메뉴 건너뛰기




Volumn 11, Issue 1, 2004, Pages 10-21

Combination therapy for multiple sclerosis

Author keywords

Combination therapy; Excitotoxicity; Fixed dose regimen; Immune mediated inflammatory cascade; Oxidative toxicity; Sequential combination regimen

Indexed keywords

AZATHIOPRINE; BETA INTERFERON; CD4 ANTIGEN; CD8 ANTIGEN; CYCLOPHOSPHAMIDE; DACLIZUMAB; FLUOCORTOLONE; FLUOXETINE; GLATIRAMER; IBUPROFEN; IMMUNOGLOBULIN; IMMUNOMODULATING AGENT; INOSINE; METACYCLINE; METHOTREXATE; METHYLPREDNISOLONE; MITOXANTRONE; MIZORIBINE; MOCLOBEMIDE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; NATALIZUMAB; PARACETAMOL; PENICILLAMINE; PENTOXIFYLLINE; PREDNISONE; RETINOIC ACID; SALBUTAMOL; SELEGILINE; TACROLIMUS; UNINDEXED DRUG;

EID: 3042787735     PISSN: 13528963     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (4)

References (68)
  • 1
    • 0031878664 scopus 로고    scopus 로고
    • Combination therapy for treatment of multiple sclerosis
    • Lublin FD, Reingold SC. Combination therapy for treatment of multiple sclerosis. Ann Neurol 1998; 44: 7-10.
    • (1998) Ann Neurol , vol.44 , pp. 7-10
    • Lublin, F.D.1    Reingold, S.C.2
  • 2
    • 0342906187 scopus 로고    scopus 로고
    • Heterogeneity of multiple sclerosis lesions: Implications for the pathogenesis of demyelination
    • Lucchinetti C, Bruck W, Parisi J, Scheithauer B, Rodriguez M. Heterogeneity of multiple sclerosis lesions: Implications for the pathogenesis of demyelination. Ann Neurol 2000; 47: 707-718.
    • (2000) Ann Neurol , vol.47 , pp. 707-718
    • Lucchinetti, C.1    Bruck, W.2    Parisi, J.3    Scheithauer, B.4    Rodriguez, M.5
  • 3
    • 0032915309 scopus 로고    scopus 로고
    • Neurodegeneration in multiple sclerosis: Relationship to neurological disability
    • Trapp BD, Ransohoff RM, Fisher E, Rudick RA. Neurodegeneration in multiple sclerosis: relationship to neurological disability. Neuroscientist 1999; 5: 48-57.
    • (1999) Neuroscientist , vol.5 , pp. 48-57
    • Trapp, B.D.1    Ransohoff, R.M.2    Fisher, E.3    Rudick, R.A.4
  • 4
    • 0037530542 scopus 로고    scopus 로고
    • Vulnerability of human neurons to T-cell-mediated cytotoxicity
    • Giuliano F, Goodyer CG, Antel JP, Yong VW. Vulnerability of human neurons to T-cell-mediated cytotoxicity. J Immunol 2003; 171: 368-379.
    • (2003) J Immunol , vol.171 , pp. 368-379
    • Giuliano, F.1    Goodyer, C.G.2    Antel, J.P.3    Yong, V.W.4
  • 5
    • 0034911054 scopus 로고    scopus 로고
    • Multiple sclerosis: Altered glutamate homeostasis in lesions correlates with oligodendrocyte and axonal damage
    • Werner P, Pitt D. Multiple sclerosis: altered glutamate homeostasis in lesions correlates with oligodendrocyte and axonal damage. Ann Neurol 2001; 50: 169-181.
    • (2001) Ann Neurol , vol.50 , pp. 169-181
    • Werner, P.1    Pitt, D.2
  • 6
    • 0028835098 scopus 로고
    • Additive effects of copolymer-1 and interferon beta-1b on the immune response to myelin basic protein
    • Milo R, Panitch H. Additive effects of copolymer-1 and interferon beta-1b on the immune response to myelin basic protein. J Neuroimmunol 1995; 61: 185-193.
    • (1995) J Neuroimmunol , vol.61 , pp. 185-193
    • Milo, R.1    Panitch, H.2
  • 7
    • 0033960042 scopus 로고    scopus 로고
    • Combination therapy with glatiramer acetate (copolymer-1) and a type I interferon (IFN-alpha) does not improve experimental autoimmune encephalomyelitis
    • Brod SA, Lindsey JW, Wolinsky JS. Combination therapy with glatiramer acetate (copolymer-1) and a type I interferon (IFN-alpha) does not improve experimental autoimmune encephalomyelitis. Ann Neurol 2000; 47: 127-131.
    • (2000) Ann Neurol , vol.47 , pp. 127-131
    • Brod, S.A.1    Lindsey, J.W.2    Wolinsky, J.S.3
  • 8
    • 3042843291 scopus 로고    scopus 로고
    • Immune regulatory properties and interactions of copolymer-1 and beta-interferon 1a in multiple sclerosis
    • AAN 55th Annual Meeting
    • Ying C, Zang Q, Hong J, Robinson RR, Li S, Rivera VM et al. Immune regulatory properties and interactions of copolymer-1 and beta-interferon 1a in multiple sclerosis. AAN 55th Annual Meeting. Neurology 2003; 60 (Suppl 1): A394.
