Accelerated wound healing by in vivo application of keratinocytes overexpressing KGF

Molecular Therapy

Volumn 10, Issue 1, 2004, Pages 86-96

  Kopp, Jürgen ^a   Wang, Guang Y ^b   Kulmburg, Peter ^c   Schultze Mosgau, Stefan ^a   Huan, Jing N ^b   Ying, Kang ^d   Seyhan, Harun ^a   Jeschke, Mark D ^a   Kneser, Ulrich ^a   Bach, Alexander D ^a   Ge, Sheng D ^b   Dooley, Steven ^e   Horch, Raymund E ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

^c F HOFFMANN LA ROCHE LTD   (Switzerland)

^d FUDAN UNIVERSITY   (China)

^e UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Gene transfer techniques; Growth factors; Molecular therapy; Transformed cell line; Transplantation; Wound healing

Indexed keywords

GROWTH FACTOR; KERATINOCYTE GROWTH FACTOR; WOUND HEALING PROMOTING AGENT;

ANIMAL TISSUE; ARTICLE; BURN; CELL IMMORTALIZATION; CELL TRANSPLANTATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DRUG MECHANISM; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITHELIUM; FIBROBLAST; FOLLOW UP; GENE INTERACTION; GENE OVEREXPRESSION; GENETIC ENGINEERING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VIVO STUDY; KERATINOCYTE; MOLECULAR CLONING; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; POLYMERASE CHAIN REACTION; PROTEIN LOCALIZATION; SWINE; TISSUE REGENERATION; TRANSGENE; WOUND HEALING;

ANIMALS; BURNS; CELL LINE; CELL TRANSPLANTATION; EPIDERMIS; FIBROBLAST GROWTH FACTOR 7; FIBROBLAST GROWTH FACTORS; GENE THERAPY; GENETIC VECTORS; HUMANS; KERATINOCYTES; PLASMIDS; SWINE; TRANSFECTION; WOUND HEALING;

EID: 3042773736     PISSN: 15250016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ymthe.2004.04.016     Document Type: Article

References (33)

