Biosensor immunosurface engineering inspired by B-cell membrane-bound antibodies: Modeling and analysis of multivalent antigen capture by immobilized antibodies

IEEE Transactions on Nanobioscience

Volumn 2, Issue 1, 2003, Pages 14-25

  Zheng, Yanan ^a   Rundell, Ann ^a  

^a PURDUE UNIVERSITY   (United States)

Author keywords

B lymphocytes; Immobilized receptor binding dynamics; Immunosurface design; Mathematical modeling; Multivalent antigen capture

Indexed keywords

ANTIBODIES; ANTIGEN-ANTIBODY REACTIONS; ANTIGENS; BIOMEDICAL ENGINEERING; CELL MEMBRANES; CHEMICAL BONDS; CROSSLINKING; IMMUNOLOGY; MATHEMATICAL MODELS; OPTIMIZATION;

B LYMPHOCYTES; IMMOBILIZED RECEPTOR BINDING DYNAMICS; IMMUNOSURFACE DESIGNS; MULTIVALENT ANTIGEN CAPTURE;

BIOSENSORS;

BIOMATERIAL; LYMPHOCYTE ANTIGEN RECEPTOR;

ANTIGEN ANTIBODY COMPLEX; ANTIGEN ANTIBODY REACTION; ARTICLE; BIOLOGICAL MODEL; CHEMICAL MODEL; CHEMISTRY; COMPARATIVE STUDY; COMPUTER AIDED DESIGN; COMPUTER SIMULATION; EQUIPMENT; EQUIPMENT DESIGN; EVALUATION; GENETIC PROCEDURES; IMMUNOASSAY; IMMUNOLOGY; INSTRUMENTATION; MATERIALS; METHODOLOGY; NANOTECHNOLOGY; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; VALIDATION STUDY;

ANTIGEN-ANTIBODY COMPLEX; ANTIGEN-ANTIBODY REACTIONS; BIOSENSING TECHNIQUES; COATED MATERIALS, BIOCOMPATIBLE; COMPUTER SIMULATION; COMPUTER-AIDED DESIGN; EQUIPMENT DESIGN; EQUIPMENT FAILURE ANALYSIS; IMMUNOASSAY; MANUFACTURED MATERIALS; MODELS, BIOLOGICAL; MODELS, CHEMICAL; NANOTECHNOLOGY; RECEPTORS, ANTIGEN, B-CELL; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY;

EID: 3042827097     PISSN: 15361241     EISSN: None     Source Type: Journal    
DOI: 10.1109/TNB.2003.810158     Document Type: Article

References (31)

