A mouse model for evaluation of capillary perfusion, microvascular permeability, cortical blood flow, and cortical edema in the traumatized brain

Journal of Neurotrauma

Volumn 21, Issue 6, 2004, Pages 741-753

  Lundblad, Cornelia ^a   Grande P O ^a   Bentzer, P ^a  

^a LUND UNIVERSITY   (Sweden)

Author keywords

Brain trauma; Capillary perfuison; Cerebral blood flow; Edema; Microvascular permeability; Secondary injury and ischemia

Indexed keywords

PHENAZONE I 125;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD VESSEL PERMEABILITY; BRAIN BLOOD FLOW; BRAIN CORTEX; BRAIN EDEMA; BRAIN INJURY; BRAIN PERFUSION; BRAIN WATER; CAPILLARY FLOW; CELL DEATH; CONTROLLED STUDY; GENETIC ENGINEERING; HEMISPHERE; HEMODYNAMIC MONITORING; MICROVASCULATURE; MOUSE; NONHUMAN; TISSUE DISTRIBUTION;

ANIMALS; BRAIN EDEMA; CAPILLARIES; CAPILLARY PERMEABILITY; CEREBRAL CORTEX; CEREBROVASCULAR CIRCULATION; DISEASE MODELS, ANIMAL; EXTRACELLULAR FLUID; MALE; MICE; MICE, INBRED C57BL;

EID: 3042816807     PISSN: 08977151     EISSN: None     Source Type: Journal    
DOI: 10.1089/0897715041269614     Document Type: Article

References (52)

