An unusual cleavage reaction of a peptide observed during dithiotreitol and tris(2-carboxyethyl)phosphine reduction: Application to sequencing of HpTx2 spider toxin using nanospray tandem mass spectrometry

Rapid Communications in Mass Spectrometry

Volumn 18, Issue 12, 2004, Pages 1317-1323

  Legros, Christian ^a   Célérier, Marie Louise ^b   Guette, Catherine ^c  

^a UNIVERSITÉ D EVRY VAL D ESSONNE   (France)

^b CNRS   (France)

^c MUSÉUM NATIONAL D'HISTOIRE NATURELLE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

COVALENT BONDS; MASS SPECTROMETRY; PHOSPHORUS COMPOUNDS; SULFUR COMPOUNDS; TOXIC MATERIALS;

% REDUCTIONS; CLEAVAGE REACTION; CLOSE PROXIMITY; LOW-ENERGY COLLISION-INDUCED DISSOCIATION; NANOELECTROSPRAY; NANOSPRAY; SPIDER TOXINS; TANDEM MASS SPECTROMETRY; TANDEM-MASS SPECTROMETRY; TRIS(2 CARBOXYETHYL)PHOSPHINE;

PEPTIDES;

CYSTINE; DITHIOTHREITOL; ION; PEPTIDE; PHOSPHINE DERIVATIVE; RECOMBINANT PROTEIN; SPIDER VENOM; SPIDER VENOM HPTX2; TRIS(2 CARBOXYETHYL)PHOSPHINE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CHEMICAL REACTION; CLEAVAGE REACTION; COLLISIONALLY ACTIVATED DISSOCIATION; DISULFIDE BOND; HYDROLYSIS; NONHUMAN; REDUCTION; TANDEM MASS SPECTROMETRY; TOXIN ANALYSIS; TOXIN STRUCTURE;

EID: 3042643227     PISSN: 09514198     EISSN: None     Source Type: Journal    
DOI: 10.1002/rcm.1490     Document Type: Article

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