Effects of duration of ischemia and donor pretreatment with methylprednisolone or its macromolecular prodrug on the disposition of indocyanine green in cold-preserved rat livers

Pharmaceutical Research

Volumn 21, Issue 6, 2004, Pages 1000-1008

  Chimalakonda, Anjaneya P ^a   Mehvar, Reza ^a  

^a TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

dextran prodrugs; indocyanine green; ischemia reperfusion; isolated perfused rat liver; methylprednisolone

Indexed keywords

INDOCYANINE GREEN; METHYLPREDNISOLONE; METHYLPREDNISOLONE SODIUM SUCCINATE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CRYOPRESERVATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INDUCED HYPOTHERMIA; KINETICS; LIVER; LIVER METABOLISM; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; REPERFUSION; STATISTICAL SIGNIFICANCE; TISSUE PRESERVATION;

ACID PHOSPHATASE; ALANINE TRANSAMINASE; ANIMALS; ASPARTATE AMINOTRANSFERASES; BILE; CRYOPRESERVATION; DEXTRANS; DRUG COMBINATIONS; INDOCYANINE GREEN; ISCHEMIA; L-LACTATE DEHYDROGENASE; LIVER; LIVER FAILURE; LIVER TRANSPLANTATION; METHYLPREDNISOLONE HEMISUCCINATE; ORGAN PRESERVATION; ORGAN PRESERVATION SOLUTIONS; PERFUSION; PRODRUGS; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; TIME FACTORS; TISSUE DONORS;

EID: 3042769192     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/B:PHAM.0000029290.54167.7c     Document Type: Article

References (32)

