The effect of Sinomenine on cyclooxygenase activity and the expression of COX-1 and COX-2 mRNA in human peripheral monocytes

Zhongguo Zhongyao Zazhi

Volumn 28, Issue 4, 2003, Pages 354-355

  Wang, Wen Jun ^a   Wang, Pei Xun ^a   Li, Xiao Juan ^a  

^a GUANGZHOU UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

COX 1; COX 2; PBMC; PGE2; RT PCR; Sinomenine

Indexed keywords

CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; ISOENZYME; MEMBRANE PROTEIN; MESSENGER RNA; MORPHINAN DERIVATIVE; PROSTAGLANDIN E2; PROSTAGLANDIN SYNTHASE; PTGS1 PROTEIN, HUMAN; PTGS2 PROTEIN, HUMAN; SINOMENINE;

ADULT; ARTICLE; BIOSYNTHESIS; BLOOD; CHEMISTRY; ENZYMOLOGY; HUMAN; ISOLATION AND PURIFICATION; MEDICINAL PLANT; METABOLISM; MONONUCLEAR CELL; SINOMENIUM;

ADULT; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; DINOPROSTONE; HUMANS; ISOENZYMES; LEUKOCYTES, MONONUCLEAR; MEMBRANE PROTEINS; MORPHINANS; PLANTS, MEDICINAL; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RNA, MESSENGER; SINOMENIUM;

EID: 3042778528     PISSN: 10015302     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. I A Tavares, P M Bishai, A Bennett. Activity of Nimesulide on Constitutive and Inducible Cyclooxygenases. Drug Research, 1995, 45(II),(10):1093.
2. 2 and Cyclooxygenase-2 mRNA is Suppressed by Glucocorticoids in Human Epithelial Cells. Life Sciences, 1997, 60(1):67.
3. Liang-ji Zhou, Thomas F Tedder. A Distinct Pattern of Cytokine Gene Expression by Human CD83 + Blood Dendritic Cells. Blood, 1995, 86(9):3295.
4. Mitchell J A, Akarasereenont P, Thiemermann C, et al. Selectivity of Nonsteroidal Antiinflammatory Drugs as Inhibitors of Constitutive and Inducible Cyclooxygenase. Proc Natl Acad Sci, USA, 1994, 90:11693.
5. Donna Slater, Victoria Allport, Phillip Bennett. Changes in the Expression of the Type-2 But Not the Type-1 Cyclooxygenase Enzyme in Choriondecidua with the Onset of Labour. British Journal of Obstetrics and Gynaecology, 1998, 105:745.
6. Keiichi Tanaka, Hiroki Kawasaki, Kiyonobu Kurata, et al. T-614, A Novel Antirheumatic Drug, Inhibits Both the Activity and Induction of Cyclooxygenase-2 (COX-2) in Cultured Fibroblasts. Jpn J Pharmacol, 1995, 67:305.
7. Laufer S, Zechmeister P, Klein T. Development of An In-vitro Test System for the Evaluation of Cyclooxygenase-2 Inhibitors. Inflamm Res, 1999, 48(3):133.
8. Hideki Kamitani, Mark Geller, Thomas Eling. Expression of 15-Lipoxygenase by Human Colorectal Carcinoma Caco-2 Cells During Apoptosis and Cell Differentiation. The Journal of Biological Chemistry, 1998, 273(34):21569.