Glyminox (Biosyn)

Current Opinion in Investigational Drugs

Volumn 5, Issue 2, 2004, Pages 222-231

  Witherell, Gary W ^a  

^a Questcor Pharmaceuticals Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGENTS USED INTRAVAGINALLY; NEW DRUG; SPERMICIDAL AGENT;

ANIMAL; CLINICAL TRIAL; HUMAN; METHODOLOGY; PHARMACEUTICS; REVIEW; SEXUALLY TRANSMITTED DISEASE; STATISTICS;

ANIMALS; CLINICAL TRIALS; DRUGS, INVESTIGATIONAL; HUMANS; SEXUALLY TRANSMITTED DISEASES; SPERMATOCIDAL AGENTS; TECHNOLOGY, PHARMACEUTICAL; VAGINAL CREAMS, FOAMS, AND JELLIES;

EID: 3042764812     PISSN: 14724472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (35)

1. 318058 AVAX Technologies; drug development pipeline. DRUG DEV PIPELINE 1999 4 2
2. 322506 Biosyn Inc initiates second drug trial for Savvy contraceptive and HIV preventive gel. Biosyn Inc PRESS RELEASE 1999 April 23
3. 326346 A broad-spectrum microbicide with virucidal activity against sexually transmitted viruses. Howett MK, Neely EB, Christensen ND, Wigdahl B, Krebs FC, Malamud D, Patrick SD, Pickel MD, Welsh PA, Reed CA, Ward MG et al ANTIMICROB AGENTS CHEMOTHER 1999 43 2 314-321
4. 371801 Biosyn receives Notice of Allowance for key patent addition to C31G technology platform. Biosyn Inc PRESS RELEASE 2000 June 21
5. 371865 Biosyn Inc announces phase I clinical results for Savvy microbicide. Biosyn Inc PRESS RELEASE 2000 June 22
6. 389707 Biosyn announces new data indicating Savvy vaginal microbiocide is highly acceptable formulation among women. Biosyn Inc PRESS RELEASE 2000 November 14
7. 443488 Superbugs and Superdrugs - SMi Conference, Innovations in Anti-Infectives, London, UK. Erlich R IDDB MEETING REPORT 2002 March 6-7
8. 443619 Better Medicines: Prevention and treatment of common infectious diseases. Bax R SMI CONF SUPERBUGS SUPERDRUGS -INNOVATION ANTI-INFECTIVES 2002 3
9. 450939 Biosyn announces positive clinical results of two phase I/II trials for Savvy microbicide gel. Biosyn Inc PRESS RELEASE 2002 May 13
10. 485652 Comparative in vitro sensitivities of human immune cell lines, vaginal and cervical epithelial cell lines, and primary cells to candidate microbicides nonoxynol 9, C31G, and sodium dodecyl sulfate. Krebs FC, Miller S, Catalone BJ, Fichorova R, Anderson D, Malamud D, Howett MK, Wigdahl B ANTIMICROB AGENTS CHEMOTHER 2002 46 7 2292-2298
11. 485655 Sodium dodecyl sulfate and C31G as microbicidal alternatives to nonoxynol 9: Comparative sensitivity of primary human vaginal keratinocytes. Krebs FC, Miller SR, Catalone BJ, Welsh PA, Malamud D, Howett MK, Wigdahl B ANTIMICROB AGENTS CHEMOTHER 2000 44 7 1954-1960
12. 485657 The microbicidal agent C31G inhibits Chlamydia trachomatis infectivity in vitro. Wyrick PB, Knight ST, Gerbig DG Jr, Raulston JE, Davis CH, Paul TR, Malamud D ANTIMICROB AGENTS CHEMOTHER 1997 41 6 1335-1344
13. 485658 Effect of suppository bases on the release properties of a potent antimicrobial agent (C31G). Calis S, Sumnu M, Hincal AA PHARMAZIE 1994 49 5 336-339
14. 485659 A non-antibiotic antimicrobial mixture (C31G): Evaluation of the antimicrobial efficiency of C31G on vaginal cultures. Calis S, Yulug N, Sumnu M, Ayhan A, Hincal AA BOLL CHIM FARM 1992 131 9 335-338
