Poison hemlock (Conium maculatum L.)

Food and Chemical Toxicology

Volumn 42, Issue 9, 2004, Pages 1373-1382

  Vetter, J ^a  

^a SZENT ISTVÁN UNIVERSITY   (Hungary)

Author keywords

Animals; Conium maculatum; Hemlock; Human; Piperidine alkaloids; Poisoning

Indexed keywords

ACETIC ACID; CARBON; CONHYDRINE; CONIINE; GAMMA CONICEINE; N METHYLCONIINE; PIPERIDINE DERIVATIVE; PLANT TOXIN; PSEUDOCONHYDRINE; UNCLASSIFIED DRUG;

APIALES; BIRD; BOTANY; BRAIN DEPTH STIMULATION; CATTLE; COMA; CONIUM; CONVULSION; DEATH; DEPRESSION; ECONOMIC ASPECT; FLOWER; FRUIT; GOAT; HUMAN; HYPERVENTILATION; INSECT; INTOXICATION; MICTURITION; MOTOR DYSFUNCTION; MOTOR NERVE; NAUSEA; NERVOUS SYSTEM; NONHUMAN; PARALYSIS; PLANT; RABBIT; RED DEER; REVIEW; SALIVATION; SHEEP; SWINE; TOXICITY; TOXICOLOGY; TOXIN ANALYSIS; TOXIN STRUCTURE; VOMITING; WEED;

ANIMALIA; APIACEAE; AVES; BOS TAURUS; CAPRA HIRCUS; CERVUS ELAPHUS; CONIUM MACULATUM; EMBRYOPHYTA; HEXAPODA; ORYCTOLAGUS CUNICULUS; OVIS ARIES; SUS SCROFA;

EID: 3042654732     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2004.04.009     Document Type: Review

References (54)

