Blood perfusion in a murine fibrosarcoma tumor model after direct current electrotherapy: A study with 86Rb extraction technique

Electromagnetic Biology and Medicine

Volumn 17, Issue 2, 1998, Pages 273-282

  Jarm, T ^a   Cemazar M ^b   Sersa G ^b   Miklavcic D ^a  

^a UNIVERSITY OF LJUBLJANA   (Slovenia)

^b INSTITUTE OF ONCOLOGY   (Slovenia)

Author keywords

86RbCl extraction technique; Blood perfusion; Electrotherapy; Experimental tumor models

Indexed keywords

EID: 3042879467     PISSN: 15368378     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Humphrey, C.E., and Seal, E.H.: Biophysical approach towards tumor regression in mice, Science 130, 388-390, 1959.
2. David, S.L., Absolom, D.R., Smith, C.R., Gams, J., and Herbert, M.A.: Effect of low level direct current on in vivo tumor growth in hamsters, Cancer Res. 45, 5626-5631, 1985.
3. Marino, A.A., Morris, D., and Arnold, T.: Electrical treatment of Lewis lung carcinoma in mice, J. Surg. Res. 41, 198-201, 1986.
4. Heiberg, E., Nalesnik, W.J., and Janney, C.: Effects of varying potential and electrolytic dosage in direct current treatment of tumors, Acta Radiol. 32, 174-177, 1991.
5. Griffin, D.T., Dodd, N.J.F., Moore, J.V., Pullan, B.R., and Taylor, T.V.: The effects of low-level direct current therapy on a preclinical mammary carcinoma: tumour regression and systemic biochemical sequelae, Br. J. Cancer 69, 875-878, 1994.
6. Xin, Y.-L.: Advances in the treatment of malignant tumours by electrochemical therapy, Eur. J. Surg. (Suppl.) 574, 31-36, 1994.
7. Plesničar, A., Serša, G., Vodovnik, L., Jančar, J., Zaletel-Kregelj, L., and Plesničar, S.: Electric treatment of human melanoma skin lesions with low level direct electric current: an assessment of clinical experience following a preliminary study in five patients, Eur. J. Surg. (Suppl.) 574, 45-49, 1994.
8. Serša, G., Miklavčič, D., Batista, U., Novakovič, S., Bobanovič, F., and Vodovnik, L.: Anti-tumor effect of electrotherapy alone or in combination with interleukin-2 in mice with sarcoma and melanoma tumors, Anti-Cancer Drugs 3, 253-260, 1992.
9. Serša, G., Novakovic, S., and Miklavčič, D.: Potentiation of bleomycin antitumor effectiveness by electrotherapy, Cancer Lett. 69, 81-84, 1993.
10. Serša, G., Golouh, R., and Miklavčič, D.: Anti-tumor effect of tumor necrosis factor combined with electrotherapy on mouse sarcoma, Anti-Cancer Drugs 5, 69-74, 1994.
11. Miklavčič, D., Serša, G., Kryžanowski, M., Novakovič, S., Bobanovič, F., Golouh, R., and Vodovnik, L.: Tumor treatment by direct electric current - tumor temperature and pH, electrode material and configuration, Bioelectrochem. Bioenerg. 30, 209-220, 1993.
12. Miklavčič, D., Fajgelj, A., and Serša, G.: Tumor treatment by direct electric current: electrode material deposition, Bioelectrochem. Bioenerg. 35, 93-97, 1994.
13. Vaupel, P.: Oxygen supply to malignant tumors, in Tumor Blood Circulation: Angiogenesis, Vascular Morphology and Blood Flow of Experimental and Human Tumors, Peterson, H.-I., ed., CRC Press, Inc., Boca Raton, FL, 143-168, 1979.
14. Vaupel, P.: Hypoxia in neoplastic tissue, Microvasc. Res. 13, 399-408, 1977.
15. Jain, R.K.: Determinants of tumor blood flow: a review, Cancer Res. 48, 2641-2658, 1988.
16. Zanelli, G.D., and Fowler, J.F.: The measurement of blood perfusion in experimental tumors by uptake of 86Rb, Cancer Res. 34, 1451-1456, 1974.
17. Sapirstein, L.A.: Regional blood flow by fractional distribution of indicators, Am. J. Physiol. 193, 161-168, 1958.
18. Miklavčič, D., Jarm, T., Karba, R., and Serša, G.: Mathematical modelling of tumor growth in mice following electrotherapy and bleomycin treatment, Math. Comput. Simulat. 39, 597-602, 1995.
19. Jarm, T., Wickramasinghe, Y.A.B.D., Deakin, M., Čemažar, M., Miklavčič, D., Serša, G., Elder, J., Rolfe, P., and Vodovnik, L.: Blood perfusion and oxygenation of tumours following electrotherapy - a study by means of near infrared spectroscopy and Patent Blue staining, in Proceedings of the 9th International Conference on Mechanics in Medicine and Biology, Ljubljana, Slovenia, 30 June-4 July 1996, 339-342.