1. B. Alberts, A. Johnson, J. Lewis, M. Raff, K. Roberts, and P. Walter, Molecular Biology of the Cell, 4th ed. New York: Garland, 2002, p. 1375.
2. J. Berzofsky, I. Berkower, and S. Epstein, "Antigen-antibody interactions and monoclonal antibodies," in Fundamental Immunology, 4th ed, W. Paul, Ed. Philadelphia, PA: Lippincott-Raven, 1999.
3. N. Busch, Y. Chiew, M. Yarmush, and M. Wertheim, "Development and validation of a simple antigen-antibody model," AICHE J., vol. 41, no. 4, pp. 974-983, 1995.
4. D. Edwards, B. Goldstein, and D. Cohen, "Transport-effects on surface-volume biological reactions," J. Math. Biol., vol. 39, pp. 533-561, 1999.
5. B. Goldstein and C. Wofsy, "Why is it so hard to dissociate multivalent antigens from cell-surface antibodies?," Immunol. Today, vol. 17, pp. 77-80, 1996.
6. E. Harlow and D. Lane, Using Antibodies: A Laboratory Manual. Cold Spring, NY: Cold Spring Harbor Laboratory Press, 1999.
7. W. Hlavacek, A. Perelson, B. Sulzer, J. Bold, J. Paar, W. Gorman, and R. Posner, "Quantifying aggregation of IgE-FceRI by multivalent antigen," Biophys. J., vol. 76, pp. 2421-2431, 1999.
8. W. Hlavacek, R. Posner, and A. Perelson, "Steric effects on multivalent ligand receptor binding: exclusion of ligand sites by bound cell surface receptors," Biophys. J., vol. 76, pp. 3031-3043, 1999.
9. T. Huang, J. Sturgis, R. Gomez, T. Geng, R. Bashir, A. Bhunia, P. Robinson, and M. Ladisch, "Composite surface for blocking bacterial adsorption on protein biochips," Biotechnol. Bioeng., vol. 81, no. 5, pp. 618-624, Mar. 5, 2003.
10. D. Ivintski, I. Abdel-Hamid, P. Atanasov, and E. Wilkins, "Biosensors for detection of pathogenic bacteria," Biosensors Bioelectron., vol. 4, pp. 599-624, 1999.
11. C. Jolivet-Reynaud, M. Lesenechal, B. O'Donnel, L. Becquart, A. Foussadier, F. Forge, N. Battail-Poirot, X. Lacoux, W. Carman, and M. Jolivet, "Localization of Hepatitis B surface antigen epitopes present on variants and specifically recognized by anti-Hepatitis B surface antigen monoclonal antibodies," J. Med. Virol., vol. 65, pp. 241-249, 2001.
12. D. Lauffenburger and J. Linderman, Receptors: Models for Binding, Trafficking, and Signaling. New York: Oxford Univ. Press, 1993.
13. T. Mason, A. Pineda, C. Wofsy, and B. Goldstein, "Effective rate models for the analysis of transport-dependent biosensor data," Math. Biosci., vol. 159, pp. 123-144, 1999.
14. T. Morton and D. Myszka, "Kinetic analysis of macromolecular interactions using surface plasmon resonance biosensors," Methods Enzymol., vol. 295, pp. 268-295, 1998.
15. D. Myszka, X. He, M. Dembo, T. Morton, and B. Goldstein, "Extending the range of rate constants available from BIACORE: interpreting mass transport-influenced binding data," Biophys. J., vol. 75, pp. 583-594, 1998.
16. E. Nice and B. Catimel, "Instrumental biosensors: new perspectives for the analysis of biomolecular interactions," BioEssays, vol. 21, pp. 339-352, 1999.
17. J. Pancrazio, J. Whelan, D. Borkholder, W. Ma, and D. Stenger, "Development and application of cell-based biosensors," Ann. Biomed. Eng., vol. 27, pp. 697-711, 1999.
18. S. Paek and W. Schramm, "Modeling of immunosensors under nonequilibrium conditions," Anal. Biochem., vol. 196, pp. 319-325, 1991.
19. A. Perelson and C. DeLisi, "Receptor clustering on a cell surface. Part I. Theory of receptor cross-linking by ligands bearing two chemically identical functional groups," Math. Biosci., vol. 48, pp. 71-110, 1980.
20. Z. Peterfi and B. Kocsis, "Comparison of blocking agents for an ELISA for LPS," J. Immunoassay, vol. 21, no. 4, pp. 41-354, 2000.
21. S. Perez-Amodio, P. Holownia, C. Davey, and C. Price, "Effects of the ionic environment, charge, and particle surface chemistry for enhancing a latex homogeneous immunoassay of C-reactive protein," Anal. Chem., vol. 70, pp. 3417-3425, 2001.
22. I. Roitt, J. Brostoff, and D. Male, Immunology, 3rd ed. Philadelphia, PA: Mosby, 1993.
23. V. Schumaker, M. Phillips, and D. Hanson, "Dynamic aspects of antibody structure," Mol Immunol., vol. 28, pp. 1347-1360, 1991.
24. B. Sulzer and A. Perelson, "Equilibrium binding of multivalent ligands to cells: effects of cell and receptor density," Math. Biosci.,vol. 135, pp. 147-185, 1996.
25. J. Turkova, "Oriented immobilization of biologically active proteins as a tool for revealing protein interactions and function," J. Chromatography B, vol. 77, pp. 11-31, 1999.
26. C. Van Oss, "Hydrophobic, hydrophilic and other interactions in epitopeparatope binding," Mol Immunol., vol. 32, no. 3, pp. 199-211, 1995.
27. R. Vijayendran, F. Ligler, and D. Leckband, "A computational reaction-diffusion model for the analysis of transport - limited kinetics," Anal. Chem., vol. 71, pp. 5405-5412, 1999.
28. R. Wade, J. Taveau, and J. Lamy, "Concerning the axial flexibility of the Fab regions of immunoglobulin G.," J. Mol. Biol., vol. 206, pp. 349-356, 1989.
29. B. Waite and E. Chang, "Antibody multivalency effects in the direct binding model for vesicle immunolysis assays," J. Immunol. Methods, vol. 115, pp. 227-238, 1988.
30. T. Webster, "Nanophase ceramics: The future orthopedic and dental implant material," in Adv. Chem. Eng., J. Ying, Ed. New York: Academic Press, 2001, vol. 27, pp. 125-166.
31. B. Weimer, M. Walsh, and X. Wang, "Influence of a poly-ethylene glycol spacer on antigen capture by immobilized antibodies," J. Biochem. Biophys. Methods, vol. 45, pp. 211-219, 2000.