An experimental model for the study of transient lower oesophageal sphincter relaxation and motor function of the proximal stomach in humans

Neurogastroenterology and Motility

Volumn 16, Issue 3, 2004, Pages 287-292

  Carmagnola, S ^a   Cantu P ^a   Savojardo, D ^a   Allocca, M ^a   Penagini, R ^a  

^a FONDAZIONE IRCCS CA GRANDA OSPEDALE MAGGIORE POLICLINICO   (Italy)

Author keywords

Barostat; Esophageal motility; Gastric motility; Gastric tone; Gastroesophageal reflux disease; Lower oesophageal sphincter

Indexed keywords

ADULT; ARTICLE; BAROSTAT; CONTROLLED STUDY; ESOPHAGUS MOTILITY; EXPERIMENTAL MODEL; FEMALE; GASTROESOPHAGEAL REFLUX; HUMAN; MALE; MEASUREMENT; MOTOR PERFORMANCE; PRIORITY JOURNAL; STOMACH; STOMACH DISEASE; STOMACH DISTENSION; STOMACH MOTILITY;

ADULT; ESOPHAGOGASTRIC JUNCTION; FEMALE; GASTROINTESTINAL MOTILITY; HUMANS; MALE; MANOMETRY; MODELS, BIOLOGICAL; MUSCLE RELAXATION; MUSCLE, SMOOTH; STOMACH;

EID: 3042749641     PISSN: 13501925     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2982.2004.00496.x     Document Type: Article

References (31)