    • (2003) Neurology , vol.60 , Issue.SUPPL. 1
    • Ying, C.1    Zang, Q.2    Hong, J.3    Robinson, R.R.4    Li, S.5    Rivera, V.M.6
  • 9
    • 0036892091 scopus 로고    scopus 로고
    • Effect of combined IFNβ-1a and glatiramer acetate therapy on GA-specific T-cell responses in multiple sclerosis
    • Dhib-Jalbut S, Chen M, Henschel K, Ford D, Costello K, Panitch H. Effect of combined IFNβ-1a and glatiramer acetate therapy on GA-specific T-cell responses in multiple sclerosis. Mult Scler 2002; 8: 485-491.
    • (2002) Mult Scler , vol.8 , pp. 485-491
    • Dhib-Jalbut, S.1    Chen, M.2    Henschel, K.3    Ford, D.4    Costello, K.5    Panitch, H.6
  • 10
    • 0009520652 scopus 로고    scopus 로고
    • Results of the extension of a trial to assess longer term safety of combining interferon beta-1a and glatiramer acetate
    • AAN 54th Annual Meeting
    • Lublin F, Baier M, Cutter G, Bever C, Elfont R, Khan O et al. Results of the extension of a trial to assess longer term safety of combining interferon beta-1a and glatiramer acetate. AAN 54th Annual Meeting. Neurology 2002; 58 (Suppl 3): A85.
    • (2002) Neurology , vol.58 , Issue.SUPPL. 3
    • Lublin, F.1    Baier, M.2    Cutter, G.3    Bever, C.4    Elfont, R.5    Khan, O.6
  • 11
    • 23544476104 scopus 로고    scopus 로고
    • Induction treatment with the monthly combination mitoxantrone- methylprednisolone for six months followed by a maintenance therapy in worsening relapsing-remitting MS: The clinical benefits last at least four years
    • AAN 54th Annual Meeting
    • Le Page E, Coustans M, Taurin G, Chaperon J, Edan G. Induction treatment with the monthly combination mitoxantrone-methylprednisolone for six months followed by a maintenance therapy in worsening relapsing-remitting MS: The clinical benefits last at least four years. AAN 54th Annual Meeting. Neurology 2002; 58 (Suppl 3): A187.
    • (2002) Neurology , vol.58 , Issue.SUPPL. 3
    • Le Page, E.1    Coustans, M.2    Taurin, G.3    Chaperon, J.4    Edan, G.5
  • 12
    • 3042843290 scopus 로고    scopus 로고
    • The role of intensive immunosuppresion in multiple sclerosis: Prospects of combinations
    • (Kappos L, Kesselring J, Radü EW, Johnson K, eds). London: Martin Dunitz Ltd
    • Edan G and the Mitoxantrone-Interferon-β-1b European Multicentre Trial Group. The role of intensive immunosuppresion in multiple sclerosis: prospects of combinations. In: Multiple Sclerosis: Tissue Destruction and Repair (Kappos L, Kesselring J, Radü EW, Johnson K, eds). London: Martin Dunitz Ltd, 2001; pp285-290.
    • (2001) Multiple Sclerosis: Tissue Destruction and Repair , pp. 285-290
    • Edan, G.1
  • 13
    • 23544440564 scopus 로고    scopus 로고
    • The effect of combination therapy with interferon beta-1b and mitoxantrone on enhancing lesion frequency and on the proportion enhancing lesions evolving into T1 'black holes'
    • ECTRIMS 19th Congress
    • Jeffery D, Zhu J, Chapuri N, Tan J. The effect of combination therapy with interferon beta-1b and mitoxantrone on enhancing lesion frequency and on the proportion enhancing lesions evolving into T1 'black holes'. ECTRIMS 19th Congress. Mult Scler 2003; 9 (Suppl 1): S70.
    • (2003) Mult Scler , vol.9 , Issue.SUPPL. 1
    • Jeffery, D.1    Zhu, J.2    Chapuri, N.3    Tan, J.4
  • 14
    • 3042721225 scopus 로고    scopus 로고
    • A pilot safety and tolerability study of interferon beta 1a in combination with azathioprine in multiple sclerosis
    • AAN 53rd Annual Meeting
    • Moreau T, Blanc S, Riche G, Nony P, Confavreux C. A pilot safety and tolerability study of interferon beta 1a in combination with azathioprine in multiple sclerosis. AAN 53rd Annual Meeting. Neurology 2001; 56 (Suppl 3): A353.
    • (2001) Neurology , vol.56 , Issue.SUPPL. 3
    • Moreau, T.1    Blanc, S.2    Riche, G.3    Nony, P.4    Confavreux, C.5
  • 15
    • 18544362086 scopus 로고    scopus 로고
    • Combination therapy with interferon beta-1b and azathioprine in secondary progressive multiple sclerosis. A two-year pilot study
    • Fernandez O, Guerrero M, Mayorga C, Munoz L, Lean A, Luque G et al. Combination therapy with interferon beta-1b and azathioprine in secondary progressive multiple sclerosis. A two-year pilot study. J Neurol 2002; 249: 1058-1062.
    • (2002) J Neurol , vol.249 , pp. 1058-1062
    • Fernandez, O.1    Guerrero, M.2    Mayorga, C.3    Munoz, L.4    Lean, A.5    Luque, G.6
  • 16
    • 23544482314 scopus 로고    scopus 로고
    • Interferon beta-1a in combination with azathioprine and low-dose steroids for relapsing-remitting multiple sclerosis - Preliminary clinical and MRI data from a 2-year double-blind, randomised, placebo-controlled study
    • ECTRIMS 19th Congress
    • Horakova D, Havrdova E, Krasensky J, Jinochova M, Dolezal O, Meluzinova E et al. Interferon beta-1a in combination with azathioprine and low-dose steroids for relapsing-remitting multiple sclerosis - preliminary clinical and MRI data from a 2-year double-blind, randomised, placebo-controlled study. ECTRIMS 19th Congress. Mult Scler 2003; 9 (Suppl 1): S144.