1. ARAKAWA, M., JEROME, E.H., ENZAN, K., et al. (1990). Effects of dextran 70 on hemodynamics and lung liquid and protein exchange in awake sheep. Circ. Res. 67, 852-861.
2. ASTRUP, J., SIESJÖ, B.K., and SYMON, L. (1981). Thresholds in cerebral ischemia-the ischemic penumbra. Stroke 12, 723-725.
3. BENTZER, P., MATTIASSON, G., MCINTOSH, T.K., et al. (2001). Infusion of prostacyclin following experimental brain injury in the rat reduces cortical lesion volume. J. Neurotrauma 18, 275-285.
4. BENTZER, P., VENTUROLI, D., CARLSSON, O., et al. (2003). Low-dose prostacyclin improves cortical perfusion following experimental brain injury in the rat. J. Neurotrauma 20, 447-461.
5. BLASBERG, R.G., FENSTERMACHER, J.D., and PATLAK, C.S. (1983). Transport of alpha-aminoisobutyric acid across brain capillary and cellular membranes. J. Cereb. Blood Flow Metab. 3, 8-32.
6. BRYAN, R.M., JR., CHERIAN, L., and ROBERTSON, C. (1995). Regional cerebral blood flow after controlled cortical impact injury in rats. Anesth. Analg. 80, 687-695.
7. BULLOCK, R., STATHAM, P., PATTERSON, J., et al. (1990). The time course of vasogenic oedema after focal human head injury-evidence from SPECT mapping of blood brain barrier defects. Acta Neurochir. Suppl. (Wien) 51, 286-288.
8. CHERIAN, L., ROBERTSON, C.S., CONTANT, C.F., JR., et al. (1994). Lateral cortical impact injury in rats: cerebrovascular effects of varying depth of cortical deformation and impact velocity. J. Neurotrauma 11, 573-585.
9. FENSTERMACHER, J. (1984). Volume regulation of the central nervous system, in: Edema A.T. Staub (ed), Raven Press: New York, pps. 383-404.
10. FENSTERMACHER, J.D., BLASBERG, R.G., and PATLAK, C.S. (1981). Methods for quantifying the transport of drugs across brain barrier systems. Pharmacol. Ther. 14, 217-248.
11. GINSBERG, M.D., ZHAO, W., ALONSO, O.F., et al. (1997). Uncoupling of local cerebral glucose metabolism and blood flow after acute fluid-percussion injury in rats. Am. J. Physiol. 272, H2859-H2868.
12. GOLDING, E.M., ROBERTSON, C.S., and BRYAN, R.M., JR. (1999). The consequences of traumatic brain injury on cerebral blood flow and autoregulation: a review. Clin. Exp. Hypertens. 21, 299-332.
13. GRAHAM, D.I., FORD, I., ADAMS, J.H., et al. (1989). Ischaemic brain damage is still common in fatal non-missile head injury. J. Neurol. Neurosurg. Psychiatry 52, 346-350.
14. GRÄNDE, P.O., ASGEIRSSON, B., and NORDSTRÖM, C.H. (1997a). Aspects on the cerebral perfusion pressure during therapy of a traumatic head injury. Acta Anaesthesiol. Scand. Suppl. 110, 36-40.
15. GRÄNDE, P.O., ASGEIRSSON, B., and NORDSTRÖM, C.H. (1997b). Physiologic principles for volume regulation of a tissue enclosed in a rigid shell with application to the injured brain. J. Trauma 42, S23-S31.
16. GUENIAU, C., and OBERLANDER, C. (1997). The kappa opioid agonist niravoline decreases brain edema in the mouse middle cerebral artery occlusion model of stroke. J. Pharmacol. Exp. Ther. 282, 1-6.
17. GÖBEL, U., KLEIN, B., SCHRÖCK, H., et al. (1989). Lack of capillary recruitment in the brains of awake rats during hypercapnia. J. Cereb. Blood Flow Metab. 9, 491-499.
18. GÖBEL, U., THEILEN, H., and KUSCHINSKY, W. (1990). Congruence of total and perfused capillary network in rat brains. Circ. Res. 66, 271-281.
19. HEKMATPANAH, J., and HEKMATPANAH, C.R. (1985). Microvascular alterations following cerebral contusion in rats. Light, scanning, and electron microscope study. J. Neurosurg. 62, 888-897.
20. HOLBECK, S., BENTZER, P., WIKSTRAND, C., et al. (2001). Dextran, gelatin, and hydroxyethyl starch do not affect permeability for albumin in cat skeletal muscle. Crit. Care Med. 29, 123-128.
21. HOLMIN, S., SÖDERLUND, J., BIBERFELD, P., et al. (1998). Intracerebral inflammation after human brain contusion. Neurosurgery 42, 291-299.
22. 14C]iodoantipyrine in the mouse. J. Cereb. Blood Flow Metab. 8, 121-129.
23. KOCHANEK, P.M., MARION, D.W., ZHANG, W., et al. (1995). Severe controlled cortical impact in rats: assessment of cerebral edema, blood flow, and contusion volume. J. Neurotrauma 12, 1015-1025.
24. 51Cr EDTA equilibration volumes of different tissues in the rat. Acta Physiol. Scand. 110, 53-57.
25. LIU, H., GOODMAN, J.C., and ROBERTSON, C.S. (2002). The effects of L-arginine on cerebral hemodynamics after controlled cortical impact injury in the mouse. J. Neurotrauma 19, 327-334.
26. LONGHI, L., SAATMAN, K.E., RAGHUPATHI, R., et al. (2001). A review and rationale for the use of genetically engineered animals in the study of traumatic brain injury. J. Cereb. Blood Flow Metab. 21, 1241-1258.
