The behaviour of ethyl 1-acetyl-4-aryl-5-cyano-3-methyl-1,4- dihydropyrano[2,3-c]pyrazol-6-ylimidoformate towards nucleophiles

Heterocyclic Communications

Volumn 10, Issue 1, 2004, Pages 97-102

  Zaki, M E A ^a   Morsy, E M ^a   Abdel Motti, F M ^a   Abdel Megeid, F M E ^a  

^a NATIONAL RESEARCH CENTRE   (Egypt)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIHYDRO (4 NITROPHENYL) 5 IMINOPYRAZOLO[4',3':5,6]PYRANO[2,3 D]PYRIMIDIN 6 AMINE; 1,4 DIHYDRO 11 (3 METHOXYPHENYL) 10 METHYL 2 (4 PYRIDYL)PYRAZOLO[4',3':5,6]PYRANO[2,3 E][1,2,4]TRIAZOLO[1,5 C]PYRIMIDINE; 1,4 DIHYDRO 3 METHYL 4 (4 NITROPHENYL)PYRAZOLO[4',3':5,6]PYRANO[2,3 D]PYRAMIDIN 5 AMINE; 1,4 DIHYDRO 3 METHYL 4 (4 NITROPHENYL)PYRAZOLO[4',3':5,6]PYRANO[2,3 D]PYRIMIDIN 5 YL 4 NITROBENZCARBALDEHYDE HYDRAZONE; 1,4 DIHYDRO 5 IMINO 3 METHYL 4 (4 NITROPHENYL)PYRAZOLO[4',3':5,6]PYRANO[2,3 D]PYRIMIDIN 6 (4 NITROBENZYLIDENE)AMINE; 1,4 DIHYDRO 5 IMINO 3 METHYL 4 (4 NITROPHENYL)PYRAZOLO[4',3':5,6]PYRANO[2,3 D]PYRIMIDIN 6 BENZYLIDENE AMINE; 2 DICHLOROMETHYL 8,11 DIHYDRO 10 METHYL 11 (4 NITROPHENYL)PYRAZOLO[4',3':5,6]PYRANO[2,3 E][1,2,4]TRIAZOLO[1,5 C]PYRIMIDINE; 8 ACETYL 8,11 DIHYDRO 11 (3 METHOXYPHENYL) 2,10 DIMETHYLPYRAZOLO[4',3':5,6]PYRANO[2,3 E][1,2,4]TRIAZOLO[1,5 C]PYRIMIDINE; 8 ACETYL 8,11 DIHYDRO 11 (4 NITROPHENYL) 2,10 DIMETHYLPYRAZOLO[4',3':5,6]PYRANO[2,3 E][1,2,4]TRIAZOLO[1,5 C]PYRIMIDINE; 8,11 DIHYDRO 10 METHYL 11 (3 METHOXYPHENYL) 2 TRICHLOROMETHYLPYRAZOLO[4',3':5,6]PYRANO[2,3,E][1,2,4]TRIAZOLO[1,5 C]PYRIMIDINE; 8,11 DIHYDRO 10 METHYL 11 (4 NITROPHENYL) 2 TRICHLOROMETHYLPYRAZOLO[4',3':5,6]PYRANO[2,3,E][1,2,4]TRIAZOLO[1,5 C]PYRIMIDINE; 8,11 DIHYDRO 10 METHYL 11 (4 NITROPHENYL)PYRAZOLO[4',3':5,6]PYRANO[2,3 E][1,2,4]TRIAZOLO[1,5 C]PYRIMIDIN 2 AMINE; 8,11 DIHYDRO 10 METHYL 2 PHENYL 11 (4 NITROPHENYL)PYRAZOLO[4',3':5,6]PYRANO[2,3,E][1,2,4]TRIAZOLO[1,5 C]PYRIMIDINE; 8,11 DIHYDRO 10 METHYL 2,11 (4 NITROPHENYL)PYRAZOLO[4',3':5,6]PYRANO[2,3,E][1,2,4]TRIAZOLO[1,5 C]PYRIMIDINE; 8,11 DIHYDRO 11 (3 METHOXYPHENYL) 10 METHYLPYRAZOLO[4',3':5,6]PYRANO[2,3 E][1,2,4]TRIAZOLO[1,5 C]PYRIMIDINE; 8,11 DIHYDRO 11 (4 NITROPHENYL) 10 METHYLPYRAZOLO[4',3':5,6]PYRANO[2,3 E][1,2,4]TRIAZOLO[1,5 C]PYRIMIDINE; 8,11 DIHYDRO 2 FURYL 10 METHYL 4 (4 NITROPHENYL)PYRAZOLO[4',3':5,6]PYRANO[2,3 E][1,2,4]TRIAZOLO[1,5 C]PYRIMIDINE; ALDEHYDE; AMMONIA; CARBOXYLIC ACID DERIVATIVE; ETHYL 1 ACETYL 5 CYANO 3 METHYL 4 (3 METHOXYPHENYL) 1,4 DIHYDROPYRANO[2,3 C]PYRAZOL 6 YLIMIDOFORMATE; ETHYL 1 ACETYL 5 CYANO 3 METHYL 4 (4 NITROPHENYL) 1,4 DIHYDROPYRANO[2,3 C]PYRAZOL 6 YLIMIDOFORMATE; HYDRAZINE; PYRAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; NUCLEAR MAGNETIC RESONANCE; POLYMERIZATION;