    • (2003) Mult Scler , vol.9 , Issue.SUPPL. 1
    • Horakova, D.1    Havrdova, E.2    Krasensky, J.3    Jinochova, M.4    Dolezal, O.5    Meluzinova, E.6
  • 17
    • 0038115303 scopus 로고    scopus 로고
    • Longitudinal MRI study: The effects of azathioprine in MS patients refractory to interferon beta-1b
    • Markovic-Plese S, Bielekova B, Kadom N, Leist TP, Martin R, Frank JA et al. Longitudinal MRI study: the effects of azathioprine in MS patients refractory to interferon beta-1b. Neurology 2003; 60: 1849-1851.
    • (2003) Neurology , vol.60 , pp. 1849-1851
    • Markovic-Plese, S.1    Bielekova, B.2    Kadom, N.3    Leist, T.P.4    Martin, R.5    Frank, J.A.6
  • 18
    • 23544459198 scopus 로고    scopus 로고
    • A safety study of combination treatment with interferon beta-1a (Avonex) and azathioprine in breakthrough multiple sclerosis
    • ECTRIMS 19th Congress
    • Greenstein J, Rae-Grant AD, Eckert N. A safety study of combination treatment with interferon beta-1a (Avonex) and azathioprine in breakthrough multiple sclerosis. ECTRIMS 19th Congress. Mult Scler 2003; 9 (Suppl 1): S140.
    • (2003) Mult Scler , vol.9 , Issue.SUPPL. 1
    • Greenstein, J.1    Rae-Grant, A.D.2    Eckert, N.3
  • 19
    • 23544466032 scopus 로고    scopus 로고
    • Interactions of IFNb and azathioprine association in vitro and in multiple sclerosis
    • ECTRIMS 19th Congress
    • Aldinucci A, Biagioli T, Mozzanti B, Ballerini C, Vergelli M, Massacesi L. Interactions of IFNb and azathioprine association in vitro and in multiple sclerosis. ECTRIMS 19th Congress. Mult Scler 2003; 9 (Suppl 1): S78.
    • (2003) Mult Scler , vol.9 , Issue.SUPPL. 1
    • Aldinucci, A.1    Biagioli, T.2    Mozzanti, B.3    Ballerini, C.4    Vergelli, M.5    Massacesi, L.6
  • 20
    • 23544473042 scopus 로고    scopus 로고
    • Safety profile of azathioprine and interferon beta-1a association, in relapsing-remitting multiple sclerosis
    • ECTRIMS 19th Congress
    • Recipe A, Parigi A, Berilaro A, Taluti R, Massacesi L. Safety profile of azathioprine and interferon beta-1a association, in relapsing-remitting multiple sclerosis. ECTRIMS 19th Congress. Mult Scler 2003; 9 (Suppl 1): S29.
    • (2003) Mult Scler , vol.9 , Issue.SUPPL. 1
    • Recipe, A.1    Parigi, A.2    Berilaro, A.3    Taluti, R.4    Massacesi, L.5
  • 21
    • 0036197846 scopus 로고    scopus 로고
    • Treatment of multiple sclerosis with cyclophosphomide: Critical review of clinical and immunological effects
    • Weiner HL, Cohan JA. Treatment of multiple sclerosis with cyclophosphomide: critical review of clinical and immunological effects. Mult Scler 2002; 8: 142-154.
    • (2002) Mult Scler , vol.8 , pp. 142-154
    • Weiner, H.L.1    Cohan, J.A.2
  • 22
    • 3042843289 scopus 로고    scopus 로고
    • Rapidly transitional multiple sclerosis patients treated with combination of cyclophosphamide and interferon beta: Follow-up 36 months after discontinuation of therapy
    • AAN 55th Annual Meeting
    • Patti F, Reggio E, Fiorillo T, Nicoletti A, Palermo F, Reggio A. Rapidly transitional multiple sclerosis patients treated with combination of cyclophosphamide and interferon beta: follow-up 36 months after discontinuation of therapy. AAN 55th Annual Meeting. Neurology 2003; 60 (Suppl 1): A148.
    • (2003) Neurology , vol.60 , Issue.SUPPL. 1
    • Patti, F.1    Reggio, E.2    Fiorillo, T.3    Nicoletti, A.4    Palermo, F.5    Reggio, A.6
  • 23
    • 3042727602 scopus 로고    scopus 로고
    • Design of randomized, blinded, MRI trial of pulse cyclophosphamide rescue therapy in B-IFN resistant active MS
    • AAN 53rd Annual Meeting
    • Smith DR, Weinstock-Guttmann B, Cohen JA, Guttmann C, Olek MJ, Stuart WH et al. Design of randomized, blinded, MRI trial of pulse cyclophosphamide rescue therapy in B-IFN resistant active MS. AAN 53rd Annual Meeting. Neurology 2001; 56 (Suppl 3): A356.
    • (2001) Neurology , vol.56 , Issue.SUPPL. 3
    • Smith, D.R.1    Weinstock-Guttmann, B.2    Cohen, J.A.3    Guttmann, C.4    Olek, M.J.5    Stuart, W.H.6
  • 24
    • 3042848098 scopus 로고    scopus 로고
    • Safety and tolerability of the combination of interferon beta-1a and oral cyclophosphamide for patients with multiple sclerosis
    • AAN 53rd Annual Meeting
    • Kaufman M, Norton J, Sonnenfeld G. Safety and tolerability of the combination of interferon beta-1a and oral cyclophosphamide for patients with multiple sclerosis. AAN 53rd Annual Meeting. Neurology 2001; 56 (Suppl 3): A354.
