An insulin infusion protocol in critically ill cardiothoracic surgery patients

Annals of Pharmacotherapy

Volumn 38, Issue 7-8, 2004, Pages 1123-1129

  Zimmerman, Christopher R ^a   Mlynarek, Mark E ^a   Jordan, Jack A ^a   Rajda, Carol A ^a   Horst, H Mathilda ^a,b  

^a HENRY FORD HOSPITAL   (United States)

^b Surgical Intensive Care Unit

Author keywords

Infusion; Insulin; Intensive care

Indexed keywords

INSULIN;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; CRITICAL ILLNESS; DISEASE MARKER; FEMALE; GLUCOSE BLOOD LEVEL; HEART SURGERY; HUMAN; HYPERGLYCEMIA; HYPOGLYCEMIA; INSULIN INFUSION; INTENSIVE CARE; MAJOR CLINICAL STUDY; MALE; METABOLIC REGULATION; NURSE; POSTOPERATIVE CARE; POSTOPERATIVE INFECTION; PRIORITY JOURNAL; SURGICAL RISK; THORAX SURGERY;

BLOOD GLUCOSE; CARDIAC SURGICAL PROCEDURES; CLINICAL PROTOCOLS; COHORT STUDIES; CRITICAL ILLNESS; FEMALE; HUMANS; HYPOGLYCEMIC AGENTS; INFUSIONS, INTRAVENOUS; INSULIN; MALE; MIDDLE AGED; POSTOPERATIVE CARE;

EID: 3042694267     PISSN: 10600280     EISSN: None     Source Type: Journal    
DOI: 10.1345/aph.1E018     Document Type: Article

References (18)

1. L'Ecuyer PB, Murphy D, Little JR, Fraser VJ. The epidemiology of chest and leg wound infections following cardiothoracic surgery. Clin Infect Dis 1996;22:424-9.
2. Hill-Golden S, Peart-Vifilance C, Kao WHL, Brancati FL. Perioperative glycemic control and the risk of infectious complications in a cohort of adults with diabetes. Diabetes Care 1999;22:1408-14.
3. Spelman DW, Russo P, Harrington G, Davis BB, Rabinov M, Smith JA, et al. Risk factors for surgical wound infection and bacteraemia following coronary artery bypass surgery. Aust N Z J Surg 2000;70:47-51.
4. Nagachinta T, Stephens M, Reitz B, Polk BF. Risk factors for surgical-wound infection following cardiac surgery. J Infect Dis 1987;56:967-73.
5. Slaughter MS, Olson MM, Lee JT, Ward HB. A fifteen-year wound surveillance study after coronary artery bypass. Ann Thorac Surg 1993;56:1063-8.
6. McAlister FA, Man J, Bistritz L, Amad H, Tandon P. Diabetes and coronary artery bypass surgery. Diabetes Care 2003;26:1518-24.
7. Zerr KJ, Furnary AP, Grunkemeier GL, Bookin S, Kanhere V, Starr A. Glucose control lowers the risk of wound infection in diabetes after open heart operations. Ann Thorac Surg 1997;63:356-61.
8. Furnary AP, Zerr KJ, Grunkemeier GL, Starr A. Continuous intravenous insulin infusion reduces the incidence of deep sternal wound infection in diabetic patients after cardiac surgical procedures. Ann Thorac Surg 1999;67:352-62.
9. Furnary AP, Gao G, Grunkemeier GL, Wu YX, Zerr KJ, Bookin SO. Continuous insulin infusion reduces mortality in patients with diabetes undergoing coronary artery bypass grafting. J Thorac Cardiovasc Surg 2003;125:1007-18.
10. Rassias AJ, Marrin C, Arruda J, Whalen PK, Beach M, Yeager MP. Insulin infusion improves neutrophil function in diabetic cardiac surgery patients. Anesth Analg 1999;88:1011-6.
11. Gallacher SJ, Thomson G, Fraser WD, Fisher BM, Gemmell CG, MacCuish AC. Neutrophil bactericidal function in diabetes mellitus: evidence for association with blood glucose control. Diabet Med 1995;12:916-20.
12. Rassias AJ, Givan AL, Marrin CAS, Whalen K, Pahl J, Yeager MP. Insulin increases neutrophil count and phagocytic capacity after cardiac surgery. Anesth Analg 2002;94:1113-9.
13. McCowen KC, Malhotra A, Bistrian BR. Stress-induced hyperglycemia. Crit Care Clin 2001;17:107-23.
14. Qualis Health. Surgical Infection Collaborative Initiative Project page. www.qualishealth.org/collabs/sip/sip.htm (accessed 2003 May 1).
15. Brown G, Dodek P. Intravenous insulin nomogram improves blood glucose control in the critically ill. Crit Care Med 2001;29:1714-9.
16. van den Berghe G, Wouters P, Weekers F, Verwaest C, Bruyninckx F, Schetz M, et al. Intensive insulin therapy in critically ill patients. N Engl J Med 2001;345:1359-67.
17. van den Berghe G, Wouters PJ, Bouillon R, Weekers F, Verwaest C, Schetz M. Outcome benefit of intensive insulin therapy in the critically ill: insulin dose versus glycemic control. Crit Care Med 2003;31:359-66.
18. Malmberg K, Ryden L, Efendic S, Herlitz J, Nicol P, Waldstrom A, et al. Randomized trial of insulin-glucose infusion followed by subcutaneous insulin treatment in diabetic patients with acute myocardial infarction (DIGAMI study): effects on mortality at 1 year. J Am Coll Cardiol 1995;26:57-65.