15. 485661 Safety of single daily use for one week of C31G HEC gel in women. Ballagh SA, Baker JM, Henry DM, Archer DF CONTRACEPTION 2002 66 5 369-375
16. 485698 Mice and rabbit models for oral and percutaneous absorption and disposition of amphoteric surfactant C31G. Michaels EB, Hahn EC, Kenyon AJ AM J VET RES 1983 44 10 1977-1983
17. 485702 C31G, a new agent for oral use with potent antimicrobial and antiadherence properties. Corner AM, Dolan MM, Yankell SL, Malamud D ANTIMICROB AGENTS CHEMOTHER 1988 32 3 350-353
18. 502833 Assessment of the anti-microbial agent C31G as a spermicide: Comparison with nonoxynol-9. Thompson KA, Malamud D, Storey BT CONTRACEPTION 1996 53 5 313-318
19. 513631 FDA grants Fast Track designation for 1.0% C31G vaginal gel for the reduction of HIV transmission. Biosyn Inc PRESS RELEASE 2003 November 17
20. 515249 Council calls for guidance on spermicide use. AIDS ALERT 1996 11 3 27-30
21. 515252 Microbicides in HIV prevention. McCormack S, Hayes R, Lacey CJ, Johnson AM BMJ 2001 322 7283 410-413
22. 515254 Microbicides - evaluating multiple formulations of C31G. Bax R, Douville K, McCormick D, Rosenberg M, Higgins J, Bowden M CONTRACEPTION 2002 66 5 365-368
23. 515257 Inactivation of human immunodeficiency virus type 1 by nonoxynol-9, C31G, or an alkyl sulfate, sodium dodecyl sulfate. Krebs FC, Miller SR, Malamud D, Howett MK, Wigdahl B ANTIVIRAL RES 1999 43 3 157-173
24. 515264 Effects of multiple applications of benzalkonium chloride and nonoxynol 9 on the vaginal epithelium in the pigtailed macaque (Macaca nemestrina). Patton DL, Kidder GG, Sweeney YC, Rabe LK, Hillier SL AM J OBSTET GYNECOL 1999 180 5 1080-1087
25. 515268 Controlled wound repair in guinea pigs, using antimicrobials that alter fibroplasias. Kenyon AJ, Hamilton SG, Douglas DM AM J VET RES 1986 47 1 96-101
26. 515269 Effect of C31G, an antimicrobial surfactant, on healing of incised guinea pig wounds. Michaels EB, Hahn EC, Kenyon AJ AM J VET RES 1983 44 7 1378-1381
27. 515271 A burned mouse model to evaluate anti-Pseudomonas activity of topical agents. Stieritz DD, Bondi A, McDermott D, Michaels ED J ANTIMICROB CHEMOTHER 1982 9 2 133-140
28. 515994 Biosyn. COMPANY WORLD WIDE WEB SITE 2003 December 04
29. 516000 The amfAR treatment insider: Microbicides - a neglected line of defense. Epstein H, The American Foundation for AIDS Research INTERNET SITE 2000 1 1 2-4 http://www.amfar.org/
30. 516004 amfAR global link: Nonoxynol-9 (N-9) and its effectiveness in preventing HIV transmission. Gayle H, The American Foundation for AIDS Research INTERNET SITE 2003 http://www.amfar.org/
31. 516025 Microbicides to prevent heterosexual transmission of HIV: Ten years down the road. van de Wijgert J, Coggins C BETA 2002 15 2 23-28
32. 516422 Microbicides: Putting women in control. Forbes A WORLD 1998 89 4-5
33. 516433 Formulation of C31G as a vaginal microbicide. Malamud D, Schnaare RL In: VAGINAL MICROBICIDE FORMULATIONS WORKSHOP Rencher WF Jr (Ed) Lippincott-Raven, Philadelphia, PA, USA 1998 79-89
34. 519043 POZ - inside: The jelly revolution. Schwartz D, The Body INTERNET SITE 2000 1-8 http://www.thebody.com
35. 519218 About microbicides - clinical testing. Global Campaign for Microbicides INTERNET SITE 2004 January 15 http://www.global-campaign. org