Relation between cortical dopamine D2 receptor occupancy and suppression of conditioned avoidance response in non-human primate

Psychiatry and Clinical Neurosciences

Volumn 58, Issue 3, 2004, Pages 330-332

  Takano, Akihiro ^a,b   Suhara, Tetsuya ^a,b   Maeda, Jun ^a,b   Ando, Kiyoshi ^a,b,c   Okauchi, Takashi ^a,b   Obayashi, Shigeru ^a,b   Nakayama, Takashi ^a,b   Kapur, Shitij ^d  

^a NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c Central Laboratory for Experimental Animals   (Japan)

^d CENTRE FOR ADDICTION AND MENTAL HEALTH   (Canada)

Author keywords

11C FLB 457; Conditioned avoidance response; Dopamine D 2 receptor occupancy; Positron emission tomography

Indexed keywords

CARBON 11; DOPAMINE 2 RECEPTOR; HALOPERIDOL; ISOREMOXIPRIDE; NEUROLEPTIC AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AVOIDANCE BEHAVIOR; CONDITIONING; CONTROLLED STUDY; DOPAMINE RELEASE; DOPAMINERGIC TRANSMISSION; MALE; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIMATE; RECEPTOR OCCUPANCY; RHESUS MONKEY; SCREENING TEST; SPREADING CORTICAL DEPRESSION;

ANIMALS; AVOIDANCE LEARNING; CEREBRAL CORTEX; DOPAMINE ANTAGONISTS; DOSE-RESPONSE RELATIONSHIP, DRUG; HALOPERIDOL; MACACA MULATTA; MALE; PREFRONTAL CORTEX; PYRROLIDINES; RADIOPHARMACEUTICALS; RECEPTORS, DOPAMINE D2; SALICYLAMIDES; TEMPORAL LOBE; TOMOGRAPHY, EMISSION-COMPUTED;

EID: 3042826611     PISSN: 13231316     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1440-1819.2004.01240.x     Document Type: Article

References (19)

1. Wadenberg ML, Hicks PB. The conditioned avoidance response test re-evaluated: is it a sensitive test for the detection of potentially atypical antipsychotics? Neurosci. Biobehav. Rev. 1999; 23: 851-862.
2. 2 dopamine receptor occupancy in patients treated with classical neuroleptics and clozapine. Relation to extrapyramidal side effects. Arch. Gen. Psychiatry 1992; 49: 538-544.
3. 2-dopamine receptors in healthy subjects and antipsychotic drug treated patients. Psychopharmacology 1997; 133: 396-404.
4. Davies JA, Jackson B, Redfern PH. The effect of anti-Parkinsonian drugs on haloperidol-induced inhibition of the conditioned-avoidance response in rats. Neuropharmacology 1973; 12: 735-740.
5. 2 receptor occupancy is a common mechanism underlying animal models of antipsychotics and their clinical effects. Neuropsychopharmacology 2001; 25: 633-641.
6. 11C]FLB 457 binding measured by PET. Synapse 2001; 41: 87-95.
7. Pilowsky LS, Mulligan RS, Acton PD, Ell PJ, Costa DC, Kerwin RW. Limbic selectivity of clozapine. Lancet 1997; 350: 490-491.
8. Lidow MS, Williams GV, Goldman-Rakic PS. The cerebral cortex: a case for a common site of action of antipsychotics. Trends Pharmacol. Sci. 1998; 19: 136-140.
9. Lammertsma AA. Simplified reference tissue model for PET receptor studies. Neuroimage 1996; 4: 153-158.
10. 2 receptor density and affinity in the human brain measured by 3D PET. Int. J. Neuropsychopharmcol. 1999; 2: 73-82.
11. 2-dopamine receptor occupancy in relation to antipsychotic drug effects: a double-blind PET study of schizophrenic patients. Biol. Psychiatry 1993; 33: 227-235.
12. 2 occupancy, clinical response, and side effects: a double-blind PET study of first-episode schizophrenia. Am. J. Psychiatry 2000; 157: 514-520.
13. 11C]FLB 457. Am. J. Psychiatry 2001; 158: 926-930.
14. Wadenberg ML, Ericson E, Magnusson O, Ahlenius S. Suppression of conditioned avoidance behavior by the local application of (-) sulpiride into the ventral, but not the dorsal, striatum of the rat. Biol. Psychiatry 1990; 28: 297-307.
15. Stark H, Bischof A, Scheich H. Increase of extracellular dopamine in prefrontal cortex of gerbils during acquisition of the avoidance strategy in the shuttle-box. Neurosci. Lett. 1999; 264: 77-80.
16. Jinks AL, McGregor IS. Modulation of anxiety-related behaviours following lesions of the prelimbic or infralimbic cortex in the rat. Brain Res. 1997; 772: 181-190.
17. Roozendaal B, Koolhaas JM, Bohus B. The central amygdala is involved in conditioning but not in retention of active and passive shock avoidance in male rats. Behav. Neural Biol. 1993; 59: 143-149.
18. 2-dopamine receptor occupancy examined by PET after single oral doses of haloperidol. Psychopharmacology 1992; 106: 433-438.
19. Main DC, Waterman AE, Kilpatrick IC. Behavioural analysis of changes in nociceptive thresholds produced by remoxipride in sheep and rats. Eur. J. Pharmacol. 1995; 287: 221-231.