Is the Vpr R77Q mutation associated with long-term non-progression of HIV infection? [2]

AIDS

Volumn 18, Issue 9, 2004, Pages 1346-1347

  Fischer, Aurelie ^a   Lejczak, Cyrille ^a   Lambert, Christine ^a   Roman, François ^a   Servais, Jean ^b   Karita, Etienne ^b   Allen, Susan ^c   Schmit, Jean Claude ^a,d   Arendt, Victor ^a,d  

^a LUXEMBOURG INSTITUTE OF HEALTH   (Luxembourg)

^b Rwanda Treatment and Research Aids Center   (Rwanda)

^c UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^d CENTRE HOSPITALIER DE LUXEMBOURG   (Luxembourg)

Author keywords

[No Author keywords available]

Indexed keywords

VIRUS RNA; VPR PROTEIN;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; CARBOXY TERMINAL SEQUENCE; CLINICAL ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE COURSE; GENE DELETION; GENE MUTATION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LETTER; LYMPHOCYTE COUNT; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA TRANSCRIPTION; SEQUENCE ANALYSIS; VIRUS LOAD;

EID: 3042685364     PISSN: 02699370     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002030-200406180-00018     Document Type: Letter

References (4)

1. Lum JJ, Cohen OJ, Nie Z, Weaver JG, Gomez TS, Yao KJ, et al. Vpr R77Q is associated with long-term non-progressive HIV infection and impaired induction of apoptosis. J Clin Invest 2003, 111:1547-1554.
2. Wecker K, Morellet N, Bouaziz S, Roques BP. NMR structure of the HIV-1 regulatory protein Vpr in H2O/trifluoroethanol. Comparison with the Vpr N-terminal (1-51) and C-terminal (52-96) domains. AIDS Res Hum Retroviruses 2001, 17:911-923.
3. Bruns K, Fossen T, Wray V, Henklein P, Tessmer U, Schubert U. Structural characterization of the HIV-1 Vpr N-terminus: evidence of cis/trans proline isomerism. J Biol Chem 2003, 278:43188-43201.
4. Saksena NK, Ge YC, Wang B, Xiang SH, Dwyer DE, Randle C, et al. An HIV-1 infected long-term non-progressor (LTNP): molecular analysis of HIV-1 strains in the vpr and nef genes. Ann Acad Med Singapore 1996; 25:848-854.