    • (2001) Neurology , vol.56 , Issue.SUPPL. 3
    • Kaufman, M.1    Norton, J.2    Sonnenfeld, G.3
  • 25
    • 23544436609 scopus 로고    scopus 로고
    • Association of interferon beta and cyclophosphamide in patients with multiple sclerosis
    • ECTRIMS 19th Congress
    • Totaro R, Russo T, Marini C, Carolei A. Association of interferon beta and cyclophosphamide in patients with multiple sclerosis. ECTRIMS 19th Congress. Multiple Sclerosis 2003; 9 (Suppl 1): S78.
    • (2003) Multiple Sclerosis , vol.9 , Issue.SUPPL. 1
    • Totaro, R.1    Russo, T.2    Marini, C.3    Carolei, A.4
  • 26
    • 0029854588 scopus 로고    scopus 로고
    • Low-dose oral methotrexate in chronic progressive multiple sclerosis. Analyses of serial MRIs
    • Goodkin DE, Rudick RA, Vanderbrug Medendorp S, Doughtry MM. Low-dose oral methotrexate in chronic progressive multiple sclerosis. Analyses of serial MRIs. Neurology 1996; 47: 1153-1157.
    • (1996) Neurology , vol.47 , pp. 1153-1157
    • Goodkin, D.E.1    Rudick, R.A.2    Vanderbrug Medendorp, S.3    Doughtry, M.M.4
  • 27
    • 0037154138 scopus 로고    scopus 로고
    • An open-label trial of combination therapy with interferon beta-1a and oral methotrexate in MS
    • Calabresi PA, Wilterdink JL, Rogg JM, Mills P, Webb A, Whartenby KA. An open-label trial of combination therapy with interferon beta-1a and oral methotrexate in MS. Neurology 2002; 58: 314-317.
    • (2002) Neurology , vol.58 , pp. 314-317
    • Calabresi, P.A.1    Wilterdink, J.L.2    Rogg, J.M.3    Mills, P.4    Webb, A.5    Whartenby, K.A.6
  • 28
    • 3042763714 scopus 로고    scopus 로고
    • Rescue therapy with high dose intravenous methotrexate in MS patients worsening despite Avonex therapy
    • AAN 55th Annual Meeting
    • Rowe VD, Wang D, John HA, Dressman LA, Rowe ES, Moreng GR. Rescue therapy with high dose intravenous methotrexate in MS patients worsening despite Avonex therapy. AAN 55th Annual Meeting. Neurology 2003; 60 (Suppl 1): A149.
    • (2003) Neurology , vol.60 , Issue.SUPPL. 1
    • Rowe, V.D.1    Wang, D.2    John, H.A.3    Dressman, L.A.4    Rowe, E.S.5    Moreng, G.R.6
  • 29
    • 3042805994 scopus 로고    scopus 로고
    • Rationale and design of the Avonex combination trial
    • ECTRIMS 19th Congress
    • Cohen J, Antel J, Calabresi P, Fisher E, Goodkin D, Goodman A et al. for the ACT Investigators. Rationale and design of the Avonex combination trial. ECTRIMS 19th Congress. Mult Scler 2003; 9 (Suppl 1): S139-S140.
    • (2003) Mult Scler , vol.9 , Issue.SUPPL. 1
    • Cohen, J.1    Antel, J.2    Calabresi, P.3    Fisher, E.4    Goodkin, D.5    Goodman, A.6
  • 30
    • 0034887124 scopus 로고    scopus 로고
    • Mycophenolate mofetil treatment accelerates recovery from experimental allergic encephalomyelitis
    • Tran GT, Carter N, Hodgkinson SJ. Mycophenolate mofetil treatment accelerates recovery from experimental allergic encephalomyelitis. Int Immunopharmacol 2001; 1: 1709-1723.
    • (2001) Int Immunopharmacol , vol.1 , pp. 1709-1723
    • Tran, G.T.1    Carter, N.2    Hodgkinson, S.J.3
  • 31
    • 3042843287 scopus 로고    scopus 로고
    • Combination of interferon beta-1a (Avonex) and mycophenolate mofetil (Cellcept) phase II trial in relapsing-remitting multiple sclerosis
    • ECTRIMS 19th Congress
    • Vermersch P, Waucquier N, Bourteel H, Stojkovic T, Fernby D, Michelin E et al. on behalf of the G-SEP. Combination of interferon beta-1a (Avonex) and mycophenolate mofetil (Cellcept) phase II trial in relapsing-remitting multiple sclerosis. ECTRIMS 19th Congress. Mult Scler 2003; 9 (Suppl 1): S18.
    • (2003) Mult Scler , vol.9 , Issue.SUPPL. 1
    • Vermersch, P.1    Waucquier, N.2    Bourteel, H.3    Stojkovic, T.4    Fernby, D.5    Michelin, E.6
  • 32
    • 0028609529 scopus 로고
    • Influence of FK 506 (tacrolimus) on circulating CD4+ T cells expressing CD25 and CD45RA antigens in 19 patients with chronic progressive multiple sclerosis participating in an open label drug safety trial
    • Lemster B, Huang LL, Irish W, Woo J, Carroll PB, Abu-Elmagd K et al. Influence of FK 506 (tacrolimus) on circulating CD4+ T cells expressing CD25 and CD45RA antigens in 19 patients with chronic progressive multiple sclerosis participating in an open label drug safety trial. Autoimmunity 1995; 19: 89-98.
