Synthesis of tetrahydronaphthyl thioureas as potent appetite suppressants

Bioorganic and Medicinal Chemistry

Volumn 12, Issue 15, 2004, Pages 4189-4196

  Bhandari, Kalpana ^a   Srivastava, Shipra ^a   Shankar, Girija ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

Author keywords

Appetite suppressants; Synthesis; Thiourea

Indexed keywords

1 AMINO 2 HYDROXYTETRAHYDRONAPHTHALENE; 1 AMINOTETRALIN; 1,2,3,4 TETRAHYDRONAPHTHALEN 1 YL 2 (4 FLUOROPHENYLPIPERAZINE) 1 CARBOTHIOAMIDE; 2 HYDROXY 1,2,3,4 TETRAHYDRONAPHTHALEN 1 YL 2 (3 CHLOROPHENYLPIPERAZINE) 1 CARBOTHIAMIDE; 2 HYDROXY 1,2,3,4 TETRAHYDRONAPHTHALEN 1 YL 2 (3ALPHA,ALPHA,ALPHA TRIFLUOROMETHYLPHENYLPIPERAZINE) 1 CARBOTHIOAMIDE; 2 HYDROXY 1,2,3,4 TETRAHYDRONAPHTHALEN 1 YL 2 (4 FLUOROPHENYLPIPERAZINE) 1 CARBOTHIOAMIDE; 2 HYDROXY 1,2,3,4 TETRAHYDRONAPHTHALEN 1 YL 2 (4 METHYLPIPERAZINE) 1 CARBOTHIAMIDE; 2 HYDROXY 1,2,3,4 TETRAHYDRONAPHTHALEN 1 YL 2 (4 PHENYLPIPERAZINE) 1 CARBOTHIOAMIDE; 2 HYDROXY 1,2,3,4 TETRAHYDRONAPHTHALEN 1 YL 2 (4 TOLYLPIPERAZINE) 1 CARBOTHIOAMIDE; 2 HYDROXY 1,2,3,4 TETRAHYDRONAPHTHALEN 1 YL 2 [4 (2 PYRIDYL)PIPERAZINE] 1 CARBOTHIOAMIDE; 2 HYDROXY 1,2,3,4 TETRAHYDRONAPHTHALEN 1 YL 2 PYRROLIDINE 1 CARBOTHIOAMIDE; ANOREXIGENIC AGENT; N (1,2,3,4 TETRAHYDRONAPHTHALEN 1 YL)THIOUREA; N (2 HYDROXY 1,2,3,4 TETRAHYDRONAPHTHALEN 1 YL)THIOUREA; N (2 PHENYLETHYL) N' (1,2,3,4 TETRAHYDRONAPHTHALEN 1 YL)THIOUREA; N (2 PHENYLETHYL) N' (2 HYDROXY 1,2,3,4 TETRAHYDRONAPHTHALEN 1 YL)THIOUREA; N (4 METHYLCYCLOHEX 1 YL) N' (2 HYDROXY 1,2,3,4 TETRAHYDRONAPHTHALEN 1 YL)THIOUREA; N BENZOYL N' (2 HYDROXY 1,2,3,4 TETRAHYDRONAPHTHALEN 1 YL)THIOUREA; N BENZYL N METHYL N' (1,2,3,4 TETRAHYDRONAPHTHALEN 1 YL)THIOUREA; N BENZYL N METHYL N' (2 HYDROXY 1,2,3,4 TETRAHYDRONAPHTHALEN 1 YL)THIOUREA; N CYCLOHEXYL N' (1,2,3,4 TETRAHYDRONAPHTHALEN 1 YL)THIOUREA; N CYCLOHEXYL N' (2 HYDROXY 1,2,3,4 TETRAHYDRONAPHTHALEN 1 YL)THIOUREA; N PHENYL N' (2 HYDROXY 1,2,3,4 TETRAHYDRONAPHTHALEN 1 YL)THIOUREA; NAPHTHALENE DERIVATIVE; THIOUREA DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; MALE; MOUSE; NONHUMAN; STRUCTURE ANALYSIS;

ANIMALS; APPETITE DEPRESSANTS; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; FEEDING BEHAVIOR; FEMALE; MALE; MICE; MOLECULAR STRUCTURE; THIOUREA;

EID: 3042759476     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.05.039     Document Type: Article

References (22)

1. Hyattsville M.D. National Center for Health Statistics. Health E-Stats. 2000
2. Flegal K.M., Carroll M.D., Ogden C.L., Johnson C.L. JAMA. 288:2002;1723-1727
3. Bray, G. A. In Nutrition, Endocrinology, and Diseases; Bray, G. A., Ryan, D. H., Eds.; Pennington Center Nutrition Series; Lousiana State University Press: Baton Rouge, 1995; Vol. 4, pp 131-176
4. Atkinson R.L. Annu. Rev. Nutr. 17:1997;383-403
5. Triscari J., Tilley J., Hogan S. Annu. Rep. Med. Chem. 23:1988;191-200
6. Garattini S., Bizzi A., Codegoni A.M., Mennini T. Am. J. Clin. Nutr. 55:1992;160S-166S
7. Kennett G.A. Drugs. 1:1998;456-470
8. Malone M. Drugs. 1:1998;232-235
9. Daniel W.L., Matthew C.L., Marina R.A., Patricia G. Drugs of the Future. 26(9):2001;873-881
10. Connoley I.P., Frost I., Heal D.J., Stock M.J. Br. J. Pharmacol. 117:1996;170
11. Bray G.A. Rev. Endocrine Metab. Disord. 2(4):2001;403-418
12. Hauner H. Int. J. Obes. 25(Suppl. 1):2001;S102-S106
13. King D.J., Devaney N. Br. J. Pharmacol. 26:1988;607-611
14. Drent M.L., Larsson I., Oisson J.W., Quaade F., Czubayko F., Bergmann K.V., Strobel W., Sjostrom L., Veen E.A.V. Int. J. Obes. Relat. Metab. Disord. 19:1995;221
15. Jackson, J. L. U.S. Patent 3,985,898, 1976; Chem. Abstr. 1977, 86, 434-444
16. Hewett, C. L.; Savage, D. S.; Redpath, J.; Sleigh, T.; Rae, D. R. Ger. Patent 2,618,721, 1976; Chem. Abstr. 1977, 86, 89479
17. Maillard, J. G. Ger. Patent 2,422,879, 1975; Chem. Abstr. 1975, 82, 155958
18. Bhandari K., Sharma V.L., Singh C.M., Shanker G., Singh H.K. Ind. J. Chem. 39B:2000;468-471
19. Shukla U.K., Singh R., Khanna J.M., Saxena A.K., Singh H.K., Sur R.N., Dhawan B.N., Anand N. Collect. Czech. Chem. Commun. 57:1992;415-424
20. Delegado A., Garcia J.M., Mauleon D., Minguillon C., Subirats J.R. Can. J. Chem. 66:1988;517-527
21. Bellucci C.M., Bergamini A., Cozzi P.G., Papa A., Tagliavini E., Ronchi A.U. Tetrahedron: Asymmetry. 8(6):1997;895-902
22. Dua, P.R. UNESCO-CDRI Workshop on the use of pharmacological techniques for the study of natural products, held at CDRI, Lucknow, India, 1992; p 130