Protein kinase C: A target for anticancer drugs?

Endocrine-Related Cancer

Volumn 11, Issue 2, 2004, Pages 161-162

  Maioli, E ^a   Fortino, V ^a  

^a UNIVERSITY OF SIENA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR;

CANCER; CANCER CELL; CARCINOGENESIS; CELL CYCLE; DRUG DESIGN; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; LETTER; MEDICAL LITERATURE; MEDICAL RESEARCH; PROTEIN EXPRESSION; PROTEIN FUNCTION; PUBLICATION;

ANIMALS; ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; ENZYME INHIBITORS; FEMALE; HUMANS; PROTEIN KINASE C;

EID: 3042682488     PISSN: 13510088     EISSN: None     Source Type: Journal    
DOI: 10.1677/erc.0.0110161     Document Type: Letter

References (8)

1. Barbacid M 1987 Ras genes. Annual Review of Biochemistry 56 779-827.
2. Corbit KC, Trakul N, Eves EM, Diaz B, Marshall M & Rosner MR 2003 Activation of Raf-1 signaling by protein kinase C through a mechanism involving Raf kinase inhibitory protein. Journal of Biological Chemistry 278 13061-13068.
3. Deng Q, Liao R & Sun P 2004 High intensity Ras signalling induces premature senescence by activating p38 pathway in primary human fibroblasts. Journal of Biological Chemistry 279 1050-1059.
4. Dumaz N & Marais R 2003 Protein kinase A blocks Raf-1 activity by stimulating 14-13-3 binding and blocking Raf-1 interaction with Ras. Journal of Biological Chemistry 32 29819-29823.
5. Kolch W, Heldecker G, Kochs G, Hummel R, Vahidi H, Mischak H, Finkenzeller G & Marmè D 1991 Protein kinase Cα activates RAF-1 by direct phosphorylation. Nature 364 249-252.
6. Mackay HJ & Twelves CJ 2003 Protein kinase C: a target for anticancer drugs? Endocrine-Related Cancer 10 389-396.
7. Shanmugan M, Krett NL, Maizels ET, Murad FM, Rosen ST & Hunzicker DM 2001 A role for protein kinase C delta in the differential sensitivity of MCF-7 and MDA-MB 231 human breast cancer cells to phorbol esters-induced growth arrest and p21 (WAF1/CIP1) induction. Cancer Letters 172 43-53.
8. Wu J, Dent P, Jelinek T, Wolfman A, Weber MJ & Sturgill TW 1993 Inhibition of the EGF-activated MAP kinase signalling pathway by adenosine 3′,5′-monophosphate. Science 262 1065-1069.