Effects of osmotic pressure on recombinant BHK cell growth and von willebrand factor (vWF) expression

Process Biochemistry

Volumn 39, Issue 11, 2004, Pages 1817-1823

  Yi, Xiaoping ^a   Sun, Xiangming ^a   Zhang, Yuanxing ^a  

^a EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Cell apoptosis; Cell culture; Cell cycle; Osmotic pressure; Recombinant BHK cell

Indexed keywords

AMINO ACIDS; BIOLOGICAL ORGANS; CELLS; OSMOSIS;

BATCH CULTURE; CELL GROWTH; PULSE CULTURE;

BIOCHEMISTRY;

BACTERIA (MICROORGANISMS); CRICETINAE;

EID: 3042842695     PISSN: 00329592     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.procbio.2003.09.006     Document Type: Article

References (12)

1. Ozturk S.S., Palsson B.O. Effect of medium osmolarity on hybridoma growth, metabolism, and antybody production. Biotechnol. Bioeng. 37:1991;989-993
2. Qyaas K., Eilingsen T.E., Dyrset N. Utilization of osmoprotective compounds by hybridoma cells exposed to hyperosmotic stress. Biotechnol. Bioeng. 43:1994;77-89
3. Oh S.K.W., Chua F.K.F., Choo A.B.H. Intracellular responses of productive hybridomas subjected to high osmotic pressure. Biotechnol. Bioeng. 46:1995;525-535
4. Cherlet M., Marc A. Hybridoma cell behaviour in continuous culture under hyperosmotic stress. Cytotechnology. 29:1999;71-84
5. Sun X., Zhang Y. Effects of lactate on growth, metabolism and EPO expression of recombinant CHO cells. Chin. J. Chem. Eng. 53:2002;1034-1039
6. Molid M. The theory of pressure effects on enzymes. Adv. Protein Chem. 34:1981;93-166
7. Nakashima K., Horikoshi K., Mizuno T. Effects of hydrostatic pressure on the synthesis of outer membrane proteins in E. coli. Biosci. Biotech. Biochem. 59:1995;130-132
8. Fiorino A., Frigo G., Cucchett E. Liquid chromatographic analysis of amino and imino acids in protein hydrolysates by post-column derivatization with o-phthalaldehyde and 3-mercaptopropionic acid. J. Chromatogr. 476:1989;83-92
9. Yancey P.H., Clark M.E., Hand S.C. Living with water stress: evolution of osmolyte systems. Science. 217:1982;1214-1222
10. Lin J., Takagi M., Qu Y. Enhanced monoclonal antibody production by gradual increase of osmotic pressure. Cytotechnology. 29:1999;27-33
11. 1 phase in continuous chemostat cultures of hybridoma cells. Biotechnol. Bioeng. 64:1999;174-186
12. Banik G.G., Todd P.W., Kompala D.S. Foreign protein expression from S-phase specific promoters in continuous cultures of recombinant CHO cells. Cytotechnology. 22:1996;179-184