Autoantibodies against granulocyte-macrophage colony stimulating factor and interleukin-3 are rare in patients with Felty's syndrome

Annals of the Rheumatic Diseases

Volumn 63, Issue 7, 2004, Pages 862-866

  Hellmich, B ^a,b   Ciaglo, A ^b   Schatz, H ^b   Coakley, G ^c,d  

^a UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^b RUHR UNIVERSITY BOCHUM   (Germany)

^c KING'S COLLEGE LONDON   (United Kingdom)

^d QUEEN ELIZABETH HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 3; NEUTRALIZING ANTIBODY;

ADULT; ARTICLE; BIOASSAY; CELL LINE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOPENIA; ENZYME LINKED IMMUNOSORBENT ASSAY; FELTY SYNDROME; FEMALE; HUMAN; IN VITRO STUDY; MALE; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; STATISTICAL SIGNIFICANCE;

AUTOANTIBODIES; CASE-CONTROL STUDIES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FELTY'S SYNDROME; FEMALE; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HUMANS; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; INTERLEUKIN-3; MALE; MIDDLE AGED;

EID: 3042785881     PISSN: 00034967     EISSN: None     Source Type: Journal    
DOI: 10.1136/ard.2003.011056     Document Type: Article

References (26)

1. Campion G, Maddison PJ, Goulding N, James I, Ahren MJ, Watt I, et al. The Felty syndrome: a case-matched study of clinical manifestations and outcome, serologic features and immunogenetic associations. Medicine 1990;69:69-80.
2. Starkebaum G, Singer J, Arend WP. Humoral and cellular immune mechanisms of neutropenia in patients with Felty's syndrome. Clin Exp Immunol 1980;39:307-14.
3. Coakley G, Iqbal M, Brooks D, Panayi G, Lanchbury J. CD8+, CD57+ T-cells from healthy elderly subjects suppress neutrophil development in vitro: implications for the neutropenia in Felty's and large granular lymphocyte syndromes. Arthritis Rheum 2000;43:834-43.
4. Abdou N. Heterogeneity of bone-marrow directed immune mechanisms in the pathogenesis of neutropenia in Felty's syndrome. Arthritis Rheum 1983;26:947-53.
5. Goldberg L, Bacon P, Bucknall R, Fitchen J, Cline M. Inhibition of human bone marrow-granulocyte precursors by serum from patients with Felty's syndrome. J Rheumatol 1980;7:275-8.
6. Gupta R, LaForce F, Mills D. Polymorphonuclear leukocyte inclusions and impaired bacterial killing in patients with Felty's syndrome. J Lab Clin Med 1976;88:183-93.
7. Hellmich B, Csernok E, Schatz H, Gross WL, Schnabel A. Autoantibodies against granulocyte colony-stimulating factor in Felty's syndrome and neutropenic systemic lupus erythematosus. Arthritis Rheum 2002;46:2384-91.
8. Bagley CJ, Woodcock JM, Stomski FC, Lopez AF. The structural and functional basis of cytokine receptor activation: lessons from the common beta subunit of the granulocyte-macrophage colony-stimulating factor, interleukin-3 (IL-3), and IL-5 receptors. Blood 1997;89:1471-82.
9. Geijsen N, Koenderman L, Coffer PJ. Specificity in cytokine signal transduction: lessons learned from the IL-3/IL-5/GM-CSF receptor family. Cytokine Growth Factor Rev 2001;12:19-25.
10. Ragnhammar P, Friesen H, Frødin J, Lefvert A, Hassan M, Østerborg A, et al. Induction of anti-recombinant human granulocyte-macrophage colony- stimulating factor (Escherichia coli-derived) antibodies and clinical effects in non-immunocompromised patients. Blood 1994;84:4078-87.
11. Meager A, Wadhwa M, Bird C, Dilger P, Thorpe R, Newsom-Davis, et al. Spontaneously occurring neutralizing antibodies against granulocyte- macrophage colony-stimulating factor in patients with autoimmune disease. Immunology 1999;97:526-32.
12. Kitamura T, Tanaka N, Watnabe J, Uchida K, Kanegasaki S, Yamada Y, et al. Idiopathic pulmonary aveolar proteinosis as an autoimmune disease with neutralizing antibody against granulocyte/macrophage colony-stimulating factor. J Exp Med 1999;190:875-80.
13. Casadevall N, Nataf J, Viron B, Kolta A, Kiladjian J-J, Martin-Dupont P, et al. Pure red-cell aplasi and antierythropoietin antibodies in patients treated with recombinant reythropoietin. N Engl J Med 2002;346:469-75.
14. Tzioufas A, Kokori S, Petrovas C, Moutsopulos H. Autoantibodies to human recombinant erythropoietin in patients with systemic lupus erythematosus. Arthritis Rheum 1997;40:2212-16.
15. Arnett FC, Edworthy SM, Bloch DA, Mc Shane DJ, Fries JF, Cooper NS, et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1987;31:315-24.
16. Coakley G, Brooks D, Iqbal, Kondeatis E, Vaughan R, Loughran T, et al. Major histocompatility complex haplotypic associations in Felty's syndrome and large granular lymphocyte syndrome are secondary to allelic association with HLA-DRB1*0401. Rheumatology 2000;39:393-8.
17. Svenson M, Herbrink P. Measurement of cytokine antibodies. Test development. Biotherapy 1997;10:87-92.
18. Svenson M, Hansen M, Ross C, Diamant M, Rieneck K, Nielsen H, et al. Antibody to granulocyte-macrophage colony-stimulating factor is a dominant anti-cytokine activity in human IgG preparations. Blood 1998;91:2054-61.
19. Revoltella R. Natural and therapeutically induced antibodies to cytokines. Biotherapy 1998;10:321-31.
20. Revoltella R, Laricchia-Robbio L, Moscato S, Genua A, Liberati A. Natural and therapy-induced anti-GM-CSF and anti-G-CSF antibodies in human serum. Leukemia Lymphoma 1997;26(Suppl 1):29-34.
21. Hellmich B, Csernok E, de Haas M, von dem Borne AE, Schatz H, Gross WL, et al. Low Fc-gamma receptor III and high granulocyte colony-stimulating factor serum levels correlate with risk of infection in neutropenia due to Felty's syndrome or systemic lupus erythematosus. Am J Med 2002;113:134-9.
22. Omori F, Okamura S, Shimoda K, Otsuka T, Harada M, Niho Y. Levels of human serum granulocyte colony-stimulating factor and granulocyte- macrophage colony-stimulating factor under pathological conditions. Biotherapy 1992;4:147-53.
23. van Gils F, Westerman Y, Visser T, Burger H, van Leen R, Wagemaker G. Neutralizing antibodies during treatment of homologous nonglycosylated IL-3 in rhesus monkeys. Leukemia 1994;8:648-51.
24. Suzuki H, Takemura H, Yoshizaji K, Koishihara Y, Ohsugi Y, Okano A, et al. IL-6-anti-IL-6 autoantibody complexes with IL-6 activity in sera from some patients with systemic sclerosis. J Immunol 1994;152:935-42.
25. Caruso A, Turano A. Natural antibodies to interferon-gamma. Biotherapy 1997;10:29-37.
26. Caruso A, Bonfanti C, Colombrita D, De Francesco M, De Rango C, Foresti I, et al. Natural antibodies to IFN-gamma in man and their increase during viral infection. J Immunol 1990;144:685-90.