    • (1995) Autoimmunity , vol.19 , pp. 89-98
    • Lemster, B.1    Huang, L.L.2    Irish, W.3    Woo, J.4    Carroll, P.B.5    Abu-Elmagd, K.6
  • 33
    • 23544477716 scopus 로고    scopus 로고
    • Safety and tolerability of interferon beta-1b in combination with tacrolimus in the treatment of relapsing-remitting multiple sclerosis and SPMS
    • ECTRIMS 19th Congress
    • Jacques F. Safety and tolerability of interferon beta-1b in combination with tacrolimus in the treatment of relapsing-remitting multiple sclerosis and SPMS. ECTRIMS 19th Congress. Mult Scler 2003; 9 (Suppl 1): S95-S96.
    • (2003) Mult Scler , vol.9 , Issue.SUPPL. 1
    • Jacques, F.1
  • 34
    • 0028831965 scopus 로고
    • In vitro and in vivo effects of pentoxifylline on macrophages and lymphocytes derived from autoimmune MRL-lpr/lpr mice
    • Hecht M, Muller M, Lohmann-Matthes ML, Emmendorffer A. In vitro and in vivo effects of pentoxifylline on macrophages and lymphocytes derived from autoimmune MRL-lpr/lpr mice. J Leukoc Biol 1995; 57: 242-249.
    • (1995) J Leukoc Biol , vol.57 , pp. 242-249
    • Hecht, M.1    Muller, M.2    Lohmann-Matthes, M.L.3    Emmendorffer, A.4
  • 35
    • 0035110543 scopus 로고    scopus 로고
    • Antidiabetogenic effect of pentoxifylline is associated with systemic and target tissue modulation of cytokines and nitric oxide production
    • Stosic-Grujicic S, Maksimovic D, Badovinac V, Samardzic T, Trajkovic V, Lukic M et al. Antidiabetogenic effect of pentoxifylline is associated with systemic and target tissue modulation of cytokines and nitric oxide production. J Autoimmun 2001; 16: 47-58.
    • (2001) J Autoimmun , vol.16 , pp. 47-58
    • Stosic-Grujicic, S.1    Maksimovic, D.2    Badovinac, V.3    Samardzic, T.4    Trajkovic, V.5    Lukic, M.6
  • 36
    • 0031902917 scopus 로고    scopus 로고
    • Synergistic immunomodulatory effects of interferon-beta 1b and the phosphodiesterase inhibitor pentoxifylline in patients with relapsing-remitting multiple sclerosis
    • Weber F, Polak T, Gunther A, Kubuschok B, Janovskaja J, Bitsch A et al. Synergistic immunomodulatory effects of interferon-beta 1b and the phosphodiesterase inhibitor pentoxifylline in patients with relapsing-remitting multiple sclerosis. Ann Neurol 1998; 44: 27-34.
    • (1998) Ann Neurol , vol.44 , pp. 27-34
    • Weber, F.1    Polak, T.2    Gunther, A.3    Kubuschok, B.4    Janovskaja, J.5    Bitsch, A.6
  • 37
    • 0031920180 scopus 로고    scopus 로고
    • All-trans retinoic acid potentials the ability of interferon beta-1b to augment suppressor cell function in multiple sclerosis
    • Qu ZX, Dayal A, Jensen MA, Arnason BG. All-trans retinoic acid potentials the ability of interferon beta-1b to augment suppressor cell function in multiple sclerosis. Arch Neurol 1998; 55: 315-321.
    • (1998) Arch Neurol , vol.55 , pp. 315-321
    • Qu, Z.X.1    Dayal, A.2    Jensen, M.A.3    Arnason, B.G.4
  • 38
    • 0034694108 scopus 로고    scopus 로고
    • Effects of repeated fluoxetine and citalopram administration on cytokine release in C57BL/6 mice
    • Kubera M, Simbirtsev A, Mathison R, Maes M. Effects of repeated fluoxetine and citalopram administration on cytokine release in C57BL/6 mice. Psychiatry Res 2000; 96: 255-266.
    • (2000) Psychiatry Res , vol.96 , pp. 255-266
    • Kubera, M.1    Simbirtsev, A.2    Mathison, R.3    Maes, M.4
  • 39
    • 0035801768 scopus 로고    scopus 로고
    • Increased percentage of IL-12+ monocytes in the blood correlates with the presence of active MRI lesions in MS
    • Makhlouf K, Weiner HL. Increased percentage of IL-12+ monocytes in the blood correlates with the presence of active MRI lesions in MS. J Neuroimmunol 2001; 119: 145-149.
    • (2001) J Neuroimmunol , vol.119 , pp. 145-149
    • Makhlouf, K.1    Weiner, H.L.2
  • 41
    • 3042766902 scopus 로고    scopus 로고
    • Combination therapy of MS patients with incomplete response to interferon-beta with humanized antibody against the interleukin-2 receptor alpha chain
    • ACTRIMS 7th Annual Meeting, ECTRIMS 18th Congress
    • Bielekova B, Reichert-Scrivner S, Wuerfel J, Ohayon J, McCartin J, Richert N et al. Combination therapy of MS patients with incomplete response to interferon-beta with humanized antibody against the interleukin-2 receptor alpha chain. ACTRIMS 7th Annual Meeting, ECTRIMS 18th Congress. Mult Scler 2002; 8 (Suppl 1): S4.