1. Ahmed M., Ashraf M., Akbar G. Poisonous and injurious range plants in Pakistan. Progressive Farming. 9:1989;41-44
2. Baskin M., Baskin C. Seed germination ecology of poison hemlock, Conium maculatum. Canadian Journal of Botany. 68:1990;2018-2024
3. Berenbaum R., Harrison L. Agonopterix alstroemeriana (Oecophoridae) and other lepidopteran associates of poison hemlock (Conium maculatum) in east central Illinois. Great Lakes Entomologist. 27:1994;1-5
4. Biberci E., Altuntas Y., Cobanoglu A., Alpinar A. Acute respiratory arrest following hemlock (Conium maculatum) intoxication. Journal of Toxicology - Clinical Toxicology. 40:2002;517-518
5. Bowman C., Snaghvi S. Pharmacological actions of hemlock (Conium maculatum) alkaloids. Journal Pharmacoeutical Pharmacology. 15:1963;1-25
6. Cooper, R., Johnson, W., 1984. Poisonous plants in Britain and their effects on animals and man. Her Majesty's Stationery Office, London, p. 305
7. Copithorne B. Suspected poisoning of goats by hemlock (Conium maculatum). Veterinary Record. 49:1937;1018-1019
8. Corsi G., Biasci D. Secretory structures and localisation of alkaloids in Conium maculatum L. (Apiaceae). Annals of Botany. 81:1998;157-162
9. Cromwell J. The separation, microestimation and distribution of alkaloid of poison hemlock (Conium maculatum). Biochemical Journal. 64:1956;259-266
10. Drummer H., Roberts N., Bedford J., Crump L., Phelan H. Three deaths from hemlock poisoning. The Medical Journal of Australia. 162:1995;592-593
11. Fairbairn W., Challen B. The alkaloids of hemlock (Conium maculatum L.) distribution in relation to the development of the fruit. Biochemical Journal. 72:1959;556-561
12. Fairbairn W., Suwal N. The alkaloids of hemlock (Conium maculatum L.) II. Evidence for a rapid turnover of the major alkaloids. Phytochemistry. 1:1961;38-46
13. Forsyth S., Frank A. Evaluation of developmental toxicity of coniine to rats and rabbits. Teratology. 48:1993;59-64
14. Frank A., Reed M. Conium maculatum (poison hemlock) toxicosis in a flock of range turkeys. Avian Diseases. 31:1987;386-388
15. Frank A., Reed M. Comparative toxicity of coniine, an alkaloid of Conium maculatum (poison hemlock), in chickens, quails and turkeys. Avian Diseases. 34:1990;433-437
16. Frank S., Michelson B., Panter E., Gardner R. Ingestion of poison hemlock (Conium maculatum). West Journal of Medicine. 163:1995;573-574
17. Galey D., Holstege M., Fisher G. Toxicosis in dairy cattle exposed to poison hemlock (Conium maculatum) in hay: isolation of Conium alkaloids in plants, hay, and urine. Journal Veterinary Diagnostic Investigation. 4:1992;60-64
18. Hannam R. Hemlock (Conium maculatum) poisoning in the pig. Veterinary Record. 116:1985;322
19. Holm L. World Weeds, Natural Histories and Distribution. 1997;Wiley, New York. p. 1129
20. Howell E., Mink I. Viruses isolated from wild carrot and poison hemlock. Plant Diseases. 65:1981;277-279
21. James F., Nielsen B., Panter E. Impact of poisonous plants on the livestock industry. Journal of Range Management. 45:1992;3-8
22. Jessup A., Boermans J., Kock D. Toxicosis in tule elk caused by ingestion of poison hemlock. Journal American Veterinary Medicinal Association. 189:1986;1173-1175
23. Keeler F. Coniine, a teratogenic principle from Conium maculatum producing congenital malformations in calves. Clinical Toxicology. 7:1977;195-206
24. Keeler F., Balls D. Teratogenic effects in cattle of Conium maculatum and Conium alkaloids and analogues. Clinical Toxicology. 12:1978;49-64
25. Keeler F., Balls D., Shupe L., Crowe W. Teratogenicity and toxicity of coniine in cows, ewes and mares. Cornell Veterinary. 70:1980;19-26
26. Kielland J., Anders O. Conium maculatum in Hedmark county, Eastern Norway. Blyttia. 56:1998;92-93
27. Le Stragne R. A History of Herbal Plants. 1977;Angus and Robertson, London
28. Leete E., Olson O. Biosynthesis and metabolism of the hemlock alkaloids. Journal American Chemical Society. 94:1972;5472
29. Lopez A., Cid S., Bianchini L. Biochemistry of hemlock (Conium maculatum L.) alkaloids and their acute and chronic toxicity in livestock. A review. Toxicon. 37:1999;841-865
30. Mekkonen Y. A survey of plants (potentially) toxic to livestock in the Ethiopian flora. Ethiopian Journal of Science. 17:1994;9-32
31. Mitich W. Poison-hemlock (Conium maculatum L.). Weed Technology. 12:1998;194-197
32. Nielsen, B., James, F., 1985. Economic aspects of plant poisonings in livestock. In: Sawright, A.A., Hegarty, M.P., James, L.F., Keeler, R.F. (Eds.), Plant Toxicology, Proc. Austr. USA Poisonous Plants Symp., Brisbane. Queensland Poisonous Plants Com., Anim. Res. Inst. Yeerongpilly, pp. 23-31
33. Nitao J.K. Tests for toxicity of coniine to a polyphagous herbivore, Heliothis zea (Lepidoptera: Noctuidae). Environmental Entomology. 16:1987;656-663
34. Oztekin A. Les intoxications d'origine vegetale en Turquie (Plant poisoning cases in Turkey). Annales Pharmacologique France. 52:1994;260-265
35. Panter E., James F. Natural plant toxicants in milk: a review. Journal Animal Science. 68:1990;892-904
36. Panter E., Keeler F. Piperidine alkaloids of poison hemlock (Conium maculatum). Cheeke P.R. Toxicants of Plant Origin. Alkaloids. vol. 1:1989;109-132 CRC Press, Boca Raton, USA
37. Panter E., Keeler F., Buck B. Congenital skeletal malformations induced by maternal ingestion of Conium maculatum (poison hemlock) in newborn pigs. American Journal Veterinary Research. 46:1985;2064-2066
38. Panter E., Bunch D., Keeler F., Sisson V. Radio ultrasound observations of the fetotoxic effects in sheep from ingestion of Conium maculatum (poison hemlock). Clinical Toxicology. 26:1988;175-187
39. Panter E., Bunch D., Keeler F. Maternal and fetal toxicity of poison hemlock (Conium maculatum) in sheep. American Journal Veterinary Research. 49:1988;281-283
40. Panter E., Keeler F., Bunch D., Callan J. Congenital skeletal malformations and cleft palate induced in goats by ingestion of Lupinus, Conium and Nicotiana species. Toxicon. 28:1990;1377-1385
41. Panter E., Bunch D., Keeler F., Sisson V., Calan J. Multiple congenital contractures (MCC) and cleft palate induced in goats by ingestion of piperidine alkaloid containing plants: reduction of fetal movement as the probable cause. Clinical Toxicology. 28:1990;69-83
42. Panter E., James F., Gardner R., Ralphs H., Pfister J., Stegelmeier L., Lee T. Reproductive losses to poisonous plants: influence of management strategies. Journal of Range Management. 55:2002;301-308
43. Parsons T. Noxious Weeds of Victoria. 1973;Inkata Press, Melbourne, Australia
44. Penny H. Hemlock poisoning in cattle. Veterinary Record. 42:1953;669-670
45. Rizzi D., Basile C., Di Maggio A. Rhabdomyolysis and acute tubular necrosis in coniine hemlock poisoning. Lancet. 2:1989;1461-1462
46. Rizzi D., Basile C., Di-Maggio A., Sebastio A., Introna F. Jr., Scatizzi A., De-Marco S., Smialek E. Clinical spectrum of accidental hemlock poisoning: neurotoxic manifestations, rhabdomyolysis and acute tubular necrosis. Nephrological Dialysis Transplantation. 6:1991;939-943
47. Roberts F., Brown T. A new alkaloid from South African Conium species. Phytochemistry. 20:1981;447
48. Scatizzi A., Di-Maggio A., Rizzi D., Sebastio M., Basile C. Acute renal failure due to tubular necrosis caused by wildfowl-mediated hemlock poisoning. Renal Failure. 15:1993;93-96
49. Scutchfield D., Genovese N. Terrible death of Socrates: some medical and classical reflections. Pharos. 60:1997;30-33
50. Short B., Edwards C. Accidental Conium maculatum poisoning in the rabbit. Veterinary Human Toxicology. 31:1989;54-57
51. Simpson A., Weiner C. The Oxford English Dictionary, vol. 7. second ed. 1989;Clarendon Press, Oxford
52. Vetter J. Poisonous plants - plant poisonings I. Gyógyszeré szet. 43:1999;80-96
53. Widmer R. Poison hemlock toxicosis in swine. Veterinary Medicine. 79:1984;405-408
54. Zdanevich V., Belodubrovskaya A. Conium maculatum: chemical composition, useful and harmful properties. Rastitelnye Resursy. 33:1997;108-113