Ivermectin in small animal dermatology. Part I. Pharmacology and toxicology

Compendium on Continuing Education for the Practicing Veterinarian

Volumn 20, Issue 2, 1998, Pages 193-200

  Paradis, Manon ^a,b  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

^b Amer Coll of Vet Dermatology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA; CANIS FAMILIARIS; DIROFILARIA IMMITIS; FELIS CATUS; MAMMALIA;

EID: 3042874885     PISSN: 01931903     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (57)

1. Campbell WC: Ivermectin: A review of efficacy and safety. J Vet Pharmacol 7:1-16, 1984.
2. Campbell WC: Ivermectin, an antiparasitic agent. Med Res Rev 13: 61-79, 1993.
3. Turner MJ: Mode of action of ivermectin, in Campbell WC (ed): Ivermectin and Abamectin. New York, Springer-Verlag, 1989, pp 73-88.
4. Paradis M: Ivermectin in small animal dermatology, in Kirk RW (ed): Current Veterinary Therapy. X. Small Anim Practice. Philadelphia, WB Saunders Co, 1989, pp 560-563.
5. Shoop WI, Mrozik H, Fisher MH: Structure and activity of avermectins and milbemycins in animal health. Vet Parasitol 59:139-156, 1995.
6. Soboslay PT, Dreweck CM, Hoffman WH, et al: Ivermectin-facilitated immunity in onchocerciasis. Reversal of lymphopenia, cellular anergy and deficient cytokine production after a single treatment. Clin Exp Immunol 89:407-413, 1992.
7. Blakley BR, Rousseaux CG: Effect of ivermectin on the immune response in mice. Am J Vet Res 52:593-595, 1991.
8. Frank LA, Kania SA: The effect of ivermectin on lymphocyte blastogenesis and T-cell subset ratios in healthy dogs. Vet Allerg Clin Immunol 5:27-30, 1997.
9. Scott DW, Miller WH Jr, Griffin CE: Muller and Kirk's Small Animal Dermatology. V. Philadelphia, WB Saunders Co, 1995, pp 417-432.
10. Moriello KA: Treatment of Sarcoptes and Cheyletiella infestations, in Kirk RW, Bonagura JD (eds): Kirk's Current Veterinary Therapy. XI. Small Animal Practice. Philadelphia, WB Saunders Co, 1992, pp 558-560.
11. Yazwinski TA, Pote L, Tilley W, et al: Efficacy of ivermectin against Sarcoptes scabiei and Otodectes cynotis infestations in dogs. Vet Med Small Anim Clin 76:1749-1751, 1981.
12. Scheldt VJ, Medleau L, Seward RL, Schwartzman RM: An evaluation of ivermectin in the treatment of sarcoptic mange in dogs. Am J Vet Res 5:1201-1204, 1984.
13. Miller WH Jr, de Jaham C, Scott DW, Cayatte SM: Treatment of canine scabies with milbemycin oxime. Can Vet J 37: 219-221, 1996.
14. Paradis M, de Jaham C, Page N: Topical (pour-on) ivermectin in the treatment of canine scabies. Can Vet J 38:379-382, 1997.
15. Bigler B, Waber S, Pfister K: Successful treatment of Notoedres cati infestation with ivermectin. Schweiz Arch Tierheilkd 126:365-367, 1984.
16. Chauve C, Reynauld MC: Traitement parentéral de l'otocariose du chat: Efficacité de l'ivermectine. Sc Vet Med Comp 86:189-192, 1984.
17. Franc M, Dorchies P, Soubeyroux H: Essai de traitement de l'otocariase du chat par les ivermectines. Rev Med Vet 136:683-686, 1985.
18. Jeneskog T, Falk K: The effect of local ivermectin treatment on ear mite infestation in a cat breeding colony. Scand J Lab Anim Sci 1:17-22, 1990.
19. Gram D, Payton AJ, Gerig TM, Bevier DE: Treating ear mites in cats: A comparison of subcutaneous and topical ivermectin. Vet Med 89:1122-1125, 1994.
20. de Jaham C, Paradis M: Topical (pour-on) ivermectin in the treatment of feline otocariasis. Proc World Cong Vet Dermatol 3:34, 1996.
21. Paradis M, Villeneuve A: Efficacy of ivermectin against Cheyletiella yasguri infestation in dogs. Can Vet J 29:633-635, 1988.
22. Paradis M, Scott DW, Villeneuve A: Efficacy of ivermectin against Cheyletiella blakei infestation in cats. JAAHA 26: 125-128, 1990.
23. Song MD: Using ivermectin to treat feline dermatoses caused by external parasites. Vet Med 86:498-502, 1991.
24. Medleau L: Using ivermectin to treat parasitic dermatoses in small animals. Vet Med 89:770-774, 1994.
25. Gram WD: Use of ivermectin in the treatment of ectoparasites, in August JR (ed): Consultation in Feline Internal Medicine. II. Philadelphia, WB Saunders Co, 1994, pp 215-218.
26. Scott DW, Walton DK: Experiences with the use of amitraz and ivermectin for the treatment of generalized demodicosis in dogs. JAAHA 21:535-541, 1985.
27. Garfield RA, Reedy LM: The use of oral milbemycin oxime (Interceptor®) in the treatment of chronic generalized demodicosis. Vet Dermatol 3:231-235, 1992.
28. Miller WH Jr, Scott DW, Wellington JR, Panic R: Clinical efficacy of milbemycin oxime in the treatment of generalized demodicosis in adult dogs. JAVMA 203:1426-1429, 1993.
