Which SSRI? A meta-analysis of pharmacotherapy trials in pediatric obsessive-compulsive disorder

American Journal of Psychiatry

Volumn 160, Issue 11, 2003, Pages 1919-1928

  Geller, Daniel A ^a   Biederman, Joseph ^b   Stewart, S Evelyn ^b   Mullin, Benjamin ^b   Martin, Andrés ^b   Spencer, Thomas ^b   Faraone, Stephen V ^b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CLOMIPRAMINE; FLUOXETINE; FLUVOXAMINE; PAROXETINE; SEROTONIN UPTAKE INHIBITOR; SERTRALINE;

CLINICAL TRIAL; DRUG EFFICACY; HUMAN; META ANALYSIS; OBSESSIVE COMPULSIVE DISORDER; PRIORITY JOURNAL; PSYCHOPHARMACOTHERAPY; REVIEW; TREATMENT OUTCOME;

ADOLESCENT; AGE FACTORS; CHILD; CLOMIPRAMINE; HUMANS; OBSESSIVE-COMPULSIVE DISORDER; PERSONALITY INVENTORY; PLACEBOS; PSYCHIATRIC STATUS RATING SCALES; RANDOMIZED CONTROLLED TRIALS; SEROTONIN UPTAKE INHIBITORS; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME;

EID: 3042740077     PISSN: 0002953X     EISSN: None     Source Type: Journal    
DOI: 10.1176/appi.ajp.160.11.1919     Document Type: Review

References (34)