    • (2002) Mult Scler , vol.8 , Issue.SUPPL. 1
    • Bielekova, B.1    Reichert-Scrivner, S.2    Wuerfel, J.3    Ohayon, J.4    McCartin, J.5    Richert, N.6
  • 43
    • 3042851299 scopus 로고    scopus 로고
    • Safety, pharmacokinetic (PK), and pharmacodynamic (PD) drug interaction study of antegren and interferon beta-1A (IFNβ-1a, Avonex) in patients with relapsing remitting multiple sclerosis
    • ECTRIMS 16th Congress
    • Vollmer T, Phillips JT, Goodman A, Agius M, Shah J, Gross J. Safety, pharmacokinetic (PK), and pharmacodynamic (PD) drug interaction study of antegren and interferon beta-1A (IFNβ-1a, Avonex) in patients with relapsing remitting multiple sclerosis. ECTRIMS 16th Congress. Rev Neurol 2000; 156 (Suppl 3): S127.
    • (2000) Rev Neurol , vol.156 , Issue.SUPPL. 3
    • Vollmer, T.1    Phillips, J.T.2    Goodman, A.3    Agius, M.4    Shah, J.5    Gross, J.6
  • 44
    • 3042770118 scopus 로고    scopus 로고
    • Baseline patient characteristics of the SENTINEL study: A study designed to determine the efficacy and safety of natalizumab (Antegren) in combination with interferon beta-1a (Avonex) for the treatment of relapsing-remitting multiple sclerosis (RRMS)
    • ECTRIMS 19th Congress
    • Rudick R, Calabresi P, Confavreux C, Galetta S, Hartung HP, Radu EW et al. Baseline patient characteristics of the SENTINEL study: a study designed to determine the efficacy and safety of natalizumab (Antegren) in combination with interferon beta-1a (Avonex) for the treatment of relapsing-remitting multiple sclerosis (RRMS). ECTRIMS 19th Congress. Mult Scler 2003; 9 (Suppl 1): S141-142.
    • (2003) Mult Scler , vol.9 , Issue.SUPPL. 1
    • Rudick, R.1    Calabresi, P.2    Confavreux, C.3    Galetta, S.4    Hartung, H.P.5    Radu, E.W.6
  • 45
    • 23544469093 scopus 로고    scopus 로고
    • Steroids, ibuprofen and acetaminophen for flu-like symptoms induced by intramuscular interferon beta-1a in relapsing-remitting multiple sclerosis
    • ECTRIMS 19th Congress
    • Rio J, Bonaventura I, Arroyo R, Genis D, Sureda B, Ara JR et al. Steroids, ibuprofen and acetaminophen for flu-like symptoms induced by intramuscular interferon beta-1a in relapsing-remitting multiple sclerosis. ECTRIMS 19th Congress. Mult Scler 2003; 9 (Suppl 1): S26.
    • (2003) Mult Scler , vol.9 , Issue.SUPPL. 1
    • Rio, J.1    Bonaventura, I.2    Arroyo, R.3    Genis, D.4    Sureda, B.5    Ara, J.R.6
  • 46
    • 0037330509 scopus 로고    scopus 로고
    • Effects of combination therapy of beta-interferon 1a and prednisone on serum immunologic markers in patients with multiple sclerosis
    • Salama HH, Kolar OJ, Zang YC, Zhang J. Effects of combination therapy of beta-interferon 1a and prednisone on serum immunologic markers in patients with multiple sclerosis. Mult Scler 2003; 9: 28-31.
    • (2003) Mult Scler , vol.9 , pp. 28-31
    • Salama, H.H.1    Kolar, O.J.2    Zang, Y.C.3    Zhang, J.4
  • 47
    • 0036158851 scopus 로고    scopus 로고
    • Monthly corticosteroids decrease neutralizing antibodies to IFN beta 1b: A randomized trial in multiple sclerosis
    • Pozzilli C, Antonini G, Bagnato F, Mainero C, Tomassini V, Onesti E et al. Monthly corticosteroids decrease neutralizing antibodies to IFN beta 1b: a randomized trial in multiple sclerosis. J Neurol 2002; 249: 50-56.
    • (2002) J Neurol , vol.249 , pp. 50-56
    • Pozzilli, C.1    Antonini, G.2    Bagnato, F.3    Mainero, C.4    Tomassini, V.5    Onesti, E.6
  • 48
    • 23544432433 scopus 로고    scopus 로고
    • Association of beta-interferon and inosine in relapsing-remitting multiple sclerosis
    • ECTRIMS 19th Congress
    • Gonsette RE, D'hooghe BD, De Deyn P, Decoo D, Dupuis M, Guillaume D et al. Association of beta-interferon and inosine in relapsing-remitting multiple sclerosis. ECTRIMS 19th Congress. Mult Scler 2003; 9 (Suppl 1): S141.
    • (2003) Mult Scler , vol.9 , Issue.SUPPL. 1
    • Gonsette, R.E.1    D'Hooghe, B.D.2    De Deyn, P.3    Decoo, D.4    Dupuis, M.5    Guillaume, D.6
  • 49
    • 0033924730 scopus 로고    scopus 로고
    • The neuroprotective effects of (-) deprenyl in the gerbil hippocampus following transient global ischemia
    • Kuhmonen J, Jolkkonen J, Haapalinna A, Sivenius J. The neuroprotective effects of (-) deprenyl in the gerbil hippocampus following transient global ischemia. J Neural Transm 2000; 107: 779-786.
