Hyperthermia modifies pharmacokinetics and tissue distribution of intraperitoneal melphalan in a rat model

Cancer Chemotherapy and Pharmacology

Volumn 54, Issue 1, 2004, Pages 79-84

  Glehen, O ^a   Stuart, O A ^b   Mohamed, F ^b   Sugarbaker, P H ^b  

^a CENTRE HOSPITALIER LYON SUD   (France)

^b WASHINGTON CANCER INSTITUTE   (United States)

Author keywords

Hyperthermia; Intraperitoneal chemotherapy; Melphalan; Pharmacokinetics

Indexed keywords

MELPHALAN;

ABDOMINAL WALL; ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; COLON; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG DOSE REGIMEN; DRUG PERITONEAL FLUID LEVEL; DRUG SCREENING; HEART; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYPERTHERMIA; ILEUM; JEJUNUM; LIVER; MALE; NONHUMAN; OMENTUM; PRIORITY JOURNAL; RANDOMIZATION; RAT; TEMPERATURE DEPENDENCE; TISSUE DISTRIBUTION; TISSUE SECTION;

ANIMALS; ANTINEOPLASTIC AGENTS, ALKYLATING; AREA UNDER CURVE; DISEASE MODELS, ANIMAL; HYPERTHERMIA, INDUCED; INFUSIONS, PARENTERAL; MALE; MELPHALAN; PERITONEAL NEOPLASMS; RATS; RATS, SPRAGUE-DAWLEY; TISSUE DISTRIBUTION;

EID: 3042805399     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00280-004-0779-0     Document Type: Article

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