Drosophila melanogaster GRD and LCCH3 subunits form heteromultimeric GABA-gated cation channels

British Journal of Pharmacology

Volumn 142, Issue 3, 2004, Pages 409-413

  Gisselmann, Günter ^a   Plonka, Justina ^a   Pusch, Hermann ^a   Hatt, Hanns ^a  

^a RUHR UNIVERSITY BOCHUM   (Germany)

Author keywords

Cation channel; Functional genomics; GABA receptor; Ligand gated ion channel; Xenopus laevis oocytes

Indexed keywords

4 AMINOBUTYRIC ACID; BICUCULLINE; CATION CHANNEL; DIAZEPAM; DIELDRIN; FLUNITRAZEPAM; GABA AND GLYCINE LIKE RECEPTOR OF DROSOPHILA; LIGAND GATED CHLORIDE CHANNEL HOMOLOG 3; LINDANE; MUSCIMOL; PICROTOXIN; PROTEIN SUBUNIT; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DROSOPHILA MELANOGASTER; IC 50; NONHUMAN; NUCLEOTIDE SEQUENCE; OOCYTE; PRIORITY JOURNAL; XENOPUS LAEVIS;

ANIMALS; CATIONS; CHLORIDE CHANNELS; CLONING, MOLECULAR; DROSOPHILA MELANOGASTER; GABA AGENTS; ION CHANNEL GATING; ION CHANNELS; MOLECULAR SEQUENCE DATA; OOCYTES; PROTEIN SUBUNITS; RECEPTORS, GABA; SEQUENCE ALIGNMENT; XENOPUS LAEVIS;

EID: 3042700208     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0705818     Document Type: Article

References (20)

1. BEG, A.A. & JORGENSEN, E.M. (2003). EXP-1 is an excitatory GABA-gated cation channel. Nat. Neurosci., 6, 1145-1152.
2. BORMANN, J. (2000). The 'ABC' of GABA receptors. Trends Pharmacol. Sci., 21, 16-19.
3. DUDEL, J. & HATT, H. (1976). Four types of GABA receptors in crayfish leg muscles characterized by desensitization and specific antagonist. Pflugers Arch., 364, 217-222.
4. FFRENCH-CONSTANT, R.H., MORTLOCK, D.P., SHAFFER, C.D., MACINTYRE, R.J. & ROUSH, R.T. (1991). Molecular cloning and transformation of cyclodiene resistance in Drosophila: an invertebrate gamma-aminobutyric acid subtype A receptor locus. Proc. Natl. Acad. Sci. U.S.A., 88, 7209-7213.
5. HARVEY, R.J., SCHMITT, B., HERMANS-BORGMEYER, I., GUNDELFINGER, E.D., BETZ, H. & DARLISON, M.G. (1994). Sequence of a Drosophila ligand-gated ion-channel polypeptide with an unusual amino-terminal extracellular domain. J. Neurochem., 62, 2480-2483.
6. HENDERSON, J.E., SODERLUND, D.M. & KNIPPLE, D.C. (1993). Characterization of a putative gamma-aminobutyric acid (GABA) receptor beta subunit gene from Drosophila melanogaster. Biochem. Biophys. Res. Commun., 193, 474-482.
7. HOSIE, A.M., ARONSTEIN, K., SATTELLE, D.B. & FFRENCH-CONSTANT, R.H. (1997). Molecular biology of insect neuronal GABA receptors. Trends Neurosci., 20, 578-583.
8. LEE, D., SU, H. & O'DOWD, D.K. (2003). GABA receptors containing RdI subunits mediate fast inhibitory synaptic transmission in Drosophila neurons. J. Neurosci., 23, 4625-4634.
9. LUDMERER, S.W., WARREN, V.A., WILLIAMS, B.S., ZHENG, Y., HUNT, D.C., AYER, M.B., WALLACE, M.A., CHAUDHARY, A.G., EGAN, M.A., MEINKE, P.T., DEAN, D.C., GARCIA, M.L., CULLY, D.F. & SMITH, M.M. (2002). Ivermectin and nodulisporic acid receptors in Drosophila melanogaster contain both gamma-aminobutyric acid-gated Rdl and glutamate-gated GluCl alpha chloride channel subunits. Biochemistry, 41, 6548-6560.
10. ORTELLS, M.O. & LUNT, G.G. (1995). Evolutionary history of the ligand-gated ion-channel superfamily of receptors. Trends Neurosci., 18, 121-127.
11. SATTELLE, D.B., PINNOCK, R.D., WAFFORD, K.A. & DAVID, J.A. (1988). GABA receptors on the cell-body membrane of an identified insect motor neuron. Proc. R. Soc. Lond. B, 232, 443-456.
12. STEIN, V. & NICOLL, R.A. (2003). GABA generates excitement. Neuron, 37, 375-378.
13. SWENSEN, A.M., GOLOWASCH, J., CHRISTIE, A.E., COLEMAN, M.J., NUSBAUM, M.P. & MARDER, E. (2000). GABA and responses to GABA in the stomatogastric ganglion of the crab Cancer borealis. J. Exp. Biol., 203 (Part 14), 2075-2092.
14. WITTE, I., KREIENKAMP, H.J., GEWECKE, M. & ROEDER, T. (2002). Putative histamine-gated chloride channel subunits of the insect visual system and thoracic ganglion. J. Neurochem., 83, 504-514.
15. WOTRING, V.E., MILLER, T.S. & WEISS, D.S. (2003). Mutations at the GABA receptor selectivity filter: a possible role for effective charges. J. Physiol., 548, 527-540.
16. ZHAINAZAROV, A.B., WACHOWIAK, M., BOETTCHER, A., ELENES, S. & ACHE, B.W. (1997). Ionotropic GABA receptor from lobster olfactory projection neurons. J. Neurophysiol., 77, 2235-2251.
17. ZHANG, H.G., FFRENCH-CONSTANT, R.H. & JACKSON, M.B. (1994). A unique amino acid of the Drosophila GABA receptor with influence on drug sensitivity by two mechanisms. J. Physiol., 479 (Part 1), 65-75.
18. ZHANG, H.G., LEE, H.J., ROCHELEAU, T., FFRENCH-CONSTANT, R.H. & JACKSON, M.B. (1995). Subunit composition determines picrotoxin and bicuculline sensitivity of Drosophila gamma-aminobutyric acid receptors. Mol. Pharmacol., 48, 835-840.
19. ZHANG, W., HAN, X.Y., WONG, S.M. & TAKEUCHI, H. (1997). Pharmacologic characteristics of excitatory gamma-aminobutyric acid (GABA) receptors in a snail neuron. Gen. Pharmacol., 28, 45-53.
20. ZUFALL, F., FRANKE, C. & HATT, H. (1989). Similarities between the effects of lindane (gamma-HCH) and picrotoxin on ligand-gated chloride channels in crayfish muscle membrane. Brain Res., 503, 342-345.