    • (2000) J Neural Transm , vol.107 , pp. 779-786
    • Kuhmonen, J.1    Jolkkonen, J.2    Haapalinna, A.3    Sivenius, J.4
  • 50
    • 23544463713 scopus 로고    scopus 로고
    • Open-label safety study of combining selegeline with glatiramer acetate in patients with multiple sclerosis: Neuroprotection by combining immunomodulation and genetic modulation
    • ECTRIMS 19th Congress
    • Caen C, Din M, Khan O. Open-label safety study of combining selegeline with glatiramer acetate in patients with multiple sclerosis: neuroprotection by combining immunomodulation and genetic modulation. ECTRIMS 19th Congress. Mult Scler 2003; 9 (Suppl 1): S141.
    • (2003) Mult Scler , vol.9 , Issue.SUPPL. 1
    • Caen, C.1    Din, M.2    Khan, O.3
  • 51
    • 0031966055 scopus 로고    scopus 로고
    • Toxicity in a double-blind, placebo-controlled pilot trial with D-penicillamine and metacycline in secondary progressive multiple sclerosis
    • Dubois B, D'hooghe MB, De Lepeleire K, Ketelaer P, Opdenakker G, Carton H. Toxicity in a double-blind, placebo-controlled pilot trial with D-penicillamine and metacycline in secondary progressive multiple sclerosis. Mult Scler 1998; 4: 74-78.
    • (1998) Mult Scler , vol.4 , pp. 74-78
    • Dubois, B.1    D'Hooghe, M.B.2    De Lepeleire, K.3    Ketelaer, P.4    Opdenakker, G.5    Carton, H.6
  • 52
    • 0032804203 scopus 로고    scopus 로고
    • Long-term open-trial of mizoribine with prednisolone in 24 patients with multiple sclerosis: Safety, clinical and magnetic resonance imaging outcome
    • Saida K, Zhigang Z, Ozawa K, Konishi T, Saida T. Long-term open-trial of mizoribine with prednisolone in 24 patients with multiple sclerosis: safety, clinical and magnetic resonance imaging outcome. Intern Med 1999; 38: 636-642.
    • (1999) Intern Med , vol.38 , pp. 636-642
    • Saida, K.1    Zhigang, Z.2    Ozawa, K.3    Konishi, T.4    Saida, T.5
  • 53
    • 0031968661 scopus 로고    scopus 로고
    • Combined immunoglobulin and azathioprine in multiple sclerosis
    • Kalanie H, Tabatabai SS. Combined immunoglobulin and azathioprine in multiple sclerosis. Eur Neurol 1998; 39: 178-181.
    • (1998) Eur Neurol , vol.39 , pp. 178-181
    • Kalanie, H.1    Tabatabai, S.S.2
  • 54
    • 23544448054 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled study of intravenous immune globulins (IVIG) in combination with intravenous methylprednisolone (MP) in the treatment of relapses in patients with multiple sclerosis (MS)
    • ACTRIMS 7th Annual Meeting, ECTRIMS 18th Congress
    • Visser LH, Beekman R, Tijssen CC, Uitdehaag BM, Movig C, Lenderink B. A randomized, double-blind, placebo-controlled study of intravenous immune globulins (IVIG) in combination with intravenous methylprednisolone (MP) in the treatment of relapses in patients with multiple sclerosis (MS). ACTRIMS 7th Annual Meeting, ECTRIMS 18th Congress. Mult Scler 2002; 8 (Suppl 1): S118.
    • (2002) Mult Scler , vol.8 , Issue.SUPPL. 1
    • Visser, L.H.1    Beekman, R.2    Tijssen, C.C.3    Uitdehaag, B.M.4    Movig, C.5    Lenderink, B.6
  • 55
    • 23544445335 scopus 로고    scopus 로고
    • Intravenous immunoglobulins as add-on treatment to methylprednisolone for acute relapses in multiple sclerosis
    • ECTRIMS 19th Congress
    • Soelberg Sorensen P, Haas J, Sellebjerg F, Olsson T, Ravnborg, TARIMS Study Group. Intravenous immunoglobulins as add-on treatment to methylprednisolone for acute relapses in multiple sclerosis. ECTRIMS 19th Congress. Mult Scler 2003; 9 (Suppl 1): S26.
    • (2003) Mult Scler , vol.9 , Issue.SUPPL. 1
    • Soelberg Sorensen, P.1    Haas, J.2    Sellebjerg, F.3    Olsson, T.4    Ravnborg5
  • 56
    • 23544447363 scopus 로고    scopus 로고
    • Combination therapy with glatiramer acetate (GA) and intravenous methylprednisolone (IVMP) in relapsing-remitting multiple sclerosis (RRMS) patients at high risk of secondary progression
    • ECTRIMS 17th Congress
    • Caon C, Zwartau-Hind M, Din M, Tselis A, Lisak R, Khan O. Combination therapy with glatiramer acetate (GA) and intravenous methylprednisolone (IVMP) in relapsing-remitting multiple sclerosis (RRMS) patients at high risk of secondary progression. ECTRIMS 17th Congress. Mult Scler 2001; 7 (Suppl 1): S58.
    • (2001) Mult Scler , vol.7 , Issue.SUPPL. 1
    • Caon, C.1    Zwartau-Hind, M.2    Din, M.3    Tselis, A.4    Lisak, R.5    Khan, O.6
  • 57
    • 23544435490 scopus 로고    scopus 로고
    • Inducing and maintaining remission in aggressive relapsing-remitting multiple sclerosis: Experience of sequential treatment with mitoxantrone and glatiramer acetate
    • ECTRIMS 19th Congress
    • Jacob A, McCoy K, Boggild MD. Inducing and maintaining remission in aggressive relapsing-remitting multiple sclerosis: experience of sequential treatment with mitoxantrone and glatiramer acetate. ECTRIMS 19th Congress. Mult Scler 2003; 9 (Suppl 1): S18.
