Biodistribution and pharmacokinetics of variously molecular sized 117mSn(II)-polyethyleneiminomethyl phosphonate complexes in the normal primate model as potential selective therapeutic bone agents

Arzneimittel-Forschung/Drug Research

Volumn 54, Issue 6, 2004, Pages 340-347

  Zeevaart, Jan R ^a   Louw, Werner K A ^a   Kolar, Zvonimir I ^b   Kilian, Elmaré ^c   Jansen Van Rensburg, Frederika E ^c   Dormehl, Irene C ^c  

^a NECSA   (South Africa)

^b DELFT UNIVERSITY OF TECHNOLOGY   (Netherlands)

^c UNIVERSITY OF PRETORIA   (South Africa)

Author keywords

Bone therapeutics; Polyethyleneiminomethyl phosphonate, 117mSn (II) labelled; Polymer, enhanced permeability and retention effect

Indexed keywords

POLYETHYLENEIMINOMETHYLPHOSPHONATE; RADIOISOTOPE; TIN 117M; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BABOON; BONE CANCER; BONE MARROW TOXICITY; BONE TUMOR; CALCULATION; ENERGY; MALE; MOLECULE; NONHUMAN; PLASMA; PRIMATE;

EID: 3042745550     PISSN: 00044172     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0031-1296981     Document Type: Article

References (19)

1. Volkert, W. A., Hoffman, T. J., Therapeutic radiopharmaceuticals. Chem. Rev. 99, 2269 (1999)
2. Ercan, M. T., Caglar, M., Therapeutic radiopharmaceuticals. Curr. Pharm. Design 6, 1085 (2000)
3. Kratz, F., Schütte, M. T., Anticancer metal complexes and tumour targeting strategies. Cancer J. 11, 60 (1998)
4. Maeda, H., Wu, J., Sawa, T. et al., Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review. J. Controlled Release 65, 271 (2000)
5. Seymour, L. W., Passive tumor targeting of soluble macromolecules and drug conjugates. Crit. Rev. Ther. Drug Carrier Systems 9, 135 (1992)
6. Zeevaart, J. R., Jarvis, N. V., Louw, W. K. A. et al., Metalion speciation in blood plasma incorporating the tetraphosphonate, N,N-dimethylenephosphonate-1-hydroxy-4-aminopropilydenediphosphonate (APDDMP), in therapeutic radiopharmaceuticals. J. Inorg. Biochem. 83, 57 (2001)
7. Jarvis, N. V., Zeevaart, J. R., Wagener, J. M. et al., Metalion speciation in blood plasma incorporating the water-soluble polymer, polyethyleneimine functionalised with methylenephosphonate groups, in therapeutic radiopharmaceuticals. Radiochim. Acta 90, 237 (2002)
8. Dormehl, I. C., Louw, W. K. A., Milner, R. J. et al., Biodistribution and Pharmacokinetics of variously sized molecular radiolabelled polyethyleneiminomethyl phosphonic acid as a selective bone seeker for therapy in the normal primate model. Arzneim.-Forsch./Drug Res. 51 (I), 258 (2001)
9. Dormehl, I. C., Schneeweiss, F. H. A., Louw, W. K. A. et al., Optimalisation of radiolabelled polymin-MP of different molecular sizes as a selective bone seeker for therapy in animal models. Proceedings of the Medical Radiation Physics and Engineering Conference (MeRPE 2000), Lisbon, Portugal, Nov. 2000
10. 117mSn(II)-PEI- MP. J. Radioanal. Nucl. Chem. 257, 83 (2003)
11. 166Ho. J. Chem. Soc. Dalton Trans. 1411 (1995)
12. Atkins, H. L., Mausner, L. F., Srivastava, S. C. et al., Tin117m(4+)-DTPA for palliation of pain from osseous metastases: a pilot study. J. Nucl. Med. 36, 725 (1995)
13. Bouchet, L. G., Bolch, W. E., Goddu, S. M. et al., Considerations in the selection of radiopharmaceuticals for palliation of bone pain from metastatic osseous lesions. J. Nucl. Med. 41, 682 (2000)
14. Louw, W. K. A., Dormehl, I. C., van Rensburg, A. J. et al., Evaluation of Sm-153 and Ho-166-EDTMP in the normal baboon model. Nucl. Med. Biol. 23, 935 (1996)
15. Peters, A. M., Jamar, F., The importance of endothelium and interstitial fluid in nuclear medicine. Eur. J. Nucl. Med. 25, 801 (1998)
16. Saha, G.B., Fundamentals of nuclear pharmacy, pp. 118-119, Springer Verlag, New York (1997)
17. Claessens, R. A. M. J., Kolar, Z. I., Affinity of tin(II) and tin(II) diphosphonates for hydroxyapatite: an experimental and model study. Langmuir 16, 1360 (2000)
18. Zeevaart, J. R., Metal-ion speciation in blood plasma as a tool in predicting the in vivo behaviour of potential bone-seeking radiopharmaceuticals. PhD thesis, pp. 153-156, Delft University Press, Delft (2001)
19. 32P during rat tibial bone repair. J. Nucl. Med. 34, 104 (1993)