1. Chiba N, De Gara CJ, Wilkinson JM, Hunt RH. Speed of healing and symptoms relief in grade II to IV gastroesophageal reflux disease: a meta-analysis. Gastroenterology 1997; 112: 1798-810.
2. Jones R, Bytzer P. Review article: acid suppression in the management of gastro-oesophageal reflux disease - an appraisal of treatment options in primary care. Aliment Pharmacol Ther 2001; 15: 765-72.
3. Dent J, Dodds W, Friedman R et al. Mechanism of gastroesophageal reflux in recumbent asymptomatic human subjects. J Clin Invest 1980; 65: 256-67.
4. Dodds W, Dent W, Hogan W et al. Mechanisms of gastroesophageal reflux in patients with reflux esophagitis. N Engl J Med 1982; 307: 1547-52.
5. Mittal R, Holloway R, Penagini R, Blackshaw L, Dent J. Transient lower esophageal sphincter relaxation. Gastroenterology 1995; 109: 601-10.
6. Holloway RH. Treatment of gastro-oesophageal reflux disease through control of transient lower oesophageal sphincter relaxations - feasibility, practicality and possibilities. Dig Liver Dis 2000; 32: 183-7.
7. Hirsch DP, Tytgat GNJ, Boeckxstaens GEE. Review article: transient lower oesophageal sphincter relaxations - a pharmacological target for gastro-oesophageal reflux disease? Aliment Pharmacol Ther 2002; 16: 17-26.
8. Holloway RH, Kocyan P, Dent J. Provocation of transient lower esophageal sphincter relaxations by meals in patients with symptomatic gastroesophageal reflux. Dig Dis Sci 1991; 36: 1034-9.
9. Penagini R, Bartesaghi B, Conte D, Bianchi P. Rate of transient lower oesophageal sphincter relaxations of healthy humans after eating a mixed nutrient meal: time course and comparison with fasting. Eur J Gastroenterol Hepatol 1992; 4: 35-38.
10. Wyman JB, Dent J, Heddle R, Dodds WJ, Toouli J, Downton J. Control of belching by the lower oesophageal sphincter. Gut 1990; 31: 639-46.
11. Holloway RH, Hongo M, Berger K, McCallum RW. Gastric distension: a mechanism for postprandial gastroesophageal reflux. Gastroenterology 1985; 89: 779-84.
12. Holloway R, Penagini R, Ireland A. Criteria for objective definition of transient lower esophageal sphincter relaxation. Am J Physiol 1995; 268: G128-33.
13. Tack J, Sifrim D. A little rest and relaxation. Gut 2000; 47: 11-12.
14. Boulant J, Mathieu S, D'Amato M, Abergel A, Dapoigny M, Bommelaer G. Cholecystokinin in transient lower oesophageal sphincter relaxation due to gastric distension in humans. Gut 1997; 40: 575-81.
15. Allocca M, Mangano M, Penagini R. Effect of prolonged gastric distension on motor function of LES and of proximal stomach. Am J Physiol 2002; 283: G677-80.
16. Penagini R, Schoeman M, Tippett M, Holloway R. Motor event underlying gastroesophageal reflux in ambulant patients with reflux oesophagitis. Neurogastroenterol Motil 1996; 8: 131-41.
17. Notivol R, Coffin B, Azpiroz F, Mearin F, Serra J, Malagelada JR. Gastric tone determines the sensitivity of the stomach to distension. Gastroenterology 1995; 108: 330-6.
18. Carmagnola S, Cantù P, Allocca M, Bianchi PA, Penagini R. Tension receptors in the proximal stomach: are they relevant to riggering of transient lower esophageal sphincter relaxation? Gastroenterology 2001; 120: A137.
19. Cantù P, Carmagnola S, Savojardo D, Mangano M, Bianchi PA, Penagini R. Morphine and transient lower esophageal sphincter relaxation: relevance of fundic mechanoreceptors. Gastroenterology 2003; 124: A227.
20. Altman DG. Practical Statistics for Medical Research. London: Chapman & Hall, 1991.
21. Mittal RK, Holloway RH. Effect of atropine on the frequency of reflux and transient lower esophageal sphincter relaxation in normal subjects. Gastroenterology 1995; 109: 1547-54.
22. Clavé P, Gonzales A, Moreno A et al. Endogenous cholecystokinin enhances postprandial gastroesophageal reflux in humans through extrasphincteric receptors. Gastroenterology 1998; 115: 597-604.
23. Lidums I, Lehmann A, Checklin H, Dent J, Holloway R. Control of transient lower esophageal sphincter relaxations and reflux by the GABA agonist baclofen in normal subjects. Gastroenterology 2000; 118: 7-13.
24. Lidums I, Hebbard GS, Holloway RH. Effect of atropine on proximal gastric motor and sensory function in normal subjects. Gut 2000; 47: 30-36.
25. Lee KJ, Vos R, Janssens J, Tack J. Differential effects of baclofen on lower oesophageal sphincter pressure and proximal gastric motility in humans. Aliment Pharmacol Ther 2003; 18: 199-207.
26. Hirsch DP, Holloway RH, Tytgat GNJ, Boeckxstaens GEE. Involvement of nitric oxide in human transient lower esophageal sphincter relaxations and esophageal primary peristalsis. Gastroenterology 1998; 115: 1374-80.
27. Scheffer RCH, Tatum RP, Shi G, Akkermans LMA, Joehl RJ, Kahrilas PJ. Reduced tLESR elicitation in response to gastric distension in fundoplication patients. Am J Physiol 2003; 284: G815-20.
28. Zerbib F, Bruley Des Varannes S, Scarpignato C et al. Endogenous cholecystokinin in postprandial lower esophageal sphincter function and fundic tone in humans. Am J Physiol 1998; 275: G1266-73.
29. Dent J, Holloway RH, Toouli J, Dodds WJ. Mechanisms of lower oesophageal sphincter incompetence in patients with symptomatic gastroesophageal reflux. Gut 1988; 29: 1020-8.
30. Van Herwaarden MA, Samson M, Smout AJPM. Excess gastroesophageal reflux in patients with hiatus hernia is caused by mechanism other than transient LES relaxations. Gastroenterology 2000; 119: 1439-46.
31. Penagini R, Hebbard GS, Horowitz M et al. Motor function of the proximal stomach and visceral perception in gastrooesophageal reflux disease. Gut 1998; 42: 251-7.