1. March JS, Biederman J, Wolkow R, Safferman A, Mardekian J, Cook EH, Cutler NR, Dominguez R, Ferguson J, Muller B, Riesenberg R, Rosenthal M, Sallee FR, Wagner KD: Sertraline in children and adolescents with obsessive-compulsive disorder: a multicenter randomized control trial. JAMA 1998; 280:1752-1756
2. Riddle MA, Reeve EA, Yaryura-Tobias JA, Yang HM, Claghorn JL, Gaffney G, Greist JH, Holland D, McConville BJ, Pigott T, Walkup JT: Fluvoxamine for children and adolescents with obsessive-compulsive disorder a randomized, controlled, multicenter trial. J Am Acad Child Adolesc Psychiatry 2001; 40:222-229
3. Geller DA, Hoog SL, Heiligenstein JH, Ricardi RK, Tamura R, Kluszynski S, Jacobsen JG: Fluoxetine treatment for obsessive-compulsive disorder in children and adolescents: a placebo-controlled clinical trial. J Am Acad Child Adolesc Psychiatry 2001; 40:773-779
4. Geller DA, Wagner KD, Emslie GJ, Murphy TK, Gallagher D, Gardiner C, Carpenter DJ: Efficacy of paroxetine in pediatric OCD: results of a multicenter study, in 2002 Annual Meeting New Research Program and Abstracts. Washington, DC, American Psychiatric Association, 2002, number 349
5. Piccinelli M, Pini S, Bellantuono C, Wilkinson G: Efficacy of drug treatment in obsessive-compulsive disorder: a meta-analytic review. Br J Psychiatry 1995; 166.424-443
6. Ackerman DL, Greenland S: Multivariate meta-analysis of controlled drug studies for obsessive-compulsive disorder. J Clin Psychopharmacol 2002; 22:309-317
7. Thase ME: Studying new antidepressants if there were a light at the end of the tunnel, could we see it? J Clin Psychiatry 2002; 63(suppl 2):24-28
8. Scahill L, Riddle M, McSwiggin-Hardin M, Ort SI, King RA, Goodman WK, Cicchetti D, Leckman JF: Children's Yale-Brown Obsessive Compulsive Scale: reliability and validity. J Am Acad Child Adolesc Psychiatry 1997; 36:844-852
9. Leonard HL, Swedo SE, Lenane MC, Rettew DC, Cheslow DL, Hamburger SD, Rapoport JL: A double-blind desipramine substitution during long-term clomipramine treatment in children and adolescents with obsessive-compulsive disorder. Arch Gen Psychiatry 1991; 48:922-927
10. Riddle M, Scahill L, King R, Hardin M, Andersen G, Ort S, Smith J, Leckman J, Cohen D: Double-blind, crossover trial of fluoxetine and placebo in children and adolescents with obsessive-compulsive disorder. J Am Acad Child Adolesc Psychiatry 1992; 31:1062-1069
11. Vitiello B: Psychopharmacology for young children: clinical needs and research opportunities. Pediatrics 2001, 108:983-989
12. Vitiello B: Clinical trials methodology and design issues, in Pediatric Psychopharmacology. Edited by Martin A, Scahill L, Charney DS, Leckman JF. New York, Oxford University Press, 2002, pp 712-724
13. Scahill L, Riddle MA, King RA, Hardin MT, Rasmussen A, Makuch RW, Leckman JF: Fluoxetine has no marked effect on tic symptoms in patients with Tourette's syndrome: a double-blind placebo-controlled study. J Am Acad Child Adolesc Psychiatry 1997; 7:75-85
14. Kurlan R, Deeley C, McDermott M: A pilot controlled study of fluoxetine for obsessive-compulsive symptoms in children with Tourette's syndrome. Clin Neuropharmacol 1993; 16:167-172
15. Goodman WK, Price LH: Assessment of severity and change in obsessive compulsive disorder. Psychiatr Clin North Am 1992; 15:861-869
16. Guy W (ed): ECDEU Assessment Manual for Psychopharmacology: Publication ADM 76-338. Washington. DC, US Department of Health, Education, and Welfare, 1976, pp 218-222
17. Berg CJ, Rapoport JL, Flament M: The Leyton Obsessional inventory - Child Version. J Am Acad Child Adolesc Psychiatry 1986, 25:84-91
18. DeVeaugh-Geiss J, Moroz G, Biederman JB, Cantwell D, Fontaine R, Greist J, Reichler R, Katz R, Landau P: Clomipramine hydrochloride in childhood and adolescent obsessive-compulsive disorder: a multicenter trial. J Am Acad Child Adolesc Psychiatry 1992; 31:45-49
19. DerSimonian R, Laird N: Meta-analysis in clinical trials. Control Clin Trials 1986; 7:177-188
20. Egger M, Smith G, Schneider M, Minder C: Bias in meta-analysis detected by a simple graphical test. Br Med J 1997; 315:629-634
21. Cooper HM, Rosenthal R: Statistical versus traditional procedures for summarizing research findings. Psychol Bull 1980; 87:442-449
22. Liebowitz MR, Turner SM, Piacentini J, Beidel DC, Clarvit SR, Davies SO, Graae F, Jaffer M, Lin SH, Sallee FR, Schmidt AB, Simpson HB: Fluoxetine in children and adolescents with OCD: a placebo-controlled trial J Am Acad Child Adolesc Psychiatry 2002, 41:1431-1438
23. Geller DA, Biederman J, Stewart SE, Mullin B, Farrell C, Wagner KD, Emslie GJ, Carpenter DJ: Impact of comorbidity on treatment response to paroxetine in pediatric obsessive-compulsive disorder, is the use of exclusion criteria empirically supported in randomized clinical trials? J Child Adolesc Psychopharmacol 2003; 13(suppl1):S19-S29
24. March JS, Johnston H, Jefferson JW, Kobak KA, Greist JH: Do subtle neurological impairments predict treatment resistance to clomipramine in children and adolescents with obsessive-compulsive disorder. J Child Adolesc Psychopharmacol 1990; 1:133-140
25. Leonard H, Swedo S, Rapoport J, Koby E, Lenane M, Cheslow D, Hamburger S: Treatment of obsessive-compulsive disorder with clomipramine and desipramine in children and adolescents. Arch Gen Psychiatry 1989; 46:1088-1092
26. Flament MF, Rapoport JL, Berg CJ, Sceery W, Kilts C, Mellstrom B, Linnoila M: Clomipramine treatment of childhood obsessive-compulsive disorder: a double-blind controlled study. Arch Gen Psychiatry 1985; 42:977-983
27. McDougle CJ, Goodman WK, Leckman JF, Barr LC, Heninger GR, Price LH: The efficacy of fluvoxamine in obsessive-compulsive disorder effects of comorbid chronic tic disorder J Clin Psychopharmacol 1993; 13:354-358
28. Peterson BS, Pine DS, Cohen P, Brook JS: Prospective, longitudinal study of tic, obsessive-compulsive, and attention-deficit/hyperactivity disorders in an epidemiological sample. J Am Acad Child Adolesc Psychiatry 2001; 40:685-695
29. Biederman J: Sudden death in children treated with a tricyclic antidepressant: a commentary. J Am Acad Child Adolesc Psychiatry 1991; 30:495-497
30. Puig-Antich J, Perel JM, Lupatkin W, Chambers WJ, Shea C, Tabrizi M, Stiller RL: Plasma levels of imipramine (IMI) and desmethylimipramine (DMI) and clinical response in prepubertal major depressive disorder. J Am Acad Child Psychiatry 1979; 18:616-627
31. Puig-Antich J, Perel JM, Lupatkin W, Chambers WJ, Tabrizi MA, King J, Goetz R, Davies M, Stiller RL: Imipramine in prepubertal major depressive disorders. Arch Gen Psychiatry 1987; 44:81-89
32. Biederman J, Baidessarini R, Wright V, Knee D, Harmatz J: A double-blind placebo controlled study of desipramine in the treatment of attention deficit disorder, I: efficacy. J Am Acad Child Adolesc Psychiatry 1989; 28.777-784
33. Spencer T, Biederman J, Kerman K, Steingard R, Wilens T: Desipramine treatment of children with attention deficit hyperactivity disorder and tic disorder or Tourette's syndrome J Am Acad Child Adolesc Psychiatry 1993; 32:354-360
34. Geller D, Spencer T: Obsessive-compulsive disorder, in Pediatric Psychopharmacology: Principles and Practice. Edited by Martin A, Scahill L, Charney D, Leckman JF. New York, Oxford University Press, 2002, pp 511-525