Hindsight rather than foresight: Reality versus the EU draft guideline on pharmaceuticals in the environment

Trends in Biotechnology

Volumn 22, Issue 7, 2004, Pages 326-330

  O'Brien, Evelyn ^a   Dietrich, Daniel R ^a  

^a UNIVERSITY OF KONSTANZ   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

COSTS; INLAND WATERWAYS; POLLUTION; SEWAGE TREATMENT; WASTEWATER; WATER TREATMENT PLANTS;

EUROPEAN UNION (EU); SEWAGE TREATMENT PLANTS (STP);

DRUG PRODUCTS;

CHEMICAL COMPOUND; HORMONE; WATER;

AQUATIC ENVIRONMENT; COST EFFECTIVENESS ANALYSIS; ENDOCRINOLOGY; ENVIRONMENTAL FACTOR; EUROPE; FINANCE; HUMAN; INDUSTRY; LAKE; NONHUMAN; POLLUTANT; PRACTICE GUIDELINE; PREDICTION; PRIORITY JOURNAL; QUALITY CONTROL; REVIEW; RISK ASSESSMENT; RIVER; SEWAGE TREATMENT PLANT; TIME; WASTE WATER MANAGEMENT;

ANIMALIA;

EID: 3042779538     PISSN: 01677799     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tibtech.2004.05.003     Document Type: Article

References (28)

1. EEA. Environment in the European Union at the Turn of the Century. 1999;European Environment Agency, Copenhagen
2. EMEA (2003) Draft Note for Guidance on Environmental Risk Assessment of Medicinal Products for Human Use (CPMP/SWP/4447/00), pp. 1-22, European Agency for the Evaluation of Medical Products.
3. Brooks B.W., et al. Aquatic ecotoxicology of fluoxetine. Toxicol. Lett. 142:2003;169-183
4. Lange R., et al. Effects of the synthetic estrogen 17α- ethinylestradiol on the life-cycle of the fathead minnow (Pimephales promelas). Environ. Toxicol. Chem. 20:2001;1216-1227
5. Ahel M., et al. Behaviour of alkylphenol polyethoxylate surfactant in the aquatic environment. I. Occurrence and transformation in sewage treatment. Water Res. 28:1994;1131-1142
6. Jobling S., et al. Widespread sexual disruption in wild fish. Environ. Sci. Technol. 32:1998;2498-2506
7. Korner W., et al. Input/output balance of estrogenic active compounds in a major municipal sewage plant in Germany. Chemosphere. 40:2000;1131-1142
8. Tanghe T., et al. Nonylphenol and estrogenic activity in aquatic environmental samples. J. Environ. Qual. 28:1999;702-709
9. Ternes T., et al. Behaviour and occurrence of estrogens in municipal sewage treatment plants. I. Investigations in Germany, Canada and Brazil. Sci. Total Environ. 225:1999;81-90
10. Kuch H., Ballschmiter K. Determination of endogenous and exogenous estrogens in effluent from sewage treatment plants at the ng/L-level. Fresenius J. Anal. Chem. 366:2000;392-395
11. van der Aerle R., et al. Sexual disruption in a second species of wild cyprinid fish (the gudgeon, Gobio gobio) in UK fresh waters. Environ. Toxicol. Chem. 20:2001;2841-2847
12. Jobling S., et al. Altered sexual maturation and gamete production in wild roach (Rutilus rutilus) living in rivers that receive treated sewage effluents. Biol. Reprod. 66:2002;272-281
13. Pickering A., Sumpter J.P. Comprehending endocrine disrupters in aquatic environments. Environ. Sci. Technol. 37:2003;331A-336A
14. Desbrow C., et al. Identification of estrogenic chemicals in STW effluent. I. Chemical fractionation and in vitro biological screening. Environ. Sci. Technol. 32:1998;1549-1558
15. Lee H.B., Peart T.E. Determination of 17β-estradiol and its metabolites in sewage effluent by solid-phase extraction and gas chromatography/mass spectrometry. J. AOAC Int. 81:(6):1998;1209-1216
16. Belfroid A.C., et al. Analysis and occurrence of estrogenic hormones and their glucuronides in surface water and waste water in The Netherlands. Sci. Total Environ. 225:1999;101-108
17. Rodgers-Gray T.P., et al. Long-term temporal changes in the estrogenic composition of treated sewage effluent and its biological effects on fish. Environ. Sci. Technol. 34:2000;1521-1528
18. Ayscough N.J., et al. Review of Human Pharmaceuticals in the Environment: Technical Report. 2000;Bristol Environmental Agency
19. Webb S.F. A data-based perspective on the environmental risk assessment of human pharmaceuticals. II. Aquatic risk characterisation. Kümmerer K. Pharmaceuticals in the Environment: Sources, Fate, Effects and Risks. 2001;204-219 Springer-Verlag
20. Kümmerer K. Introduction: pharmaceuticals in the environment. Kümmerer K. Pharmaceuticals in the Environment: Sources, Fate, Effects and Risk. 2001;1-8 Springer-Verlag
21. Hutchinson T.H., et al. A strategy to reduce the numbers of fish used in acute ecotoxicity testing of pharmaceuticals. Environ. Toxicol. Chem. 22:2003;3031-3036
22. Balk F., Ford R.A. Environmental risk assessment for the polycyclic musks, AHTN and HHCB in the EU. I. Fate and exposure assessment. Toxicol. Lett. 111:1999;81-94
23. Dietrich D.R., Hitzfeld B.C. Bioaccumulation and ecotoxicology of synthetic musks in the aquatic environment. Hutzinger O. The Handbook of Environmental Chemistry. Vol. 3:2004;233-244 Springer-Verlag
24. Webb S.F. A data-based perspective on the environmental risk assessment of human pharmaceuticals. I. Collation of available ecotoxicity data. Kümmerer K. Pharmaceuticals in the Environment: Sources, Fate, Effects and Risks. 2001;175-201 Springer-Verlag
25. Jones O.A.H., et al. Aquatic environmental assessment of the top 25 English prescription pharmaceuticals. Water Res. 36:2002;5013-5022
26. Kirk L.A., et al. Changes in estrogenic and androgenic activities at different stages of treatment in wastewater treatment works. Environ. Toxicol. Chem. 21:2002;972-979
27. Heberer T. Occurrence, fate and removal of pharmaceutical residues in the aquatic environment: a review of recent research data. Toxicol. Lett. 131:2002;5-17
28. Jeckel M. Full-scale applications. Gottschalk C., et al. Ozonation of Water and Waste Water. 2000;21-36 Wiley-VCH Verlag