1. P. A. Clavien, P. R. Harvey, and S. M. Strasberg. Preservation and reperfusion injuries in liver allografts. An overview and synthesis of current studies. Transplantation 53:957-978 (1992).
2. K. M. Olthoff. Molecular pathways of regeneration and repair after liver transplantation. World J. Surg. 26:831-837 (2002).
3. M. Kukan and P. S. Haddad. Role of hepatocytes and bile duct cells in preservation-reperfusion injury of liver grafts. Liver Transpl. 7:381-400 (2001).
4. J. J. Lemasters and R. G. Thurman. Reperfusion injury after liver preservation for transplantation. Annu. Rev. Pharmacol. Toxicol. 37:327-338 (1997).
5. H. Suzuki and Y. Sugiyama. Transport of drugs across the hepatic sinusoidal membrane: sinusoidal drug influx and efflux in the liver. Semin. Liver Dis. 20:251-263 (2000).
6. C. G. Krenn, B. Schafer, G. A. Berlakovich, R. Steininger, H. Steltzer, and C. K. Spiss. Detection of graft nonfunction after liver transplantation by assessment of indocyanine green kinetics. Anesth. Analg. 87:34-36 (1998).
7. K. I. Bzeizi, R. Jalan, J. N. Plevris, and P. C. Hayes. Primary graft dysfunction after liver transplantation: from pathogenesis to prevention. Liver Transpl. Surg. 3:137-148 (1997).
8. G. A. Kullak-Ublick, B. Hagenbuch, B. Stieger, A. W. Wolkoff, and P. J. Meier. Functional characterization of the basolateral rat liver organic anion transporting polypeptide. Hepatology 20:411-416 (1994).
9. L. Huang and M. Vore. Multidrug resistance p-glycoprotein 2 is essential for the biliary excretion of indocyanine green. Drug Metab. Dispos. 29:634-637 (2001).
10. M. Lund, L. Kang, N. Tygstrup, A. W. Wolkoff, and P. Ott. Effects of LPS on transport of indocyanine green and alanine uptake in perfused rat liver. Am. J. Physiol. 277:G91-100 (1999).
11. S. Iu, P. R. Harvey, L. Makowka, C. N. Petrunka, R. G. Ilson, and S. M. Strasberg. Markers of allograft viability in the rat. Relationship between transplantation viability and liver function in the isolated perfused liver. Transplantation 44:562-569 (1987).
12. A. P. Chimalakonda and R. Mehvar. Attenuation of Kupffer cell activation in cold-preserved livers after pretreatment of rats with methylprednisolone or its macromolecular prodrug. Pharm. Res. 20:1001-1008 (2003).
13. X. Zhang and R. Mehvar. Dextran-methylprednisolone succinate as a prodrug of methylprednisolone: plasma and tissue disposition. J. Pharm. Sci. 90:2078-2087 (2001).
14. A. P. Chimalakonda and R. Mehvar. Dextran-methylprednisolone succinate as a prodrug of methylprednisolone: local immunosuppressive effects in liver after systemic administration to rats. Pharm. Res. 20:198-204 (2003).
15. M. Wang, M. Sakon, K. Umeshita, M. Okuyama, K. Shiozaki, H. Nagano, K. Dohno, S. Nakamori, and M. Monden. Prednisolone suppresses ischemia-reperfusion injury of the rat liver by reducing cytokine production and calpain mu activation. J. Hepatol. 34:278-283 (2001).
16. R. Mehvar. Simultaneous analysis of dextran-methylprednisolone succinate, methylprednisolone succinate, and methylprednisolone by size-exclusion chromatography. J. Pharmaceut. Biomed. Anal. 19:785-792 (1999).
17. D. S. McKindley, C. Chichester, and R. Raymond. Effect of endotoxin shock on the clearance of lidocaine and indocyanine green in the perfused rat liver. Shock 12:468-472 (1999).
18. R. K. Roberts, C. A. Heath, R. F. Johnson, K. V. Speeg Jr., and S. Schenker. Effect of H2-receptor antagonists on steady-state extraction of indocyanine green and lidocaine by the perfused rat liver. J. Lab. Clin. Med. 107:112-117 (1986).
19. P. L. Rappaport and J. J. Thiessen. High-pressure liquid chromatographic analysis of indocyanine green. J. Pharm. Sci. 71:157-161 (1982).
20. C. March, M. H. Adams, W. Garnett, and H. T. Karnes. Stability of indocyanine green in human serum stored at -20 and -70 degrees C. Ther. Drug Monit. 16:588-591 (1994).
21. R. Mehvar. High-performance size-exclusion chromatographic analysis of dextran-methylprednisolone hemisuccinate in rat plasma. J. Chromatogr. B 744:293-298 (2000).
22. R. Mehvar, R. O. Dann, and D. A. Hoganson. Simultaneous analysis of methylprednisolone, methylprednisolone succinate, and endogenous corticosterone in rat plasma. J. Pharmaceut. Biomed. Anal. 22:1015-1022 (2000).
23. K. Pang and M. Rowland. Hepatic clearance of drugs. II. experimental evidence for acceptance of the "well-stirred" model over the "parallel tube" model using lidocaine in the perfused rat liver in situ preparation. J. Pharmacokinet. Biopharm. 5:655-679 (1977).
24. H. Nakano, K. Boudjema, E. Alexandre, P. Imbs, M. P. Chenard, P. Wolf, J. Cinqualbre, and D. Jaeck. Protective effects of N-acetylcysteine on hypothermic ischemia-reperfusion injury of rat liver. Hepatology 22:539-545 (1995).
25. Y. Kumamoto, M. Suematsu, M. Shimazu, Y. Kato, T. Sano, N. Makino, K. I. Hirano, M. Naito, G. Wakabayashi, Y. Ishimura, and M. Kitajima. Kupffer cell-independent acute hepatocellular oxidative stress and decreased bile formation in post-cold-ischemic rat liver. Hepatology 30:1454-1463 (1999).
26. M. Mory, J. Ackemann, W. Gross, M. Schaefer, and M. M. Gebhard. Hepatocellular indocyanine green transport in the isolated reperfused canine liver following UW preservation and cold ischemia. Transplant. Proc. 34:2305-2306 (2002).
27. M. Kukan, S. Bezek, and T. Trnovec. Uptake, reflux, and excretion of bromosulfophthalein in ischaemia-reperfusion injury of rat liver. Physiol. Res. 44:415-419 (1995).
28. H. Shinohara, A. Tanaka, T. Fujimoto, E. Hatano, S. Satoh, K. Fujimoto, T. Noda, C. Ide, and Y. Yamaoka. Disorganization of microtubular network in postischemic liver dysfunction: its functional and morphological changes. Biochim. Biophys. Acta 1317:27-35 (1996).
29. C. Chen, G. E. Hennig, D. J. McCann, and J. E. Manautou. Effects of clofibrate and indocyanine green on the hepatobiliary disposition of acetaminophen and its metabolites in male CD-1 mice. Xenobiotica 30:1019-1032 (2000).
30. K. Sathirakul, H. Suzuki, K. Yasuda, M. Hanano, O. Tagaya, T. Horie, and Y. Sugiyama. Kinetic analysis of hepatobiliary transport of organic anions in Eisai hyperbilirubinemic mutant rats. J. Pharmacol. Exp. Ther. 265:1301-1312 (1993).
31. I. V. Deaciuc, G. J. Bagby, M. R. Niesman, N. Skrepnik, and J. J. Spitzer. Modulation of hepatic sinusoidal endothelial cell function by Kupffer cells: an example of intercellular communication in the liver. Hepatology 19:464-470 (1994).
32. I. V. Deaciuc, G. J. Bagby, C. H. Lang, and J. J. Spitzer. Hyaluronic acid uptake by the isolated, perfused rat liver: an index of hepatic sinusoidal endothelial cell function. Hepatology 17:266-272 (1993).