NMR spectroscopic characterization of Metoprolol/cyclodextrin complexes in aqueous solution: Cavity size dependency

Journal of Pharmaceutical Sciences

Volumn 93, Issue 7, 2004, Pages 1659-1671

  Ikeda, Yoichi ^a   Hirayama, Fumitoshi ^b   Arima, Hidetoshi ^b   Uekama, Kaneto ^b   Yoshitake, Yasuyuki ^b   Harano, Kazunobu ^b  

^a WAKUNAGA PHARMACEUTICAL CO LTD   (Japan)

^b KUMAMOTO UNIVERSITY   (Japan)

Author keywords

Cavity size dependency; Cyclodextrins; Inclusion complexes; Metoprolol; Nuclear magnetic resonance spectroscopy; Stoichiometry

Indexed keywords

2 HYDROXYPROPYL BETA CYCLODEXTRIN; ALPHA CYCLODEXTRIN; BENZENE DERIVATIVE; BETA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; BETA CYCLODEXTRIN; CYCLODEXTRIN; GAMMA CYCLODEXTRIN; HYDROXYL GROUP; METHOXYETHYLBENZENE; METOPROLOL; UNCLASSIFIED DRUG;

AQUEOUS SOLUTION; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CHEMICAL INTERACTION; CIRCULAR DICHROISM; COMPLEX FORMATION; DRUG STRUCTURE; INCLUSION COMPLEX; MOLECULAR MODEL; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEAR OVERHAUSER EFFECT; PROTON NUCLEAR MAGNETIC RESONANCE; STOICHIOMETRY; ULTRAVIOLET SPECTROSCOPY;

EID: 3042688331     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/jps.20077     Document Type: Article

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