29. Miller WH Jr, Scott DW, Cayatte SM, et al: Clinical efficacy of increased dosages of milbemycin oxime for treatment of generalized demodicosis in adult dogs. JAVMA 207:1581-1584, 1995.
30. Paradis M, Laperrière E: Efficacy of daily ivermectin treatment in a dog with amitraz-resistant generalized demodicosis. Vet Dermatol 3:85-88, 1992.
31. Ristic Z, Medleau L, Paradis M, White-Weithers NE: Efficacy of orally administered daily ivermectin in dogs with generalized demodicosis. JAVMA 207:1308-1310, 1995.
32. Medleau L, Ristic Z, McElveen DR: Daily ivermectin for treatment of generalized demodicosis in dogs. Vet Dermatol 7:209-212, 1996.
33. Guaguère E: Traitement de la démodécie généralisée du chien par l'ivermectine: A propos de 20 cas. Prat Méd Chir Anim Comp 31:33-40, 1996.
34. Fondati A: Efficacy of daily oral ivermectin in the treatment of 10 cases of generalized demodicosis in adult dogs. Vet Dermatol 7:99-104, 1996.
35. Paradis M, de Jaham C, Page N: Topical (pour-on) ivermectin in the treatment of chronic generalized demodicosis in dogs. Vet Dermatol, accepted for publication.
36. Mundel AC, Ihrke PJ: Ivermectin in the treatment of Pneumonyssus caninum. A case report. JAAHA 26:393-396, 1990.
37. Brandt RW: Pneumonyssus caninum (nasal mites) in four golden retrievers. Can Vet J 29:741, 1988.
38. Anderson DL, Roberson EL: Activity of ivermectin against canine intestinal helminths. Am J Vet Res 43:1681-1683, 1982.
39. Yazwinski TA, Tilley W, Greenway T: Efficacy of ivermectin in the treatment of artificially induced canine mixed gastrointestinal helminthiasis. Vet Med Small Anim Clin 77:225-226, 1982.
40. Blackburn BL, Hendrix CM, Lindsay DS, Vaughan JL: Anthelmintic efficacy of ivermectin in naturally parasitized cats. Am J Vet Res 48:670-672, 1987.
41. Soll MD, d'Assonville JA, Smith CJZ: Efficacy of topically applied ivermectin against sarcoptic mange (Sarcoptes scabiei var. bovis) of cattle. Parasitol Res 78:120-122, 1992.
42. Marley SE, Hall RD, Corwin RM: Ivermectin cattle pouron: Duration of a single late spring treatment against horn flies, Haematobia irritans (L) (Diptera: Muscidae) in Missouri, USA. Vet Parasitol 51:167-172, 1993.
43. Scott EW, Kinabo LD, McKellar QA: Pharmacokinetics of ivermectin after oral or percutaneous administration to adult milking goats. J Vet Pharmacol Ther 13:432-435, 1990.
44. Lo P-KA, Fink DW, Williams JB, Blodinger J: Pharmacokinetic studies of ivermectin: Effects of formulation. Vet Res Commun 9:251-268, 1985.
45. Fink DW, Porras AG: Pharmacokinetics of ivermectin in animals and humans, in Campbell WC (ed): Ivermectin and Abamectin. New York, Springer-Verlag, 1989, pp 113-130.
46. Clark JN, Pulliam JD, Alva R, Daurio CP: Safety of orally administered ivermectin in cats. Proc Am Heartworm Soc: 103-109, 1992.
47. Pulliam JD, Preston JM: Safety of ivermectin in target animals, in Campbell WC (ed): Ivermectin and Abamectin. New York, Springer-Verlag, 1989, pp 149-161.
48. Daurio CP, Gilman MR, Pulliam JD, Seward RL: Reproductive evaluation of male beagles and safety of ivermectin. Am J Vet Res 48:1755-1760, 1987.
49. Tudury EA, Lorenzoni OD: Efeitos adversos do ivermectin em tres gatinhos Siameses com sarna notedrica. Rev Centro Cien Rurais St Maria 17:275-281, 1987.
50. Lewis DT, Merchant SR, Neer TM: Ivermectin toxicosis in a kitten. JAVMA 205:584-586, 1994.
51. Lovel RA: Ivermectin and piperazine toxicosis in dogs and cats. Vet Clin North Am Small Anim Pract 20:453-468, 1990.
52. Sikarskie JG: The use of ivermectin in birds, reptiles, and small animals, in Kirk RW (ed): Current Veterinary Therapy. IX. Small Animal Practice. Philadelphia, WB Saunders Co, 1986, pp 743-745.
53. Golightly LK, Smolinske SS, Bennet ML, et al: Pharmaceutical excipients: Adverse effects associated with inactive ingredients in drug products. Med Toxicol 3:128-165, 1988.
54. Paul AJ, Tranquilli WJ, Steward RL, et al: Clinical observations in collies given ivermectin orally. Am J Vet Res 48:684-685, 1987.
55. Tranquilli WJ, Paul AJ, Seward RL: Ivermectin plasma concentrations in collies sensitive to ivermectin-induced toxicosis. Am J Vet Res 50:769-770, 1989.
56. Paul A, Tranquilli W: Ivermectin, in Kirk RW (ed): Current Veterinary Therapy. X. Small Animal Practice. Philadelphia, WB Saunders Co, 1989, pp 140-142.
57. Tranquilli WJ, Paul AJ, Seward RL, et al: Response to physostigmine administration in collie dogs exhibiting ivermectin toxicosis. J Vet Pharmacol Ther 10:96-100, 1987.