EID: 3042833611     PISSN: 07930283     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Diana, G. G.; Carabateas, P. M.; William, G. L.; Panicic, I.; Steinberg, B. A. J. Med. Chem. 1981, 24, 431.
2. Elmoghayar, M. R. H.; Ibrahim, M. K. A.; Elsakka, I.; Elghandour, A. H. H. Arch. Pharm. 1983, 316, 697.
3. Sugiura, S.; Ohno, S.; Wakayama, T. J. Pharm. Soc. Jpn. 1982, 97, 791.
4. Kuo, S. C.; Huang, L. J.; Nakamura, H. J. Med. Chem. 1984, 27, 539.
5. Chantegral, B.; Nadi, A.; Gelin, S. J. Heterocycl. Chem. 1985, 22(1), 81.
6. Nawwar, G. A. M.; Abdel-Razak, F. M.; Swellam, R. H. Arch. Pharm. (Weinheim) 1991, 324(11), 875.
7. Riad, B. Y.; Abdel Hamid, A. O.; Khalifa, F. A.; Youssry, Y. E. Arch. Pharm. Res.1989, 12(3), 201
8. Esanu, A.; Fr. Demande FR 2,563,223 (Cl. Co 7H19/02), Oct 1985, GB Appl. 84/10,485, Apr 1984; Chem. Abstr. 1986, 105, 172994e.
9. a, M.E.A.Zaki,, Molecules, 1998, 3, 71.
10. b, Nevine A. Abdallah, M.E.A.Zaki, Acta Pharma., 1999, 49, 159.
11. c, S.A.Swelam, O.S. Abd El-Salam and M.E.A.Zaki,, J.Serb. Chem. Soc. 1999, 64 (11), 655.
12. d, M.E.A.Zaki, M.Fernanda Proenca, Brain L.Booth, Journal of Organic Chemistry, 2003; 68(2);282.
13. Arakawa, K.; Miasaka, T.; Ochi, H. Chem. Pharm. Bull. 1974, 22(1),
14. Kuo, S. C.; Huang, L. J.; Nakamura, H. J. Med. Chem: 1984, 27, 539.
15. Reddy, G. S.; Mandell, L.; Galdstein, J. H. J. Chem. Soc. 1963, 1414.
16. Moneer, A. A.; Ismail, M. M.; Osman, A. N.; Fattah, B.; Abdel Ghoneim, K. M.; Egypt. J. Pharm. Sci. 1993, 34, 623.
17. Ismail, K. A.; Abulwafa, O. M.; Koreish, E. Farmaco 1995, 50, 611.
18. Pathak, U.S.; Singh, S.; Padh, J. Indian J. Chem. Sect.B, 1991, 30B, 618.