    • (2003) Mult Scler , vol.9 , Issue.SUPPL. 1
    • Jacob, A.1    McCoy, K.2    Boggild, M.D.3
  • 59
    • 0035030236 scopus 로고    scopus 로고
    • Combined treatment with corticosteroids and moclobemide favors normalization of hypothalamo-pituitary-adrenal axis dysregulation in relapsing-remitting multiple sclerosis: A randomized, double blind trial
    • Then Bergh F, Kumpfel T, Grasser A, Rupprecht R, Holsboer F, Trenkwalder C. Combined treatment with corticosteroids and moclobemide favors normalization of hypothalamo-pituitary-adrenal axis dysregulation in relapsing-remitting multiple sclerosis: a randomized, double blind trial. J Clin Endocrinol Metab 2001; 86: 1610-1615.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 1610-1615
    • Then Bergh, F.1    Kumpfel, T.2    Grasser, A.3    Rupprecht, R.4    Holsboer, F.5    Trenkwalder, C.6
  • 61
    • 3042851300 scopus 로고    scopus 로고
    • A randomized study of low fat diet with ω-3 fatty acid supplementation in patients with relapsing-remitting multiple sclerosis
    • AAN 55th Annual Meeting
    • Weinstock-Guttman B, Baier M, Feichter J, Gallagher E, Vekatraman J, Meksawan K et al. A randomized study of low fat diet with ω-3 fatty acid supplementation in patients with relapsing-remitting multiple sclerosis. AAN 55th Annual Meeting. Neurology 2003; 60 (Suppl 1) A151.
    • (2003) Neurology , vol.60 , Issue.SUPPL. 1
    • Weinstock-Guttman, B.1    Baier, M.2    Feichter, J.3    Gallagher, E.4    Vekatraman, J.5    Meksawan, K.6
  • 62
    • 0027521002 scopus 로고
    • Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. II. MRI analysis results of a multicenter, randomized, double-blind, placebo-controlled trial
    • UBC MS/MRI Study Group and IFNB Multiple Sclerosis Study Group
    • Paty DW, Li DKB. Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. II. MRI analysis results of a multicenter, randomized, double-blind, placebo-controlled trial. UBC MS/MRI Study Group and IFNB Multiple Sclerosis Study Group. Neurology 1993; 43: 662-667.
    • (1993) Neurology , vol.43 , pp. 662-667
    • Paty, D.W.1    Li, D.K.B.2
  • 63
    • 0030816046 scopus 로고    scopus 로고
    • New treatments and azathioprine in multiple sclerosis
    • Palace J, Rothwell P. New treatments and azathioprine in multiple sclerosis. Lancet 1997; 350: 261.
    • (1997) Lancet , vol.350 , pp. 261
    • Palace, J.1    Rothwell, P.2
  • 64
    • 0029934518 scopus 로고    scopus 로고
    • Risk of cancer from azathioprine therapy in multiple sclerosis: A case-control study
    • Confavreux C, Saddier P, Grimaud J, Moreau T, Adeleine P. Risk of cancer from azathioprine therapy in multiple sclerosis: A case-control study. Neurology 1996; 46: 1607-1612.
    • (1996) Neurology , vol.46 , pp. 1607-1612
    • Confavreux, C.1    Saddier, P.2    Grimaud, J.3    Moreau, T.4    Adeleine, P.5
  • 65
    • 1842831735 scopus 로고    scopus 로고
    • Induction treatment with mitoxantrone in worsening relapsing remitting multiple sclerosis: A 'rescue therapy' for sub-optimal responders to interferon beta? A pilot study
    • AAN 55th Annual Meeting
    • Le Page E, Leray E, Debouverie M, Pelletier J, Malikova I, Clanet M et al. Induction treatment with mitoxantrone in worsening relapsing remitting multiple sclerosis: a 'rescue therapy' for sub-optimal responders to interferon beta? A pilot study. AAN 55th Annual Meeting. Neurology 2003; 60 (Suppl 1): A149.
    • (2003) Neurology , vol.60 , Issue.SUPPL. 1
    • Le Page, E.1    Leray, E.2    Debouverie, M.3    Pelletier, J.4    Malikova, I.5    Clanet, M.6
  • 66
    • 23544477456 scopus 로고    scopus 로고
    • Mitoxantrone in multiple sclerosis patients non-responders to beta interferon
    • ECTRIMS 19th Congress
    • Tellez N, Pericot I, Rovira A, Galan I, Arevalo MJ, Porcel J et al. Mitoxantrone in multiple sclerosis patients non-responders to beta interferon. ECTRIMS 19th Congress. Mult Scler 2003; 9 (Suppl 1): S79.
    • (2003) Mult Scler , vol.9 , Issue.SUPPL. 1
    • Tellez, N.1    Pericot, I.2    Rovira, A.3    Galan, I.4    Arevalo, M.J.5    Porcel, J.6
  • 67
    • 23544462078 scopus 로고    scopus 로고
    • Retrospective study of multiple sclerosis patients who received mitoxantrone in combination with interferon beta and/or IV solumedrol
    • ECTRIMS 19th Congress
    • Jacques F, Carignan MJ, Dumais N, Halle D. Retrospective study of multiple sclerosis patients who received mitoxantrone in combination with interferon beta and/or IV solumedrol. ECTRIMS 19th Congress. Mult Scler 2003; 9 (Suppl 1): S121.
    • (2003) Mult Scler , vol.9 , Issue.SUPPL. 1
    • Jacques, F.1    Carignan, M.J.2    Dumais, N.3    Halle, D.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.