. (1990) Echinomycin (NSC 526417) in advanced ovarian cancer. Am. J. Clin. Oncol. 13, 299-301.
19. Nam, S. M., Cho, J. E., Son, B. S. and Park, Y. S. (1998) Convenient preparation of tumor-specific immunoliposomes containing doxorubicin. J. Biochem. Mol. Biol. (formerly Korean Biochem. J.) 31, 95-100.
20. Park, Y. S., Kim Y. H., Kim, S. K. and Choi, S. J. (1998) A new antitumor agent: methyl sulfonium perchlorate of echinomycin. Bioorganic Medicinal Chem. Lett. 8, 731-735.
21. Saleem, A., Datta, R., Yuan, Z. M., Kharbanda, S. and Kufe, D. (1995) Involvement of stress-activated protein kinase in the cellular response to 1- β-D-arabinofuranosylcytosine and other DNA-damaging agents. Cell Growth Differ. 6, 1651-1658.
22. Sorecson, C. M., Barry, M. A. and Eastman, A. (1990) Analysis of events associated with cell cycle arrest at G2 phase and cell death induced by cisplatin. J. Natl. Cancer Inst. 82, 749-755.
23. Walker, P. R., Smith, C., Youdale, T., Leblance, J., Whitfield, J. and Sparano, J. A. (1991) Topoisomerase II-reactive chemotherapeutic drugs induce apoptosis in thymocytes. Cancer Res. 51, 1078-1085.
24. Wadler, S., Tenteromano, L., Cazenave, L., Greenwald, E. S., Rozenblit, A., Kaleya, R. and Wiemik, P. H. (1994) Phase II trial of echinomycin in patients with advanced or recurrent colorectal cancer. Cancer Chemother. Pharm. 34, 266-269.
25. Wang, T. H., Wang, H. S. and Ichijo, H. (1998) Microtubule-interfering agents activate c-Jun N-terminal kinase/stress-activated protein kinase through both ras and apoptosis signal-regulating kinase pathways. J. Biol. Chem. 273, 4928-4936.
26. Waring, M. J. (1992) Echinomycin. Path. Biol. 10, 1022-1034.
27. Waring, M. J. and Wakelin, I. P. G. (1974) Echinomycin: a bifunctional intercalating antibiotic. Nature. 252, 653-657.
28. Yu, R., Shtil, A. A., Tan, T. H., Roninson, I. B. and Kong, A. T. (1996) Adriamycin activates c-Jun N-terminal kinase in human leukemia cells: a relevance to apoptosis. Cancer Lett. 107, 73-81.