Mitochondria-targeting drug oligomycin blocked P-glycoprotein activity and triggered apoptosis in doxorubicin-resistant HepG2 cells

Chemotherapy

Volumn 50, Issue 2, 2004, Pages 55-62

  Li, Y C ^a   Fung, K P ^a   Kwok, T T ^a   Lee, C Y ^a   Suen, Y K ^a   Kong, S K ^a  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Apoptosis; Drug resistance; Mitochondria; Oligomycin; P glycoprotein

Indexed keywords

ANTINEOPLASTIC AGENT; CYTOCHROME C; DNA FRAGMENT; DOXORUBICIN; GLYCOPROTEIN P; OLIGOMYCIN;

APOPTOSIS; ARTICLE; CANCER CELL; CANCER CELL CULTURE; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG TARGETING; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME RELEASE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; PHARMACODYNAMICS; PRIORITY JOURNAL; PROTEIN EXPRESSION; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; CYTOCHROMES C; DNA FRAGMENTATION; DOXORUBICIN; DRUG DELIVERY SYSTEMS; DRUG INTERACTIONS; DRUG RESISTANCE, NEOPLASM; HUMANS; MITOCHONDRIA, LIVER; OLIGOMYCINS; P-GLYCOPROTEIN;

EID: 3042663289     PISSN: 00093157     EISSN: None     Source Type: Journal    
DOI: 10.1159/000077803     Document Type: Article

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