The 5-HT2B receptor: A main cardio-pulmonary target of serotonin;Le récepteur 5-HT2B: Une cible privilégiée de la sérotonine au niveau cardio-pulmonaire

Journal de la Societe de Biologie

Volumn 198, Issue 1, 2004, Pages 22-29

  Etienne, Nelly ^a   Schaerlinger, Bérénice ^a   Jaffré, Fabrice ^a   Maroteaux, Luc ^a  

^a INSTITUT DE GÉNÉTIQUE ET DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

FENFLURAMINE; PANCREATIC ELASTASE; SEROTONIN; SEROTONIN 2B RECEPTOR; TGFB1 PROTEIN, HUMAN; TGFB1 PROTEIN, MOUSE; TGFB1 PROTEIN, RAT; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1;

ADULT; ANIMAL; ANOXIA; ANTIBODY SPECIFICITY; CELL SURVIVAL; CONGENITAL HEART MALFORMATION; CONGESTIVE CARDIOMYOPATHY; CYTOLOGY; DRUG EFFECT; FETUS HEART; GENETIC PREDISPOSITION; GENETICS; HEART MUSCLE CELL; HUMAN; HYPERTENSION; LETHAL GENE; METABOLISM; MOUSE; MOUSE MUTANT; PATHOLOGY; PHYSIOLOGY; PRENATAL DEVELOPMENT; PULMONARY ARTERY; PULMONARY HYPERTENSION; RAT; REVIEW; TRANSGENIC MOUSE; VASCULAR SMOOTH MUSCLE;

ADULT; ANIMALS; ANOXIA; CARDIOMYOPATHY, DILATED; CELL SURVIVAL; FENFLURAMINE; FETAL HEART; GENES, LETHAL; GENETIC PREDISPOSITION TO DISEASE; HEART DEFECTS, CONGENITAL; HUMANS; HYPERTENSION; HYPERTENSION, PULMONARY; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, CARDIAC; ORGAN SPECIFICITY; PANCREATIC ELASTASE; PULMONARY ARTERY; RATS; RECEPTOR, SEROTONIN, 5-HT2B; SEROTONIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1;

EID: 3042721506     PISSN: 12950661     EISSN: None     Source Type: Journal    
DOI: 10.1051/jbio/2004198010022     Document Type: Article

References (32)

1. 2 receptor subtypes: a family re-united? Trends Pharmacol. Sci., 1995, 16. 105-110.
2. 2C receptors. Br. J. Pharmacol., 1995, 115, 622-628.'
3. 1D receptors. FEBS Lett., 1994, 352, 393- 399.
4. 2B receptor in mouse gut, cardiovascular system, and brain. FEBS Lett., 1996, 391, 45-51.
5. 2B receptor-mediated serotonin morphogenetic functions in mouse cranial neural crest and myocardiac cells. Development, 1997, 124, 1745-1755.
6. Foguet M., Hoyer D., Pardo L. A., Parekh A., Kluxen F. W., Kalk- man H. O., Stühmer W. and Lübbert H., Cloning and functional characterization of the rat stomach fundus serotonin receptor. EM BO J. 1992, 11, 3481-3487.
7. Hoyer D., Hannon J. P. and Martin G. R., Molecular, pharmacological and functional diversity of 5-HT receptors. Pharmacol. Biochem. Behav., 2002, 71, 533-554.
8. Kursar J. D., Nelson D. L., Wainscott D. B., Cohen M. L. and Baez M., Molecular cloning, functional expression, and pharmacological characterisation of a novel serotonin (5-hydroxy- tryptamine2F) from rat stomach fundus. Mol. Pharmacol., 1992, 42, 549-557.
9. Lauder J. M., Neurotransmitters as morphogens. Prog. Brain Res., 1988, 73, 365-387.
10. Lauder J. M., Neurotransmitters as growth regulatory signals : role of receptors and second messensers. Trends Neurosci., 1993, 16, 233-240.
11. Lauder J. M., Wallace J. A. and Krebs H., Roles for serotonin in neuroembryogenesis. Adv. Exp. Med. Biol., 1981, 133, 477- 506.
12. Launay J.-M., Birraux G., Bondoux D., Callebert J., Choi D.-S., Loric S. and Maroteaux L., Ras involvement in signal transduction by the serotonin 5-HT,B receptor. J. Biol. Client., 1996, 271, 3141-3147.
13. 2B receptor in pulmonary hypertension. Nature Medecine, 2002, 8, 1129-1135.
14. 2-like receptor: Expression in brain, heart, and intestine. FEBSLett., 1992, 312, 203-207.
15. 2B receptor. J. Biol. Chem., 2000, 275, 9324-9331.
16. Mertens M. J. F., Pfaffendorf M. and Vanzwieten P. A., Cardiac effects of serotonin in hypertension. J. Hypertension, 1991, 9, S156-S157.
17. 2B receptor is required for heart development. Proc. Natl. Acad. Sci. USA, 2000a, 97, 950S-9513.
18. 2B-receptor signaling. FASEB J. 17, 1373-1375.
19. 2B receptors in mice leads to abnormal cardiac structure and function. Circulation, 2001, 103, 2973-2979.
20. 2B receptor in heart leads to abnormal mitochondrial function and cardiac hypertrophy. Circulation, 2003b, 107, 3223-3229.
21. 2B receptor regulates cell-cycle progression : Cross talk with tyrosine kinase pathways. Proc. Natl. Acad. Sci. USA, 2000b, 97, 2591-2596.
22. 2B receptor signaling in heart: Role of mitochondria in transition between hypertrophy and heart failure ? Circulation, 2003c, 108, 902-908.
23. Powell D. W., Mifflin R. C, Valentich J. D., Crowe S. E., Saada J. I. and West A. B., Myofibroblasts. I. Paracrine cells important in health and disease. Am. J. Physiol., 1999, 277, Cl- 9.
24. Schmuck K., Ullmer C, Engels P. and Lübbert H., Cloning and functional characterisation of the human 5-HT2B serotonin receptor. FEBS Lett., 1994, 342, 85-90.
25. Singh S., Johnson P. I., Javed A., Gray T. S., Lonchyna V. A. and Wurster R. D., Monoamine- and histamine-synthesizing enzymes and neurotransmitters within neurons of adult human cardiac ganglia. Circulation, 1999, 99, 411-419.
26. Tournois C, Mutel V., Manivet P., Launay J. M. and Keller- mann O., Cross-talk between 5-hydroxytryptamine receptors in a serotonergic cell line. Involvement of arachidonic acid metabolism. J. Biol. Client., 1998, 273, 17498-17503.
27. Ullmer C, Schmuck K., Kalkman H. O. and Lübbert H., Expression of serotonin receptor mRNA in blood vessels. FEBS Lett., 1995, 370, 215-221.
28. Villalon C. M., de Vries P. and Saxena P. R., Serotonin receptors as cardiovascular targets. Drug Discovery Today, 1997, 2, 294- 300.
29. Watts S. W., The development of enhanced arterial serotonergic hyperresponsiveness in mineralocorticoid hypertension. J. Hypertension, 1998, 16, 811-822.
30. 2B receptor and 5-HT receptor signal transduction in mesenteric arteries from deoxycorticosterone acetate- salt hypertensive rats. J. Pharmacol. Exp. Ther., 1996, 277, 1103-1113.
31. 2B-receptor antagonist LY- 272015 is antihypertensive in DOCA-salt- hypertensive rats. Am. J. Physiol., 1999, 276, H944-H952.
32. 2B receptor mediates contraction in the mesenteric artery of mineralocorticoid hypertensive rats. Hypertension, 1995, 26, 1056-1059.