1. Kanzler M.H. Gorsulowsky D.C. Swanson N.A. Basic mechanisms in the healing cutaneous wound J. Dermatol. Surg. Oncol. 12 1986 1156-1164
2. Steenfos H.H. Growth factors and formation granulation tissue 1992 Göteborg University Göteborg
3. Pessa M.E. Bland K.I. Copeland E.M. III. Growth factors and determinants of wound repair J. Surg. Res. 42 1987 207-217
4. Sporn M.B. Roberts A.B. Peptide growth factors and inflammation, tissue repair, and cancer J. Clin. Invest. 78 1986 329-332
5. Aaronson S.A. et al. Growth factor-regulated pathways in epithelial cell proliferation Am. Rev. Respir. Dis. 142 1990 S7-S10
6. Rubin J.S. et al. Keratinocyte growth factor Cell. Biol. Int. 19 1995 399-411
7. Finch P.W. Lengel C. Chedid M. Cloning and characterization of the promoter region of the human keratinocyte growth factor gene J. Biol. Chem. 270 1995 11230-11237
8. Latkowski J.M. Freedberg I.M. Blumenberg M. Keratinocyte growth factor and keratin gene regulation J. Dermatol. Sci. 9 1995 36-44
9. Sotozono C. Kinoshita S. Kita M. Imanishi J. Paracrine role of keratinocyte growth factor in rabbit corneal epithelial cell growth Exp. Eye Res. 59 1994 385-391
10. Dlugosz A.A. Cheng C. Denning M.F. Dempsey P.J. Coffey R.J. Jr. Yuspa S.H. Keratinocyte growth factor receptor ligands induce transforming growth factor alpha expression and activate the epidermal growth factor receptor signaling pathway in cultured epidermal keratinocytes Cell Growth Differ. 5 1994 1283-1292
11. Kopan R. Traska G. Fuchs E. Retinoids as important regulators of terminal differentiation: examining keratin expression in individual epidermal cells at various stages of keratinization J. Cell Biol. 105 1987 427-440
12. Lin H.C. Piing J.T. Tseng Y.M. Chao C.F. Effect of epidermal growth factor on the sheet formation of the human keratinocyte in cell culture Proc. Natl. Sci. Counc. Repub. China B 12 1988 215-221
13. Choi Y. Fuchs E. TGF-beta and retinoic acid: regulators of growth and modifiers of differentiation in human epidermal cells Cell Regul. 1 1990 791-809
14. Nelson K.G. Takahashi T. Bossert N.L. Walmer D.K. McLachlan J.A. Epidermal growth factor replaces estrogen in the stimulation of female genital-tract growth and differentiation Proc. Natl. Acad. Sci. USA 88 1991 21-25
15. Brown G.L. Curtsinger L. Jurkiewicz M.J. Nahai F. Schultz G. Stimulation of healing of chronic wounds by epidermal growth factor Plast. Reconstr. Surg. 88 1991 189-194 discussion 195-186
16. Boukamp P. Petrussevska R.T. Breitkreutz D. Hornung J. Markham A. Fusenig N.E. Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line J. Cell Biol. 106 1988 761-771
17. Brosin A. Wolf V. Mattheus A. Heise H. Use of XTT-assay to assess the cytotoxicity of different surfactants and metal salts in human keratinocytes (HaCaT). A feasible method for in vitro testing of skin irritants Acta Dermatol. Venereol. 77 1997 26-28
18. Gerlier D. Thomasset N. Use of MTT colorimetric assay to measure cell activation J. Immunol. Methods 94 1986 57-63
19. Kopp J. Bannasch H. Andree C. Stark G.B. Kultivierte Keratinozyten auf einem Silikon-Kollagen-Matrix-Träger zur Deckung von Vollhautdefekten Langenbecks Arch. Chirurgie/Forumband 1996 299-300
20. Kopp J. et al. Membrane cell grafts (MCG), fresh and frozen, to cover full thickness wounds in athymic nude mice Eur. J. Plast. Surg. 22 1999 213-219
21. Witherell G.W. Gil A. Wimmer E. Interaction of polypyrimidine tract binding protein with the encephalomyocarditis virus mRNA internal ribosomal entry site Biochemistry 32 1993 8268-8275
22. Gossen M. Freundlieb S. Bender G. Muller G. Hillen W. Bujard H. Transcriptional activation by tetracyclines in mammalian cells Science 268 1995 1766-1769
23. Kulmburg P. et al. NTS influence on transgene expression from mono- and bicistronic plasmid vectors after lipofection in a human fibroblast cell line J. Mol. Med. 75 1997 223-229
24. Veelken H. et al. Systematic evaluation of chimeric marker genes on dicistronic transcription units for regulated expression of transgenes in vitro and in vivo Hum. Gene Ther. 7 1996 1827-1836
25. Vogt P.M. et al. Dry, moist, and wet skin wound repair Ann. Plast. Surg. 34 1995 493-499 discussion 499-500
26. Grabbe J. et al. Release of stem cell factor from a human keratinocyte line, HaCaT, is increased in differentiating versus proliferating cells J. Invest. Dermatol. 107 1996 219-224
27. Kato M. et al. A human keratinocyte cell line produces two autocrine growth inhibitors, transforming growth factor-beta and insulin-like growth factor binding protein-6, in a calcium- and cell density-dependent manner J. Biol. Chem. 270 1995 12373-12379
28. Steed D.L. Clinical evaluation of recombinant human platelet-derived growth factor for the treatment of lower extremity diabetic ulcers. Diabetic Ulcer Study Group J. Vasc. Surg. 21 1995 71-78 discussion 79-81
29. Pierce G.F. Mustoe T.A. Pharmacologic enhancement of wound healing Annu. Rev. Med. 46 1995 467-481
30. Richard J.L. et al. Effect of topical basic fibroblast growth factor on the healing of chronic diabetic neuropathic ulcer of the foot. A pilot, randomized, double-blind, placebo-controlled study Diabetes Care 18 1995 64-69
31. Rosenthal F.M. et al. Paracrine stimulation of keratinocytes in vitro and continuous delivery of epidermal growth factor to wounds in vivo by genetically modified fibroblasts transfected with a novel chimeric construct In Vivo 11 1997 201-208
32. Boyce S.T. Ham R.G. Calcium-regulated differentiation of normal human epidermal keratinocytes in chemically defined clonal culture and serum-free serial culture J. Invest. Dermatol. 81 1983 33s-40s
33. Roehm N.W. Rodgers G.H. Hatfield S.M. Glasebrook A.L. An improved colorimetric assay for cell proliferation and viability utilizing the tetrazolium salt XTT J. Immunol. Methods 142 1991 257-265