27. 14C]iodoantipyrine injection and final arterial heart blood sampling. J. Cereb. Blood Flow Metab. 20, 10-14.
28. MAEDA, T., KATAYAMA, Y., KAWAMATA, T., et al. (1997). Hemodynamic depression and microthrombosis in the peripheral areas of cortical contusion in the rat: role of platelet activating factor. Acta Neurochir. Suppl. (Wien) 70, 102-105.
29. MIES, G., ISHIMARU, S., XIE, Y., et al. (1991). Ischemic thresholds of cerebral protein synthesis and energy state following middle cerebral artery occlusion in rat. J. Cereb. Blood Flow Metab. 11, 753-761.
30. MILLER, J.D., SWEET, R.C., NARAYAN, R., et al. (1978). Early insults to the injured brain. JAMA 240, 439-442.
31. NAREDI, S., OLIVECRONA, M., LINDGREN, C., et al. (2001). An outcome study of severe traumatic head injury using the "Lund therapy" with low-dose prostacyclin. Acta Anaesthesiol. Scand. 45, 402-406.
32. OBRIST, W.D., LANGFITT, T.W., JAGGI, J.L., et al. (1984). Cerebral blood flow and metabolism in comatose patients with acute head injury. Relationship to intracranial hypertension. J. Neurosurg. 61, 241-253.
33. PAXINOS, G., and FRANKLIN, K. (2001). The Mouse Brain in Stereotaxic Coordinates. Academic Press: San Diego.
34. PETROV, T., and RAFOLS, J.A. (2001). Acute alterations of endothelin-1 and iNOS expression and control of the brain microcirculation after head trauma. Neurol. Res. 23, 139-143.
35. POVLISHOCK, J.T., BECKER, D.P., SULLIVAN, H.G., et al. (1978). Vascular permeability alterations to horseradish peroxidase in experimental brain injury. Brain Res. 153, 223-239.
36. RENKIN, E. (1984). Control of microcirculation and blood-tissue exchange, in: Handbook of Physiology. M. Bethesda (ed), Am. Physiol. Soc.: Baltimore, pp. 627-687.
37. ROSNER, M.J., and DAUGHTON, S. (1990). Cerebral perfusion pressure management in head injury. J. Trauma 30, 933-941.
38. 14C] antipyrine. Am. J. Physiol. 234, H59-H66.
39. SARNA, G.S., BRADBURY, M.W., and CAVANAGH, J. (1977). Permeability of the blood-brain barrier after portocaval anastomosis in the rat. Brain Res. 138, 550-554.
40. SHAPIRA, Y., SETTON, D., ARTRU, A.A., et al. (1993). Blood-brain barrier permeability, cerebral edema, and neurologic function after closed head injury in rats. Anesth. Analg. 77, 141-148.
41. SMITH, D.H., SOARES, H.D., PIERCE, J.S., et al. (1995). A model of parasagittal controlled cortical impact in the mouse: cognitive and histopathologic effects. J. Neurotrauma 12, 169-178.
42. STEINBAUER, M., HARRIS, A.G., LEIDERER, R., et al. (1998). Impact of dextran on microvascular disturbances and tissue injury following ischemia/reperfusion in striated muscle. Shock 9, 345-351.
43. VILLRINGER, A., THEM, A., LINDAUER, U., et al. (1994). Capillary perfusion of the rat brain cortex. An in vivo confocal microscopy study. Circ. Res. 75, 55-62.
44. VON OETTINGEN, G., BERGHOLT, B., GYLDENSTED, C., et al. (2002). Blood flow and ischemia within traumatic cerebral contusions. Neurosurgery 50, 781-790.
45. WANIEWSKI, J., HEIMBURGER, O., WERYNSKI, A., et al. (1992). Aqueous solute concentrations and evaluation of mass transport coefficients in peritoneal dialysis. Nephrol. Dial. Transplant. 7, 50-56.
46. WEISS, H.R. (1988). Measurement of cerebral capillary perfusion with a fluorescent label. Microvasc. Res. 36, 172-180.
47. WELLONS, J.C., III, SHENG, H., LASKOWITZ, D.T., et al. (2000). A comparison of strain-related susceptibility in two murine recovery models of global cerebral ischemia. Brain Res. 868, 14-21.
48. WHALEN, M.J., CARLOS, T.M., DIXON, C.E., et al. (2000). Reduced brain edema after traumatic brain injury in mice deficient in P-selectin and intercellular adhesion molecule-1. J. Leukoc. Biol. 67, 160-168.
49. YAMAKAMI, I., and MCINTOSH, T.K. (1989). Effects of traumatic brain injury on regional cerebral blood flow in rats as measured with radiolabeled microspheres. J. Cereb. Blood Flow Metab. 9, 117-124.
50. YANG, G.Y., ZHAO, Y.J., DAVIDSON, B.L., et al. (1997). Overexpression of interleukin-1 receptor antagonist in the mouse brain reduces ischemic brain injury. Brain Res. 751, 181-188.
51. ZHANG, C., RAGHUPATHI, R., SAATMAN, K.E., et al. (1998). Riluzole attenuates cortical lesion size, but not hippocampal neuronal loss, following traumatic brain injury in the rat. J. Neurosci. Res. 52, 342-349.
52. ZOCCOLI, G., LUCCHI, M.L., ANDREOLI, E., et al. (2000). Density of perfused brain capillaries in the aged rat during the wake-sleep cycle. Exp. Brain Res. 130, 73-77.