Warfarin-intractable, intraatrial thrombogenesis in a 52-year-old woman with mitral stenosis and chronic atrial fibrillation

Tohoku Journal of Experimental Medicine

Volumn 203, Issue 1, 2004, Pages 59-63

  Fukuchi, Mitsumasa ^a   Kumagai, Koji ^a   Sakuma, Masahito ^a   Kagaya, Yutaka ^a   Watanabe, Jun ^a   Tabayashi, Koichi ^a   Shirato, Kunio ^a  

^a TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Atrial fibrillation; Fibrin; Immunohistochemistry; Platelet; Thrombosis

Indexed keywords

ANTITHROMBOCYTIC AGENT; DIGOXIN; DIURETIC AGENT; FIBRINOGEN RECEPTOR; VON WILLEBRAND FACTOR; WARFARIN;

ADULT; ARTICLE; BRAIN INFARCTION; CASE REPORT; CHRONIC DISEASE; ENDOCARDIUM; FEMALE; FIBRIN CLOT; HEART ATRIUM FIBRILLATION; HEART ATRIUM THROMBOSIS; HUMAN; IMMUNOHISTOCHEMISTRY; MITRAL VALVE REPLACEMENT; MITRAL VALVE STENOSIS; NEOVASCULARIZATION (PATHOLOGY); THROMBECTOMY; THROMBOCYTE AGGREGATION; TRANSESOPHAGEAL ECHOCARDIOGRAPHY;

ADULT; ATRIAL FIBRILLATION; CORONARY THROMBOSIS; DRUG RESISTANCE; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MIDDLE AGED; MITRAL VALVE STENOSIS; PLATELET AGGREGATION; THROMBECTOMY; WARFARIN;

EID: 3042638015     PISSN: 00408727     EISSN: None     Source Type: Journal    
DOI: 10.1620/tjem.203.59     Document Type: Article

References (9)

1. Abe, Y., Asakura, T., Sakamoto, N., Ishikawa, S., Muroi, S., Saitoh, F., Satoh, M., Suzuki, S., Ono, M., Sakabe, A., Iwai, M., Sando, M., Gotou, J., Watanabe, Y., Nagata, K., Maehara, K. & Maruyama, Y. (2003) Embolic attack in patients with atrial fibrillation and atrial thrombus depends on the character of the thrombus. Circ. J., 67, 203-208.
2. Atrial Fibrillation Investigators (1994) Risk factors for stroke and efficacy of antithrombotic therapy in atrial fibrillation. Analysis of pooled data from five randomized controlled trials. Arch. Intern. Med., 154, 1449-1457.
3. Fukuchi, M., Watanabe, J., Kumagai, K., Katori, Y., Baba, S., Fukuda, K., Yagi, T., Iguchi, A., Yokoyama, H., Miura, M., Kagaya, Y., Sato, S., Tabayashi, K. & Shirato, K. (2001) Increased von Willebrand factor in the endocardium as a local predisposing factor for thrombogenesis in overloaded human atrial appendage. J. Am. Coll. Cardiol., 37, 1436-1442.
4. Gonzalez-Torrecilla, E., Garcia-Fernandez, M.A., Perez-David, E., Bermejo, J., Moreno, M. & Delcan, J.L. (2000) Predictors of left atrial spontaneous echo contrast and thrombi in patients with mitral stenosis and atrial fibrillation. Am. J. Cardiol., 86, 529-534.
5. Lip, G.Y.H., Lip, P.L., Zarifis, J., Watson, R.D.S., Bareford, D., Lowe, G.D.O. & Beevers, D.G. (1996) Fibrin D-dimer and β-thromboglobulin as markers of thrombogenesis and platelet activation in atrial fibrillation. Effects of introducing ultra-low-dose warfarin and aspirin. Circulation, 94, 425-431.
6. Matsui, H., Sugimoto, M., Mizuno, T., Tsuji. S., Miyata, S., Matsuda, M. & Yoshioka, A. (2002) Distinct and concerted functions of von Willebrand factor and fibrinogen in mural thrombus growth under high shear flow. Blood, 100, 3604-3610.
7. Narumiya, T., Sakamaki, T., Sato, Y. & Kanmatsuse, K. (2003) Relationship between left atrial appendage function and left atrial thrombus in patients with nonvalvular chronic atrial fibrillation and atrial flutter. Circ. J., 67, 68-72.
8. Prystowsky, E.N., Benson, D.W., Jr., Fuster, V., Hart, R.G., Kay, G.N., Myerburg, R.J., Naccarelli, G.V. & Wyse, D.G. (1996) Management of patients with atrial fibrillation. A statement for Healthcare Professionals from the Subcommittee on electrocardiography and electrophysiology, American Heart Association. Circulation, 93, 1262-1277.
9. Stoddard, M.F., Dawkins, P.R., Prince, C.R. & Ammash, N.M. (1995) Left atrial appendage thrombus is not uncommon in patients with acute atrial fibrillation and a recent embolic event: a transesophageal echocardiographic study. J. Am. Coll. Cardiol., 25, 452-459.